116041-30-6

Basic information

• Product Name: (R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE
• Synonyms: (R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE;1-benzyl-5-(hydroxymethyl)pyrrolidin-2-one
• CAS NO: 116041-30-6
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.25
• Mol File: 116041-30-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE(116041-30-6)
• EPA Substance Registry System: (R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE(116041-30-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 116041-30-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-Benzyl-5-hydroxymethyl-2-pyrrolidinone is used as a chiral building block for the synthesis of biologically active molecules, such as pharmaceutical drugs and agrochemicals. Its unique structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Chemical Industry:
(R)-1-Benzyl-5-hydroxymethyl-2-pyrrolidinone serves as a ligand in asymmetric catalytic reactions, which are crucial for the production of enantiomerically pure compounds. This application is significant in the synthesis of various chemicals and materials with specific properties and functions.
Used in Research and Development:
Due to its potential pharmaceutical applications and versatility, (R)-1-Benzyl-5-hydroxymethyl-2-pyrrolidinone is utilized in research and development for exploring new methods of synthesis, understanding its interactions with other molecules, and identifying novel applications in various industries.

Upstream product

• 330173-08-5 N-benzyl-2-(4-methylphenylsulfonyl)acetamide 
• 103301-78-6 1-benzyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 4931-66-2 methyl 5-oxopyrrolidine-2-carboxylate 
• 100-39-0 benzyl bromide 

Downstream Products

• 67131-44-6 1-benzyl-2-(hydroxymethyl)pyrrolidine 
• 116041-31-7 1-benzyl-5-hydroxymethyl-pyrrolidin-2-one methanesulphonic acid ester 

Relevant articles and documents

Rhodium-Catalyzed Stereospecific C?H Amination for the Construction of Spiroaminal Cores: Reactivity Difference between Nitrenoid and Carbenoid Species against Amide Functionality

Metal nitrenoids and metal carbenoids exhibit similar reactivity for insertion into a C?H bond and a C=C double bond. These reactions have attracted the attention of organic chemists due to their unusual bond-forming ability, but the reactivity difference between these chemical species has not been studied. In this paper, we examined the reactivity difference using the corresponding Rh nitrenoid and Rh carbenoid precursors. The Rh nitrenoid inserted into an intramolecular C(sp3)?H bond adjacent to an amide nitrogen, affording functionalized spiroaminals that are ubiquitous in natural products, while the Rh carbenoid inserted into an amide C?N bond. The totally different reactivity was rationalized by the relatively low energy barrier for the C?H insertion reaction of the Rh nitrenoid. Computational analysis suggests that the origin of the discrepancy is the electrophilicity of the coordinating atoms to the Rh complex.

New synthesis and application of 3-substituted prolinols

Carbon skeleton of polysubstituted pyroglutamates with three contiguous asymmetric centers was built up in one base-induced coupling/cyclization reaction of α-sulfonylacetamide with 2-bromo-2-propenoates. A simple transformation to 3-substituted prolinols

3-arylcarbonyl-1-(C-attached-N-heteryl)-1H-indoles

2-R2 -R4 -substituted-3-R3 -CO-1-[(C-attached-N-herteryl)-(Alk)n ]-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.

5-Substituted 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinones, pharmaceutical compositions and use

There are disclosed compounds of the formula STR1 where R1 is loweralkoxycarbonyl, --CH2 OH or --CONR3 R4, R3 and R4 being independently hydrogen, loweralkyl or arylloweralkyl; and R2