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METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE, a chemical compound with the molecular formula C10H9NO3, is a derivative of indole. It features a hydroxy group at the 6th carbon atom of the indole ring and a methyl ester group attached to the carboxylic acid. METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE is recognized for its potential biological activities, including anti-inflammatory, anticancer, and antimicrobial properties, and is also valued in organic chemistry for the synthesis of heterocyclic compounds.

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  • 116350-38-0 Structure
  • Basic information

    1. Product Name: METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE
    2. Synonyms: METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE;6-Hydroxy-1H-indole-2-carboxylic acid methyl ester
    3. CAS NO:116350-38-0
    4. Molecular Formula: C10H9NO3
    5. Molecular Weight: 191.18
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 116350-38-0.mol
  • Chemical Properties

    1. Melting Point: 171-172 °C
    2. Boiling Point: 405.6±25.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.383±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 9.33±0.40(Predicted)
    10. CAS DataBase Reference: METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE(116350-38-0)
    12. EPA Substance Registry System: METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE(116350-38-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 116350-38-0(Hazardous Substances Data)

116350-38-0 Usage

Uses

Used in Pharmaceutical Industry:
METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE is used as an intermediate in the synthesis of pharmaceutical drugs due to its potential biological activities, which include anti-inflammatory, anticancer, and antimicrobial properties. Its presence in the synthesis process aids in the development of new medications that can address various health conditions.
Used in Agrochemical Industry:
In the agrochemical industry, METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE is used as an intermediate in the synthesis of agrochemicals. Its role is crucial in creating compounds that can protect crops from pests and diseases, thereby ensuring agricultural productivity.
Used in Organic Chemistry:
METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE is used as a building block in the synthesis of various heterocyclic compounds within the field of organic chemistry. Its unique structure allows for the creation of complex molecules that can have a range of applications, from pharmaceuticals to specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 116350-38-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,3,5 and 0 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 116350-38:
(8*1)+(7*1)+(6*6)+(5*3)+(4*5)+(3*0)+(2*3)+(1*8)=100
100 % 10 = 0
So 116350-38-0 is a valid CAS Registry Number.

116350-38-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE

1.2 Other means of identification

Product number -
Other names methyl 6-hydroxyindole-2-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:116350-38-0 SDS

116350-38-0Relevant articles and documents

Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists

Gim, Hyo Jin,Cheon, Ye-Jin,Ryu, Jae-Ha,Jeon, Raok

supporting information; experimental part, p. 3057 - 3061 (2011/06/26)

A series of benzoxazole or benzothiazole containing indole analogs, 6-alkoxyindole-2-carboxylic acids and 5-alkoxy-3-indolylacetic acids, were synthesized as novel candidates of PPARγ/δ dual agonists and their ligand activities for PPAR subtypes (α, γ, an

FARNESOID X RECEPTOR AGONISTS

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Page/Page column 77, (2009/01/23)

The present invention relates to famesoid X receptors (FXR, NR1 H4) FXR is a member of the nuclear receptor class of ligand-activated transcription factors More particularly, the present invention relates to compounds useful as agonists for FXR, pharmaceu

CHEMICAL COMPOUNDS

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Page/Page column 165, (2009/01/24)

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

Substituted Indoles, Compositions Containing Them, Method for the Production Thereof and Their Use

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Page/Page column 21, (2008/06/13)

Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal products, in particular as antican

ANTIFUNGAL AGENT CONTAINING PYRIDINE DERIVATIVE

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Page/Page column 51, (2008/06/13)

The present invention provides an antifungal agent that has superior antifungal action and is also superior in terms of physical properties, safety and metabolic stability. The present invention discloses a compound represented by the formula (I): (wherein X represents an oxygen atom, a sulfur atom or -NH-, R1 represents a hydrogen atom, a halogen atom, a cyano group, an amino group or a substituent, and R2 and R3 independently represent a hydrogen atom, a halogen atom, a hydroxyl group or a substituent, except for a case in which R2 and R3 are both hydrogen atoms), and an antifungal agent containing the above compound.

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