1172068-36-8

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridin-3-aMine, 5-broMo-4-fluoro-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridin-3-aMine, 5-broMo-4-fluoro-;5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine;5-Bromo-4-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-3-Amine(WX637191)
• CAS NO: 1172068-36-8
• Molecular Formula: C₇H₅BrFN₃
• Molecular Weight: 230.0371032
• Mol File: 1172068-36-8.mol

Chemical Properties

• Boiling Point: 213.6±40.0 °C(Predicted)
• Appearance: /
• Density: 2.09±0.1 g/cm3(Predicted)
• PKA: 4.90±0.20(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridin-3-aMine, 5-broMo-4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridin-3-aMine, 5-broMo-4-fluoro-(1172068-36-8)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridin-3-aMine, 5-broMo-4-fluoro-(1172068-36-8)

Safety Data

• Hazardous Substances Data: 1172068-36-8(Hazardous Substances Data)

Upstream product

• 1172067-95-6 5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridine 
• 640735-25-7 4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine 
• 640735-24-6 4-bromo-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine 
• 348640-06-2 4-bromo-7-azaindole 
• 1172068-33-5 5-bromo-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1196508-42-5 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide trifluoroacetate 
• 1196505-03-9 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide hydrochloride 
• 1196504-51-4 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride 
• 1196504-67-2 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride 
• 1196504-40-1 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methylbenzamide hydrochloride 
• 1196504-96-7 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclobutanecarboxamide hydrochloride 
• 1196508-97-0 (R)-tert-butyl 1-(5-bromo-3-(3-chloro-4-fluorobenzamido)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-ylcarbamate 
• 1196508-54-9 (R)-tert-butyl 1-(5-bromo-3-(3-fluorobenzamido)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-ylcarbamate 
• 1196508-39-0 (R)-tert-butyl 1-(5-bromo-3-(3-methoxybenzamido)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-ylcarbamate 
• 1196507-83-1 (R)-tert-butyl 1-(5-bromo-3-(3-methylbenzamido)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-ylcarbamate 
• 1196508-29-8 N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidine-2-carboxamide 
• 1196508-52-7 N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-fluorobenzamide 
• 1196509-30-4 N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)acetamide 
• 1196507-80-8 N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methylbenzamide 

Relevant articles and documents

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof: (I) The terms Z, Y, and R1 are as defined in the claims.

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof : (I) The terms Z, Y, and R1 are as defined in the claims.

PYRROLOPYRIDINES AS KINASE INHIBITORS

Compounds of Formula (I) are useful for inhibition of CHKl and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

PYRROLOPYRIDINES AS KINASE INHIBITORS

Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.Formula, (I).