117966-22-0

Usage

Chemical Class

The compound belongs to the indole class of compounds.

Derivative

It is a derivative of 1H-indole.

Substituents

The compound contains an acetyl group and a phenylsulfonyl group.

Usage

It is often used in organic synthesis as a reagent or intermediate.

Reactivity

The phenylsulfonyl group can act as a leaving group in nucleophilic substitution reactions, while the indole ring can participate in aromatic substitution reactions.

Versatility

1H-Indole, 2-acetyl-1-(phenylsulfonyl)is a versatile and useful compound for the synthesis of various organic molecules.

Upstream product

• 80360-24-3 1<1-(phenylsulfonyl)indol-2-yl>ethanol 
• 40899-71-6 1-benzenesulfonylindole 
• 108-24-7 acetic anhydride 
• 120-72-9 indole 
• 98-09-9 benzenesulfonyl chloride 
• 5344-90-1 2-Aminobenzyl alcohol 
• 151721-32-3 N-benzenesulfonyl-o-aminobenzaldehyde 
• 197847-57-7 N-[2-(hydroxymethyl)phenyl]benzenesulfonamide 

Downstream Products

• 117966-24-2 5-(1-(phenylsulfonyl)indol-2-yl)-3-thiomethyl-1,2,4-triazine 
• 117966-25-3 1-Benzenesulfonyl-2-(3-methanesulfonyl-[1,2,4]triazin-5-yl)-1H-indole 
• 117966-23-1 2-(1-(phenylsulfonyl)indol-2-yl)-2-oxoethanal 
• 127680-63-1 1-Benzenesulfonyl-2-ethyl-2,3-dihydro-1H-indole 
• 68051-21-8 2-ethyl-1-(phenylsulfonyl)-1H-indole 

Relevant academic research and scientific papers

N-SULFONYL INDOLE DERIVATIVE COMPOUND AND USE THEREOF

PROBLEM TO BE SOLVED: To provide an N-sulfonyl indole derivative compound useful for the treatment of cancer and hypertension. SOLUTION: This invention provides an N-sulfonyl indole derivative compound represented by formula (1) where R1 is an aryl group, cycloalkyl group or heteroaryl group, and R2 is Si(R5)(R6)(R7), C1-C6 alkyl group or acetyl group. COPYRIGHT: (C)2016,JPOandINPIT

One-pot synthesis of 1-phenylsulfonyl-2-aroylindoles

Interaction of phenylsulfonyl-2-aminobenzaldehyde with 2-bromo-1- phenylethanones in the presence of K2CO3 followed by acid-catalyzed dehydration led to the formation of 1-phenylsulfonyl-2-aroylindoles.Copyright Taylor & Francis Group, LLC.

Heterocycles from ylides. Part X.Synthesis of 3-hydroxy-2,3-dihydroindoles by a domino reaction

A domino reaction between 2-N-phenylsulfonylaminobenzaldehyde (1) and sulfonium ylides (2) leads to 3-hydroxy-2,3-dihydroindoles (3) whose structure was confirmed on the basis of analytical and spectroscopic data.

A direct lithiation route to 2-acyl-1-(phenylsulfonyl)indoles

2-Acyl-1-(phenylsulfonyl)indoles (3, 7-9) are prepared in 75-84% yield from 1-(phenylsulfonyl)indoles (1, 5) in one operation by treatment of the latter with s-butyllithium followed by inverse quenching of the C-2 lithioindoles with carboxylic acid anhydr

Reaction of indole-2,3-dicarboxylic anhydride with grignard reagents: synthesis of 2-acylindoles

Reaction of indole-2,3-dicarboxylic anhydride with methylmagnesium bromide and phenylmagnesium bromide gave 2-acetyl- and 2-benzoyl-indole-3-carboxylic acids, but with tert-butylmagnesium chloride, 3-pivaloylindole-2-carboxylic acids were obtained as the main products. Treatment of 2-acylindole-3-carboxylic acids with copper chromite in quinoline or potassium hydroxide gave the corresponding 2-acylindoles.

Synthesis of Alkyl-Substituted N-Protected Indoles via Acylation and Reductive Deoxygenation

The synthesis of 2-, 3-, and 5-alkyl-1-(phenylsulfonyl)indoles involving Friedel-Crafts acylation followed by reductive deoxygenation is described.The application of this acylation-deoxygenation sequence to 3-acyl-1-(phenylsulfonyl)indoles bearing potenti

A DIRECTED METALATION ROUTE TO THE ZWITTERIONIC INDOLE ALKALOIDS. SYNTHESIS OF SEMPERVIRINE

A synthesis protocol involving beta-lithiation of 2-(2-pyridinyl)indoles(45) and subsequent reaction with bromoacetaldehyde leads to the indoloquinolizine (1) ring system.Application of this methodology to 2-(2-pyridinyl)indole 17, which is prepared via Taylor-Boger triazine Diels-Alder annulation chemistry, affords the zwitterionic indole alkaloid sempervirine (3).