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6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole is a complex chemical compound with a unique structure, featuring a bromine atom, a fluorine atom within a nitrophenyl group, and a methyl group attached to an indazole framework, which is a fused benzene and pyrazole ring system. 6-broMo-5-(2-fluoro-4-nitrophenoxy)-1-Methyl-1H-indazole is relatively rare and specialized, with its potential applications being contingent upon the reactivity and interactions of its various functional groups.

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  • 1206800-24-9 Structure
  • Basic information

    1. Product Name: 6-broMo-5-(2-fluoro-4-nitrophenoxy)-1-Methyl-1H-indazole
    2. Synonyms: 6-broMo-5-(2-fluoro-4-nitrophenoxy)-1-Methyl-1H-indazole;1H-Indazole, 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-
    3. CAS NO:1206800-24-9
    4. Molecular Formula: C14H9BrFN3O3
    5. Molecular Weight: 366.1419632
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1206800-24-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 435.0±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.70±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: -0.31±0.30(Predicted)
    10. CAS DataBase Reference: 6-broMo-5-(2-fluoro-4-nitrophenoxy)-1-Methyl-1H-indazole(CAS DataBase Reference)
    11. NIST Chemistry Reference: 6-broMo-5-(2-fluoro-4-nitrophenoxy)-1-Methyl-1H-indazole(1206800-24-9)
    12. EPA Substance Registry System: 6-broMo-5-(2-fluoro-4-nitrophenoxy)-1-Methyl-1H-indazole(1206800-24-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1206800-24-9(Hazardous Substances Data)

1206800-24-9 Usage

Uses

Used in Pharmaceutical Synthesis:
6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole is used as a reactant in the synthesis of more complex molecules, particularly for the development of pharmaceuticals and bioactive compounds. Its diverse functional groups and reactive moieties make it a promising candidate for creating new drug molecules with potential therapeutic applications.
Used in Bioactive Compound Production:
In the field of biochemistry, 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole is used as a building block for the production of bioactive compounds. Its structural complexity and the presence of multiple functional groups allow for the creation of molecules with specific biological activities, which could be utilized in research and development of new therapeutic agents.
Note: The specific applications and uses mentioned above are hypothetical and based on the potential reactivity of the compound's functional groups. More detailed information and research would be required to confirm the exact applications and benefits of 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole in these fields.

Check Digit Verification of cas no

The CAS Registry Mumber 1206800-24-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,6,8,0 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1206800-24:
(9*1)+(8*2)+(7*0)+(6*6)+(5*8)+(4*0)+(3*0)+(2*2)+(1*4)=109
109 % 10 = 9
So 1206800-24-9 is a valid CAS Registry Number.
InChI:InChI=1S/C14H9BrFN3O3/c1-18-12-6-10(15)14(4-8(12)7-17-18)22-13-3-2-9(19(20)21)5-11(13)16/h2-7H,1H3

1206800-24-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methylindazole

1.2 Other means of identification

Product number -
Other names 6-Bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1206800-24-9 SDS

1206800-24-9Relevant articles and documents

An Alternative Indazole Synthesis for Merestinib

Lu, Yu,Cole, Kevin P.,Fennell, Jared W.,Maloney, Todd D.,Mitchell, David,Subbiah, Ramesh,Ramadas, Balakumar

, p. 409 - 419 (2018)

A new synthesis of a key indazole-containing building block for the MET kinase inhibitor merestinib was designed and demonstrated. Crucial to the successful construction of the challenging indazole is an SNAr reaction, which forges the heterocy

TRK INHIBITOR AS ANTI-CANCER DRUG

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Paragraph 0182; 0183, (2021/07/17)

The present disclosure relates to a group of tropomyosin receptor kinase inhibitors comprising an amido-phenoxy-indazole structure fragment. These compounds show potent inhibitory effects on various oncogenic kinases, especially TRK, and thus can be used

Route design and development of a MET kinase inhibitor: A copper-catalyzed preparation of an N 1 - Methylindazole

Kallman, Neil J.,Liu, Chin,Yates, Matthew H.,Linder, Ryan J.,Ruble, J. Craig,Kogut, Eugene F.,Patterson, Lawrence E.,Laird, Dana L. T.,Hansen, Marvin M.

, p. 501 - 510 (2014/05/06)

The synthesis of a MET kinase inhibitor in an overall yield of 22% was achieved over eight steps starting with 3-hydroxybenzaldehyde, an improvement from the initial 12-step process with a 5.4% yield. Highlights of the process chemistry design and development are a Cu-catalyzed cyclization to form an important N1-methylindazole ring, a selective nitro reduction in the presence of an aryl bromide, a late-stage Suzuki cross-coupling, and a base-promoted Boc deprotection to form the desired drug candidate.

AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET

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Page/Page column 5, (2010/02/17)

The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer.

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