1206800-24-9Relevant articles and documents
An Alternative Indazole Synthesis for Merestinib
Lu, Yu,Cole, Kevin P.,Fennell, Jared W.,Maloney, Todd D.,Mitchell, David,Subbiah, Ramesh,Ramadas, Balakumar
, p. 409 - 419 (2018)
A new synthesis of a key indazole-containing building block for the MET kinase inhibitor merestinib was designed and demonstrated. Crucial to the successful construction of the challenging indazole is an SNAr reaction, which forges the heterocy
TRK INHIBITOR AS ANTI-CANCER DRUG
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Paragraph 0182; 0183, (2021/07/17)
The present disclosure relates to a group of tropomyosin receptor kinase inhibitors comprising an amido-phenoxy-indazole structure fragment. These compounds show potent inhibitory effects on various oncogenic kinases, especially TRK, and thus can be used
Route design and development of a MET kinase inhibitor: A copper-catalyzed preparation of an N 1 - Methylindazole
Kallman, Neil J.,Liu, Chin,Yates, Matthew H.,Linder, Ryan J.,Ruble, J. Craig,Kogut, Eugene F.,Patterson, Lawrence E.,Laird, Dana L. T.,Hansen, Marvin M.
, p. 501 - 510 (2014/05/06)
The synthesis of a MET kinase inhibitor in an overall yield of 22% was achieved over eight steps starting with 3-hydroxybenzaldehyde, an improvement from the initial 12-step process with a 5.4% yield. Highlights of the process chemistry design and development are a Cu-catalyzed cyclization to form an important N1-methylindazole ring, a selective nitro reduction in the presence of an aryl bromide, a late-stage Suzuki cross-coupling, and a base-promoted Boc deprotection to form the desired drug candidate.
AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET
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Page/Page column 5, (2010/02/17)
The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer.