1213-33-8

Basic information

• Product Name: 2-[(4-methylphenyl)sulfonyl]aniline
• CAS NO: 1213-33-8
• Molecular Formula: C₁₃H₁₃NO₂S
• Molecular Weight: 247.3128
• Mol File: 1213-33-8.mol

Chemical Properties

• Boiling Point: 445°C at 760 mmHg
• Flash Point: 222.9°C
• Density: 1.259g/cm³
• Vapor Pressure: 4.1E-08mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 2-[(4-methylphenyl)sulfonyl]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-methylphenyl)sulfonyl]aniline(1213-33-8)
• EPA Substance Registry System: 2-[(4-methylphenyl)sulfonyl]aniline(1213-33-8)

Safety Data

• Hazardous Substances Data: 1213-33-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-[(4-methylphenyl)sulfonyl]aniline is utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of biologically active molecules. Its presence in the molecular structure can influence the pharmacological properties of the resulting compounds, making it an essential component in drug development.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 2-[(4-methylphenyl)sulfonyl]aniline serves as a versatile intermediate for the creation of a wide array of organic compounds. Its sulfonyl and aniline functionalities provide a foundation for various chemical reactions, facilitating the production of complex organic molecules.
Used in Dye and Pigment Production:
2-[(4-methylphenyl)sulfonyl]aniline is employed as an intermediate in the production of dyes and pigments due to its capacity to form colored compounds. Its chemical structure allows for the development of dyes with specific color characteristics, which are crucial in various industries such as textiles, printing, and painting.
Used in Organic Chemicals Production:
Beyond pharmaceuticals, dyes, and pigments, 2-[(4-methylphenyl)sulfonyl]aniline also finds application in the broader production of organic chemicals. Its role as a building block in organic synthesis extends to the creation of a diverse range of chemical products, highlighting its multifaceted utility in the chemical industry.

Upstream product

• 1220-92-4 1-nitro-2-tosylbenzene 
• 88-73-3 2-Chloronitrobenzene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 68-34-8 phenyl toluenesulfonamide 
• 6380-05-8 N-tosyl-2-chloroaniline 
• 916347-55-2 C₁₃H₁₃NO₂S*C₄₂H₇₀O₃₅ 
• 615-43-0 2-iodophenylamine 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 1493-27-2 ortho-nitrofluorobenzene 
• 98-59-9 p-toluenesulfonyl chloride 
• 20912-17-8 2-(4-methylphenylsulfanyl)nitrobenzene 
• 536-57-2 p-toluene sulfinic acid 
• 528-29-0 1,2-Dinitrobenzene 
• 861375-30-6 nitroso-phenyl-[2-(toluene-4-sulfonyl)-phenyl]-amine 

Downstream Products

• 61174-45-6 2-Azidophenyl-4-tolylsulfon 
• 1236-18-6 2-p-Toluolsulfonyl-benzolazocarbonsaeure-ethylester 
• 1216-90-6 2-p-Toluolsulfonyl-phenylhydrazin 
• 107624-65-7 o-chlorophenyl p-tolyl sulfone 

Relevant articles and documents

TosMIC and its derivatives as versatile sulfonylating agents for the synthesis of p-toluenesulfonylarenes from aryl halides and arylboronic acids

An efficient copper(II) catalyzed sulfonyation of aryl halides has been achieved using TosMIC (p-toluenesulfonylmethyl isocyanide) as a sulfonylating agent. This newly developed sulfonylation approach provides an easy access for the synthesis of diaryl sulfones from aryl bromides, iodides and boronic acids with TosMIC under neutral conditions. This method is useful for the sulfonylation of aryl boronic acids under similar conditions. This is the first report on the sulfonylation of aryl bromides, iodides and boronic acids using TosMIC.

ARYL-SULFONAMIDE AND ARYL-SULFONE DERIVATIVES AS TRPML MODULATORS

The new arylsulfonamide and arylsulfone derivatives are modulators of TRPML and are useful in treating disorders related to TRPML activities and lysosome functions such as acid-related disorders and cancer.

Copper-mediated sulfonylation of aryl iodides and bromides with arylsulfonyl hydrazides in PEG-400

Sulfonylation using stable and readily available arylsulfonyl hydrazides and aryl iodides or bromides mediated by cupric acetate has been achieved. Using polyethylene glycol (PEG-400) as an eco-friendly medium, the coupling reaction could afford a series of unsymmetrical diaryl sulfones in moderate to good yields without the presence of additional ligands and base.

Regioselectivity control of radiation-induced reaction: Electron beam-induced Fries rearrangement of sulfonamide within a β-cyclodextrin inclusion complex

EB (electron beam) irradiation of sulfonamide within a β-cyclodextrin (β-CD) inclusion complex in the solid state induced the solvent-free Fries rearrangement, which proceeded at a shorter reaction time with reversed regioselectivity by inclusion into the β-CD, compared with that of sulfonamide crystals; the β-CD as a restricted nanospace had a large effect on the reactivity and regioselectivity of the solvent-free EB-Fries rearrangement. The Royal Society of Chemistry 2006.

Electron beam-induced fries rearrangement of sulfonamide and sulfonate crystals

The electron beam (EB) sensitivity of sulfonic acid derivatives in the crystalline state was much higher than that of the corresponding carboxylic acid derivatives, which was distinct from the results using other energy sources such as heat and UV; especially, sulfonamide derivatives could undergo the chemoselective Fries rearrangement to give ortho and para products in the ratio of ca. 7/3 without the meta isomer. Copyright

Photo-Fries rearrangement of N-arylsulfonamides to aminoaryl sulfone derivatives

Photochemical reaction of variously substituted p-toluenesulfonanilides was studied. The reaction gives rearranged products, o- and p-amino-substituted diaryl sulfones with the combined yields of 38-72%: the p-isomer is more favored over the o-isomer with the selectivity ratio of 1.1-4.3 depending on the substituents. N-Alkylation of the sulfonanilides increases the yields of the rearranged products, and e-withdrawing substituents on the N-phenyl ring does not lower the yields drastically. This study provides simple methodology for the synthesis of o- and p-aminoaryl sulfones which are otherwise not easily accessible.