121885-10-7

Basic information

• Product Name: N-T-BUTYL PYRAZINE CARBOXAMIDE
• Synonyms: N-T-BUTYL PYRAZINE CARBOXAMIDE;N-(tert-butyl)pyrazine-2-carboxamide
• CAS NO: 121885-10-7
• Molecular Formula: C9H13N3O
• Molecular Weight: 179.22
• Product Categories: Pyrazines
• Mol File: 121885-10-7.mol

Chemical Properties

• Boiling Point: 361.268 °C at 760 mmHg
• Flash Point: 172.289 °C
• Appearance: /
• Density: 1.081 g/cm³
• PKA: 13.61±0.46(Predicted)
• CAS DataBase Reference: N-T-BUTYL PYRAZINE CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-T-BUTYL PYRAZINE CARBOXAMIDE(121885-10-7)
• EPA Substance Registry System: N-T-BUTYL PYRAZINE CARBOXAMIDE(121885-10-7)

Safety Data

• Hazardous Substances Data: 121885-10-7(Hazardous Substances Data)

Upstream product

• 19847-10-0 pyrazinoyl chloride 
• 75-64-9 tert-butylamine 
• 306990-94-3 (1H-benzo[d][1,2,3]triazol-1-yl)(pyrazin-2-yl)methanone 
• 201230-82-2 carbon monoxide 
• 32111-21-0 2-iodopyrazine 
• 98-97-5 2-pyrazylcarboxylic acid 
• 19847-12-2 2-pyrazine carbonitrile 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 143769-17-9 3-phenylhydroxymethyl-2-N-t-butylpyrazinamide 
• 150323-35-6 t-butyl (S)-3-(tert-butylcarbamoyl)-piperazine-1-carboxylate 
• 158380-45-1 (S)-3-tert-Butylcarbamoyl-4-(R)-1-oxiranylmethyl-piperazine-1-carboxylic acid tert-butyl ester 
• 150323-38-9 [14C]-N-Dealkyl Indinavir 
• 150378-17-9 indinavir 
• 166740-50-7 (S)-4-[(2S,4R)-4-Benzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-3-tert-butylcarbamoyl-piperazine-1-carboxylic acid tert-butyl ester 
• 166941-47-5 2(S)-(tert-butylcarboxamido)piperazine 

Relevant articles and documents

Homogeneous catalytic aminocarbonylation of nitrogen-containing iodo-heteroaromatics. Synthesis of N-substituted nicotinamide related compounds

Various primary and secondary amines, including amino acid methyl esters, were used as nucleophiles in palladium-catalysed aminocarbonylation of 2-iodopyridine, 3-iodopyridine and iodopyrazine. N-Substituted nicotinamides and 3-pyridyl-glyoxylamides (2-oxo-carboxamide type derivatives) of potential biological importance can be obtained from 3-iodopyridine as a result of simple and double carbon monoxide insertions, respectively. The latter examples can be obtained in synthetically acceptable yields by using elevated carbon monoxide pressure. On the contrary, N-alkyl/aryl-carboxamides were obtained exclusively in the whole pressure range by using 2-iodopyridine and iodopyrazine.

Amide derivative

A compound of the formula: wherein Ar is optionally substituted phenyl, etc.; n is 0, 1 or 2; R1is hydogen atom, optionally substituted alkyl, etc.; R2and R3are independently optionally substituted alkyl, etc.; R4and R5are independently hydrogen atom or optionally substituted alkyl; R6is hydrogen atom, hydroxy or alkyl; or a pharmaceutically acceptable salt thereof is useful as a medicament for treating retinal degenerative disorders and the like.

N-acylbenzotriazoles: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides

Readily available N-acylbenzotriazoles 2a-q efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in good to excellent yields. The wide applicability of the procedure is illustrated by the preparation of (i) α-hydroxyamides from α-hydroxy acids and of (ii) perfluoroalkylated amides.

Process for the preparation of optically active piperazine-2-carboxylic acid derivatives

Optically active piperazine-2-carboxylic acid derivatives of the general formula: STR1 in which X is alkoxy or a (substituted) amino group, are prepared by asymmetric hydrogenation of the corresponding pyrazinecarboxylic acid derivatives, catalyzed by optically active rhodium complexes. The compounds of the formula I are intermediates for the preparation of pharmaceutical active substances, for example, HIV protease inhibitors.

Process for preparing N-tert-butyl-2-pyrazinecarboxamide and N-tert-butyl-2-piperazinecarboxamide

A process for preparing a N-tert-butyl-2-pyrazinecarboxamide having the formula (2): STR1 which comprises reacting a cyanopyrazine having the formula (1): STR2 with tert-butyl alcohol in the presence of sulfuric acid and a process for preparing a N-tert-butyl-2-piperazine-carboxamide having the formula (3): STR3 which comprises hydrogenating of said N-tert-butyl-2-pyrazinecarboxamide having the formula (2) in the presence of Raney nickel or Raney cobalt.

Highly Diastereoselective Reaction of a Chiral, Non-Racemic Amide Enolate with (S)-Glycidyl Tosylate. Synthesis of the Orally Active HIV-1 Protease Inhibitor L-735,524

Reaction of chiral amide enolate Li-1 with (S)-glycidyl tosylate 11 affords the epoxide 3 in 72percent yield with high diastereoselectivity.Epoxide 3 is converted to the orally-active HIV-1 protease inhibitor L-735,524 in 71percent isolated yield.