1222106-43-5

Usage

Uses

Used in Pharmaceutical Industry:
7-Benzyl-4,7-diazaspiro[2.5]octane-5,8-dione is used as a potential drug candidate for its neuroprotective effects and anti-inflammatory properties. Its pharmacological properties make it a valuable target for the development of new therapeutic agents.
Used in Medicinal Chemistry Research:
7-Benzyl-4,7-diazaspiro[2.5]octane-5,8-dione serves as an interesting target for researchers in the field of medicinal chemistry. Its unique structure and properties offer opportunities for further exploration and development of novel drug candidates with potential therapeutic applications.

Upstream product

• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 84677-06-5 (benzyloxycarbonylamino)cyclopropanecarboxylic acid 
• 100-46-9 benzylamine 
• 108994-30-5 N-benzyl-glycyl chloride ; hydrochloride 
• 17136-36-6 N-benzylglycine 

Downstream Products

• 1222106-45-7 7-benzyl-4,7-diazaspiro[2.5]octane 
• 1222106-47-9 7-Benzyl-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane 
• 1235576-26-7 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane 
• 1235575-91-3 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane 
• 1235576-07-4 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4-methyl-4,7-diazaspiro[2.5]octane 
• 99214-52-5 4,7-diazaspiro[2.5]octane 
• 2173992-48-6 tert-butyl 4,7-diazaspiro[2.5]octane-4-carboxylate oxalate 

Relevant academic research and scientific papers

Preparation method of 4,7-diazaspiro[2.5]octane derivative

The invention provides a preparation method of 4,7-diazaspiro[2.5]octane derivative. The 4,7-diazaspiro[2.5]octane derivative is prepared by taking 1-aminocyclopropane carboxylate as a starting material. The preparation method has the advantages of simple operation steps, stable process conditions, high controllability, high product yield (the four-step reaction yield of compounds shown as formulas II to I can be up to 70 percent), environmental friendliness and the like, and is suitable for large-scale production.

PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272

Object of the present invention is an improved process for the preparation of cyclopropyldiketopiperazines and thereof key intermediates.

Sulfamide derivative and application thereof

The invention relates to a sulfamide derivative and a pharmaceutical composition comprising the compound as well as use of the sulfamide derivative and the pharmaceutical composition as a preparation drug, in particular, use of a drug for preparing a BCL-2 family protein antagonist and use of the drug for treating cancers.

IMIDAZOTHIAZOLE DERIVATIVE HAVING PROLINE RING STRUCTURE

[Problem to be Solved] There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. [Solution] The present invention provides an imidazothiazole derivative rep

MORPHOLINOPURINE DERIVATIVES

There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.