123577-99-1Relevant articles and documents
An efficient approach for enhancing the catalytic activity of Ni-MOF-74: Via a relay catalyst system for the selective oxidation of benzylic C-H bonds under mild conditions
Guo, Changyan,Zhang, Yonghong,Zhang, Yi,Wang, Jide
supporting information, p. 3701 - 3704 (2018/04/17)
Although nickel-based materials exhibit similar catalytic activity to palladium in organic synthesis, the selective oxidation of inert C-H bonds in the absence of other co-catalysts remains a largely unsolved challenge. This paper introduces a facile and efficient approach for enhancing the catalytic activity of Ni-MOF-74 with [bmim]Br via a relay catalysis strategy, which is excellent for the selective oxidation of benzylic C-H bonds. Notably, the catalyst recycling and scale up experiments demonstrated the practicability of the protocol. This method combines the catalytic advantages of MOFs and ionic liquids (ILs), and provides an insight into oxidation reactions by cheap and efficient Ni-based catalysts.
A selective, efficient and environmentally friendly method for the oxidative cleavage of glycols
García, Nuria,Rubio-Presa, Rubén,García-García, Patricia,Fernández-Rodríguez, Manuel A.,Pedrosa, María R.,Arnáiz, Francisco J.,Sanz, Roberto
, p. 2335 - 2340 (2016/05/19)
A catalytic methodology for the oxidative cleavage of vicinal diols is described as an advantageous alternative in terms of the environmental impact on classical methods involving toxic oxidants. The novel strategy is based on the use of dioxomolybdenum(vi) complexes as catalysts and dimethyl sulfoxide (DMSO) as an oxidant and displays high selectivity and a broad scope for glycol cleavage. In addition, the developed system is also useful for the oxidation of acyloins to diketones.
THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
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Paragraph 1098; 1099, (2014/07/23)
The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
Practical asymmetric synthesis of a chiral piperazinone derivative
McLaughlin, Mark,Belyk, Kevin,Chen, Cheng-Yi,Linghu, Xin,Pan, Jun,Qian, Gang,Reamer, Robert A.,Xu, Yingju
, p. 1052 - 1060 (2013/09/12)
A practical asymmetric route to a chiral piperazinone derivative, a fragment of MK-3207, is reported. The amine-bearing benzylic stereocenter is introduced via an asymmetric Pd-catalyzed hydrogenation of a cyclic sulfimidate in the presence of a chiral phosphine ligand. An efficient synthesis of the hydrogenation substrate is described, together with process development of the hydrogenation step and elaboration of the resulting cyclic sulfamate product to the desired piperazinone.
One-pot one-step deracemization of amines using ω-transaminases
Shin, Giyoung,Mathew, Sam,Shon, Minsu,Kim, Byung-Gee,Yun, Hyungdon
, p. 8629 - 8631 (2013/09/23)
In this study, we developed a one-pot one-step deracemization method for the production of various enantiomerically pure amines using two opposite enantioselective ω-TAs. Using this method, various aromatic amines were successfully converted to their (R)-forms (>99%) with good conversion.
Electrophilicities of symmetrically substituted 1,3-diarylallyl cations
Troshin, Konstantin,Schindele, Claus,Mayr, Herbert
experimental part, p. 9391 - 9408 (2012/01/06)
Kinetics of the reactions of nine symmetrically substituted 1,3-diarylallyl cations with different nucleophiles were studied photometrically in dichloromethane, acetonitrile, and DMSO solutions. The second-order rate constants k2 were found to follow the correlation log k2 = sN(N + E). The electrophilicity parameters E of the title cations were derived, using the known values of sN and N of the nucleophilic reaction partners, and compared with the electrophilicities of analogously substituted benzhydrylium ions. Good linear correlations were found between the electrophilicities E and the quantum chemically calculated gas-phase methyl anion affinities of the allyl cations and the σ+ constants of the substituents X.
Bisphosphonic acid derivatives as anti-arthritic agents
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, (2008/06/13)
The bisphosphonates of formula (III) bicyclic bisphosphonates (V), and cyclic bisphosphonates (VII) are useful as anti-arthritic agents and do not have the side effects of anti-arthritic agents which are prostaglandin synthetase inhibitors.
