1609373-95-6

Basic information

• Product Name: 3-(2,3-dimethoxyphenyl)-6-methylpyridin-2-amine
• Synonyms: 3-(2,3-dimethoxyphenyl)-6-methylpyridin-2-amine
• CAS NO: 1609373-95-6
• Molecular Weight: 244.293
• Mol File: 1609373-95-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(2,3-dimethoxyphenyl)-6-methylpyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,3-dimethoxyphenyl)-6-methylpyridin-2-amine(1609373-95-6)
• EPA Substance Registry System: 3-(2,3-dimethoxyphenyl)-6-methylpyridin-2-amine(1609373-95-6)

Safety Data

• Hazardous Substances Data: 1609373-95-6(Hazardous Substances Data)

Upstream product

• 40972-86-9 (2,3-dimethoxyphenyl)boronic acid 
• 126325-46-0 2-amino-3-bromo-6-methyl-pyridine 
• 958357-86-3 2-amino-5-bromo-3-iodo-6-methylpyridine 
• 42753-71-9 5-bromo-6-methyl-pyridin-2-ylamine 
• 1824-81-3 2-Amino-6-methylpyridine 

Downstream Products

• 1609373-98-9 2-methylbenzofuran[2,3-b]pyridin-8-yl-trifluoromethanesulfonate 
• 1609373-99-0 1,2-methyl-8-(2-pyridine)benzofuran[2,3-B]pyridine 
• 1609374-04-0 2-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridine 

Relevant articles and documents

Synthesis method of nitrogen-containing deuterated methyl compound

The invention discloses a synthesis method of a nitrogen-containing deuterated methyl compound. The method comprises the following steps: 2-amino-6-methylpyridine used as an initial raw material reacts with an aprotic solution of N-bromosuccinimide, separation is performed to obtain a compound 1, the compound 1 is subjected to an iodination reaction, palladium catalysis, cyclization, hydroxyl trifluoromethanesulfonic acid anhydridization and a deuteration reaction, and then extraction, organic phase mixing, saturated salt water washing, drying, spin-drying, column separation and other post-treatments to obtain the final product. The raw material has a low cost and is easy to obtain, so compared with other synthesis routes, the synthesis method of the nitrogen-containing deuterated methyl compound has the advantages of obvious reduction of the cost, good separation effect, few impurities, suitableness for large-scale production, and increase of the demethylation synthesis yield; the deuterated product can be effectively obtained through method, the deuteration rate can reach 97%, the production temperature is not higher than 100 DEG C to easily achieve safe production, and the practical value is high.