128790-14-7

Basic information

• Product Name: 2-(CHLOROMETHYL)-5-(TRIFLUOROMETHYL)PYRIDINE
• Synonyms: 2-(CHLOROMETHYL)-5-(TRIFLUOROMETHYL)PYRIDINE;2-(ChloroMethyl)-5-(trifluoroMethoxy)pyridine;5-trifluoroMethyl-pyridin-2-ylMethyl chloride
• CAS NO: 128790-14-7
• Molecular Formula: C7H5ClF3N
• Molecular Weight: 195.57
• EINECS: 604-604-1
• Mol File: 128790-14-7.mol

Chemical Properties

• Boiling Point: 198.1°C at 760 mmHg
• Flash Point: 73.6°C
• Appearance: /
• Density: 1.359g/cm³
• Vapor Pressure: 0.515mmHg at 25°C
• Refractive Index: 1.455
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(CHLOROMETHYL)-5-(TRIFLUOROMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-5-(TRIFLUOROMETHYL)PYRIDINE(128790-14-7)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-5-(TRIFLUOROMETHYL)PYRIDINE(128790-14-7)

Safety Data

• Hazardous Substances Data: 128790-14-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(Chloromethyl)-5-(trifluoromethyl)pyridine is used as a chemical intermediate for the synthesis of complex molecules. Its reactivity, particularly the chloromethyl group, enables it to be involved in substitution reactions, which is crucial for creating new compounds with potential therapeutic applications.
Used in Chemical Industry:
2-(Chloromethyl)-5-(trifluoromethyl)pyridine is used as a building block in the synthesis of various chemical compounds. Its unique structure and functional groups make it a valuable component in the development of new materials and products, such as agrochemicals, dyes, and other specialty chemicals. 2-(CHLOROMETHYL)-5-(TRIFLUOROMETHYL)PYRIDINE's versatility in chemical reactions allows for the creation of a wide range of derivatives with different properties and applications.

InChI:InChI=1/C7H5ClF3N/c8-3-6-2-1-5(4-12-6)7(9,10)11/h1-2,4H,3H2

Upstream product

• 100366-75-4 2‐iodo‐5‐(trifluoromethyl)pyridine 
• 31181-84-7 2-hydroxymethyl-5-trifluoromethylpyridine 
• 31224-82-5 5-(trifluoromethyl)pyridine-2-carbaldehyde 
• 128790-13-6 5-(trifluoromethyl)pyridine-2-carboxylic acid hydrochloride 
• 7664-93-9 sulfuric acid 
• 124-63-0 methanesulfonyl chloride 
• 31181-54-1 2-Methyl-5-(trifluoromethyl)pyridine 

Downstream Products

• 205313-15-1 [1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-{3-[(E)-2-(5-trifluoromethyl-pyridin-2-yl)-vinyl]-phenyl}-propylsulfanylmethyl)-cyclopropyl]-acetic acid methyl ester 

Relevant articles and documents

TEAD INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6 S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824)

New analogues of antitubercular drug PA-824 were synthesized, featuring alternative side chain ether linkers of varying size and flexibility, seeking drug candidates with enhanced metabolic stability and high efficacy. Both α-methyl substitution and removal of the benzylic methylene were broadly tolerated in vitro, with a biaryl example of the latter class exhibiting an 8-fold better efficacy than the parent drug in a mouse model of acute Mycobacterium tuberculosis infection and negligible fragmentation to an alcohol metabolite in liver microsomes. Extended linkers (notably propenyloxy, propynyloxy, and pentynyloxy) provided greater potencies against replicating M. tb (monoaryl analogues), with propynyl ethers being most effective under anaerobic (nonreplicating) conditions (mono/biaryl analogues). For benzyloxybenzyl and biaryl derivatives, aerobic activity was maximal with the original (OCH2) linker. One propynyloxy-linked compound displayed an 89-fold higher efficacy than the parent drug in the acute model, and it was slightly superior to antitubercular drug OPC-67683 in a chronic infection model.

A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair

The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singular) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists including 2ab (L-733,321) as an optimized candidate.

AZOLE DERIVATIVES

Azole derivatives of the formulas R1-CR2R3-CHR4-CR5R6-R7 are described; wherein R1 is a heterocyclyl radicla selected from 1,2,4-triazolyl, optionally-substituted imidazolyl, pyridyl and pyrimidinyl radicals; R2 and R3, which may be the same or differen