13089-11-7

Basic information

• Product Name: METHYL TRIFLUOROPYRUVATE
• Synonyms: METHYL TRIFLUOROPYRUVATE;METHYL 3,3,3-TRIFLUOROPYRUVATE;RARECHEM AL BF 1300;TRIFLUOROPYRUVIC ACID METHYL ESTER;Methyl trifluoropyruvate 97%;Methyltrifluoropyruvate97%;Methyl 3,3,3-trifluoropyruvate,97%;3,3,3-Trifluoropyruvic acid methyl ester
• CAS NO: 13089-11-7
• Molecular Formula: C₄H₃F₃O₃
• Molecular Weight: 156.06
• EINECS: 1312995-182-4
• Product Categories: C2 to C5;Carbonyl Compounds;Esters
• Mol File: 13089-11-7.mol

Chemical Properties

• Boiling Point: 86 °C(lit.)
• Flash Point: 80 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.529 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.332(lit.)
• Storage Temp.: Flammables area
• BRN: 1863490
• CAS DataBase Reference: METHYL TRIFLUOROPYRUVATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL TRIFLUOROPYRUVATE(13089-11-7)
• EPA Substance Registry System: METHYL TRIFLUOROPYRUVATE(13089-11-7)

Safety Data

• Hazard Codes: C,F,Xi
• Statements: 10
• Safety Statements: 45-36/37/39-26-16-24/25
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 13089-11-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl trifluoropyruvate is used as an intermediate compound for the synthesis of various pharmaceutical compounds, including:
1. 2-hydroxy-2-trifluoromethylbutan-4-olides
2. 2-(trifluoromethyl)butan-4-olides
3. 4-trifluoromethyl-(2H)-pyridazin-3-ones
4. Methyl 3-methoxy-2-trifluoromethylacrylate
These synthesized compounds have potential applications in the development of new drugs and therapies, making Methyl trifluoropyruvate a valuable component in the pharmaceutical industry.

Upstream product

• 10186-63-7 2-fluoro-2-methoxy trifluoropropanoic acid methyl ester 
• 67-56-1 methanol 
• 428-59-1 Hexafluoropropene oxide 
• 123202-05-1 Sodium; 2,3,3,3-tetrafluoro-2-methoxy-propionate 
• 532-32-1 sodium benzoate 

Downstream Products

• 126956-18-1 N-methyl-2-(1-methoxycarbonyl-1-hydroxy-2,2,2-trifluoroethyl)pyrrole 
• 132145-24-5 methyl 2-benzoylimino-3,3,3-trifluoropropionate 
• 114125-58-5 (+/-)-3,3,3-trifluoro-2-hydroxy-2-(indol-3-yl)propionic acid methyl ester 
• 107651-34-3 methyl α-hydroxy-α-benzenesulfamidotrifluoropropionate 
• 136308-19-5 4-Cyclohexylidene-2-hydroxy-2-trifluoromethyl-butyric acid methyl ester 
• 114155-18-9 3,3,3-Trifluoro-2-hydroxy-2-(2-phenyl-1H-indol-3-yl)-propionic acid methyl ester 
• 152450-52-7 methyl 3,3,3-trifluoro-2-hydroxy-2-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)propanoate 
• 114155-19-0 (+/-)-3,3,3-trifluoro-2-hydroxy-2-(1-methyl-2-phenylindol-3-yl)propionic acid methyl ester 
• 117015-45-9 methyl ester of 2-hydroxy-2-trifluoromethyl-4-pentenoic acid 
• 114645-33-9 dimethyl bis(trifluoromethyl)tartarate, meso form 
• 19607-29-5 dimethyl bis(trifluoromethyl)tartarate, racemate 
• 1493-11-4 trifluoromethanol 
• 88635-50-1 2-(trifluoroacetyloxy)-2-methyl-1-propyl radical 
• 115058-07-6 3-hydroxy-3-trifluoromethyl-2(3H)naphtho<1,2-b>furanone 

Related news

Arenesulfonylimines of METHYL TRIFLUOROPYRUVATE (cas 13089-11-7) in the cyclocondensation reactions with 1,3-C,N-and-N,N-binucleophiles09/29/2019

Reaction of arenesulfonylimines of methyl trifluoropyruvate with 1,3-C,N-and-N,N-binucleophiles led to a variety of N-sulfonylated fluorine-containing heterocycles, including the fused ones.detailed

Diethoxyphosphorylimine of METHYL TRIFLUOROPYRUVATE (cas 13089-11-7) in cyclocondensation with 1,3-C,N-and-N,N-binucleophiles09/28/2019

Reaction of diethoxyphosphorylimine of methyl trifluoropyruvate with 1,3-C,N-and-N,N-binucleophiles led to a variety of N-phosphorylated fluorine-containing heterocycles, including the fused ones.detailed

METHYL TRIFLUOROPYRUVATE (cas 13089-11-7) – a new solvent for the production of fluorinated organic resorcinol–formaldehyde aerogels10/01/2019

Resorcinol–formaldehyde aerogels obtained in methyl trifluoropyruvate (MTFP) possess a fluorinated matrix due to the mechanism of electrophilic substitution in the resorcinol moiety with the formation of C–C bond. The use of MTFP as a solvent also substantially accelerates the formaldehyde– r...detailed

METHYL TRIFLUOROPYRUVATE (cas 13089-11-7) Diethoxyphosphorylimine09/27/2019

The first example of trifluoropyruvate phosphorylimines was prepared, and its capability for O- and S-amidoalkylation of water, alcohols, and compounds with the SH function was shown. Phenol and 4-methoxyphenol are O-alkylated, while 3-dimethylaminophenol and indole undergo regiospecific C-alkyl...detailed

Green synthesis of METHYL TRIFLUOROPYRUVATE (cas 13089-11-7) catalyzed by solid acids09/25/2019

Solid acids – NiSO 4 /Al 2 O 3 , Fe 2 (SO 4 ) 3 /Al 2 O 3 and TiO 2 /SO 4 2− – appeared to be effective catalysts for the acid catalyzed synthesis of methyl ester of trifluoropyruvic acid. They are active at 15...detailed

Relevant articles and documents

Green synthesis of methyl trifluoropyruvate catalyzed by solid acids

Solid acids - NiSO4/Al2O3, Fe2(SO4)3/Al2O3 and TiO2/SO42- - appeared to be effective catalysts for the acid catalyzed synthesis of met

Methyl 3,3,3-trifluoropyruvate: An improved procedure starting from hexafluoropropene-1,2-oxide; identification of byproducts

Optimized laboratory-scale preparation of methyl 3,3,3-trifluoropyruvate (3, MTFP) has been developed starting from industrial hexafluoropropene-1,2-oxide (1, HFPO) via methyl 2,3,3,3-tetrafluoro-2-methoxypropanoate (2, MTPr), which was transformed to 3 using sulfuric acid with isolated yields up to 81%. Byproducts formed in the transformation of 2 to 3, viz. methyl trifluoroacetate (4, MTAc), methyl 3,3,3-trifluoropyruvate hydrate (5), methyl hemiacetal of trifluoropyruvate (6), a dimer of methyl 3,3,3-trifluoropyruvate hydrate (7, DimMTP), and methyl fluorosulfate (8, Sulf) were identified and their amounts determined under various experimental conditions. Potential reaction pathways leading to the formation of the byproducts are discussed.

UNUSUAL REACTION CHEMISTRY IN THERMAL DECOMPOSITION OF ALKALI METAL 2-ALKOXY-2,3,3,3-TETRAFLUOROPROPIONATE SALTS

Pyrolyses of several salts ROCF(CF3)CO2(-)M(+) (R=Me, Et, CF3CH2; M=Na, K, Cs) have been studied.The reaction chemistry shows highly unusual dependence on the nature of the alkoxy substituent and the metal cation.Product distribution are described along with some proposed mechanisms.