13169-73-8

Basic information

• Product Name: (4-fluorophenyl)(1H-pyrrol-2-yl)methanone
• Synonyms: (4-fluorophenyl)(1H-pyrrol-2-yl)methanone
• CAS NO: 13169-73-8
• Molecular Weight: 189.189
• Mol File: 13169-73-8.mol

Chemical Properties

• CAS DataBase Reference: (4-fluorophenyl)(1H-pyrrol-2-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-fluorophenyl)(1H-pyrrol-2-yl)methanone(13169-73-8)
• EPA Substance Registry System: (4-fluorophenyl)(1H-pyrrol-2-yl)methanone(13169-73-8)

Safety Data

• Hazardous Substances Data: 13169-73-8(Hazardous Substances Data)

Upstream product

• 109-97-7 pyrrole 
• 1978-65-0 4-(4-fluorobenzoyl)morpholine 
• 403-33-8 methyl 4-flurobenzoate 
• 20671-52-7 lithium pyrrolide 
• 459-57-4 4-fluorobenzaldehyde 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 403-43-0 4-fluorobenzoyl chloride 
• 2251-76-5 2-(4-fluorophenyl)-2-oxoacetic acid 

Downstream Products

• 129237-21-4 [1-(2-Chloromethyl-benzyl)-1H-pyrrol-2-yl]-(4-fluoro-phenyl)-methanone 
• 129055-81-8 (1-{2-[2-(4-Fluoro-benzoyl)-pyrrol-1-ylmethyl]-benzyl}-1H-pyrrol-2-yl)-(4-fluoro-phenyl)-methanone 
• 154047-01-5 (1-Allyl-1H-pyrrol-2-yl)-(4-fluoro-phenyl)-methanone 
• 154047-20-8 (1-Allyl-1H-pyrrol-2-yl)-(4-fluoro-phenyl)-methanol 
• 129055-86-3 11-(4-Fluoro-phenyl)-5H-benzo[e]pyrrolo[1,2-a]azepine 
• 1528751-50-9 ethyl {2-[(4-fluorophenyl)carbonyl]-1H-pyrrol-1-yl}acetate 

Relevant articles and documents

Synthesis method of 2-aromatic acyl pyrrole compounds

The invention relates to the field of organic synthesis, and discloses a synthesis method of 2-aromatic acyl pyrrole compounds, wherein the synthesis method comprises the steps: taking an N-aromatic acyl pyrrole compound as a raw material, and carrying ou

Aroylation of Electron-Rich Pyrroles under Minisci Reaction Conditions

The development of Minisci acylation on electron-rich pyrroles under silver-free neutral conditions has been reported featuring the regioselective monoacylation of (NH)-free pyrroles. Unlike conventional Minisci conditions, the avoidance of any acid that could result in the polymerization of pyrroles was the key to success. The umpolung reactivity of the nucleophilic acyl radical, generated in situ from arylglyoxylic acid, could help explain the mechanism of product formation with electron-rich pyrroles. Alternatively, the nucleophilic substitution of the acyl radical on the electron-deficient pyrrole radical cation is proposed.

Synthesis of a new compound family, 1-aryl-3H-pyrrolo[2,1-d][1,2,5] triazepin-4(5H)-ones

Representatives of a new family, 1-aryl-3H-pyrrolo[2,1-d][1,2,5]triazepin- 4(5H)-ones have been synthesized at our laboratory as bioisosters of biologically active 1-aryl-2,3-benzodiazepine-4-ones. The efficient synthetic route described applies the synth

Silver(I)-Catalyzed conia-ene reaction: Synthesis of 3-pyrrolines via a 5-endo-dig cyclization

A novel method has been developed for the synthesis of 3-pyrrolines from β-ketopropargylamines via a 5-endo-dig carbocyclization. This transformation involves a silver-catalyzed Conia-ene type reaction tolerating broad substrate scope with good to excellent yields. Furthermore, this methodology has been extended for the construction of 2-substituted pyrroles under base-mediated conditions. Copyright

A novel one-pot synthesis of 2-benzoylpyrroles from benzaldehydes

We herein report a novel one-pot reaction for benzoylation of pyrrole. The key step in the reaction is generation of di(1H-pyrrol-1-yl)zirconium(IV) chloride complex which reacts with benzaldehydes and methyl benzoates to give 2-benzoylpyrroles as the major product.

Ketopyrroles useful as ligands in organic iridium compositions

The present invention provides novel ketopyrroles having structure XXIV wherein R2 is independently at each occurrence a deuterium atom, a halogen, a nitro group, an amino group, a C3-C40 aromatic radical, a C1-C50 aliphatic radical, or a C3-C40 cyclcoaliphatic radical; “a” is an integer from 0 to 3; and X1 and X2 are independently at each occurrence a bromine atom, a hydroxy group, or the group OR10, and wherein the group R10 is independently at each occurrence a deuterium atom, a halogen, a nitro group, an amino group, a C3-C40 aromatic radical, a C1-C50 aliphatic radical, or a C3-C40 cyclcoaliphatic radical. Ketopyrroles XXIV are useful ligands for the preparation of Type (1) and Type (2) organic iridium compositions. In one aspect, the present invention provides deuterated analogs of XXIV. Organic iridium compositions are useful in the preparation optoelectronic devices, such as OLED devices and photovoltaic devices exhibiting enhanced performance characteristics.

Aromatic heterocycle compounds having HIV integrase inhibiting activities

A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORAwherein RAis hydrogen or ester residue, —CONRBRCwherein RBand RCeach is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1is optionally substituted heteroaryl; provided that a compound wherein Y and/or A1is optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.

Antifungal agents, II: Synthesis and antifungal activities of aryl-1H-pyrrol-2-yl-1H-imidazol-1-yl-methane derivatives with unsaturated chains

The synthesis and antifungal activities of aryl-1H-pyrrol-2-yl-1H-imidazol-1-yl-methanes having allyl, crotyl, and acrylate chains linked to the N-pyrrole atom and substituted at phenyl ring by Cl, F, CH3, and NO2 groups are reported