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Metronidazole Acetate is an imidazole derivative that serves as a protected form of Metronidazole (M338880). It exhibits anti-trichomonas, antifungal, and spermicidal properties, making it a versatile compound for various applications.

13182-82-6

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13182-82-6 Usage

Uses

Used in Pharmaceutical Industry:
Metronidazole Acetate is used as an active pharmaceutical ingredient for the treatment of various infections caused by protozoa, such as trichomoniasis, and anaerobic bacteria. Its antifungal and spermicidal properties also contribute to its use in this industry.
Used in Veterinary Medicine:
In the veterinary field, Metronidazole Acetate is used as a broad-spectrum antiprotozoal and antibacterial agent for the treatment of infections in animals.
Used in Contraceptives:
Due to its spermicidal activity, Metronidazole Acetate can be used in the development of contraceptive products to prevent pregnancy.
Used in Antifungal Treatments:
Metronidazole Acetate's antifungal properties make it suitable for use in treatments targeting fungal infections, both in humans and animals.
Used in Research:
As a pale yellow solid with unique chemical properties, Metronidazole Acetate can be utilized in research settings to study the effects of imidazole derivatives on various biological systems and to develop new therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 13182-82-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,8 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 13182-82:
(7*1)+(6*3)+(5*1)+(4*8)+(3*2)+(2*8)+(1*2)=86
86 % 10 = 6
So 13182-82-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H11N3O4/c1-6-9-5-8(11(13)14)10(6)3-4-15-7(2)12/h5H,3-4H2,1-2H3

13182-82-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-methyl-5-nitroimidazol-1-yl)ethyl acetate

1.2 Other means of identification

Product number -
Other names 1-acetoxy-2-(2-methyl-5-nitro-imidazol-1-yl)-ethane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13182-82-6 SDS

13182-82-6Relevant articles and documents

Imidazole derivatives as possible microbicides with dual protection

Kumar, Lalit,Sarswat, Amit,Lal, Nand,Sharma, Vishnu L.,Jain, Ashish,Kumar, Rajeev,Verma, Vikas,Maikhuri, Jagdamba P.,Kumar, Awanit,Shukla, Praveen K.,Gupta, Gopal

experimental part, p. 817 - 824 (2010/04/06)

Twenty seven derivatives (2-28) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol were synthesized and evaluated for anti-trichomonas, spermicidal and antifungal activities. Twenty six compounds were active against Trichomonas vaginalis at MIC ranging from 1-42 μM and seven compounds (9,18,19,22,24,26,28) immobilized 100% human spermatozoa at 1% concentration (w/v). Twenty three compounds (2,3,5,8-26,28) exhibited antifungal activity at 25-50 μg/mL concentration. Seven compounds (9,18,19,22,24,26,28) showed significant anti-trichomonas and spermicidal activities and also exhibited mild antifungal activity. All the compounds were highly safe towards human cervical cell line (HeLa) as shown by the cell-viability assay of HeLa cells at 200 μg/mL concentration, whereas nonoxynol-9 (N-9, the marketed spermicidal microbicide) was highly cytotoxic. Therefore, it may be concluded that introduction of the pharmacophore responsible for spermicidal activity into a proven anti-trichomonas structure may lead to a potent dual function microbicide better and safer than N-9.

Evaluation of lipophilicity, antimicrobial activity and mutagenicity of some novel ester prodrugs of metronidazole

Dubey, Sonal,Jain, Vinod,Precthi

experimental part, p. 1571 - 1576 (2010/04/02)

Various novel aliphatic and aromatic esters of metronidazole have been synthesized to improve the physicochemical properties (Rm values, lipophilicity) using prodrug approach. The alcoholic functional group of metronidazole is readily esterified, thus several novel ester prodrugs of metronidazole have been synthesized and evaluated for their anaerobic antibacterial activity and mutagenicity. These compounds have been characterized by UV, IR, 1H NMR, mass spectra and elemental analysis. The partition coefficient of esters is determined by n-octanol/water system, RP-TLC and computed in silico. Anaerobic-activity against C. perfringens. determined in terms of MIC (μg/ml) show the esters, particularly SDS-18 and SDS-19, to be more potent in comparison to metronidazole. The Ames test is used to compare the mutagenic potential of the synthesized 5-nitroimidazoles.

Pharmaceutical compositions primarily for the treatment and prevention of genitourinary infections and their extragenital complications

-

, (2008/06/13)

Compositions having synergistic effective amounts of one or more antibacterial agents, a nitroimidazole, and/or a sulfonamide or a molecule or compound having folic acid antagonist effect and nitroimidazole substitution in addition, with or without an ant

Lipophilic metronidazole derivatives and their absorption through hairless mouse skin

Masson,Thorsteinsson,Sigurdsson,Loftsson

, p. 369 - 371 (2007/10/03)

Previously we have shown that the diacyl glyceryl ester of naproxen is absorbed into excised mouse skin and slowly degraded to release naproxen. In the present work we have synthesised some organic acid and fatty acid derivatives of metronidazole, and studied the in-vitro degradation in aqueous buffer solutions and serum as well as their permeation through hairless mouse skin. The derivatives were enzymatically degraded in serum to form metronidazole. Only the acetic acid and butyric acid derivatives were able to permeate hairless mouse skin intact. The fatty acid derivatives released metronidazole within the skin. The metronidazole delivery through the skin was significant when the metronidazole oleate was used. This compound could therefore be considered as a suitable pro drug for dermal applications.

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