132911-42-3

Basic information

• Product Name: N-Methyl-1H-pyrrole-2-carboxamide
• Synonyms: N-Methyl-1H-pyrrole-2-carboxamide
• CAS NO: 132911-42-3
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14052
• Mol File: 132911-42-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: N-Methyl-1H-pyrrole-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-1H-pyrrole-2-carboxamide(132911-42-3)
• EPA Substance Registry System: N-Methyl-1H-pyrrole-2-carboxamide(132911-42-3)

Safety Data

• Hazardous Substances Data: 132911-42-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
N-Methyl-1H-pyrrole-2-carboxamide is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable building block for the development of new molecules with therapeutic and pesticidal activities.
Used in Material Science:
In the material science field, N-Methyl-1H-pyrrole-2-carboxamide is utilized in the production of polymers and coatings. Its incorporation into these materials can enhance their properties, such as durability, stability, and performance.
Used in Organic Synthesis:
N-Methyl-1H-pyrrole-2-carboxamide serves as a versatile building block in organic synthesis, allowing the development of new molecules with diverse properties and applications. Its reactivity and functional groups make it suitable for various chemical reactions, leading to the creation of innovative compounds.
Used in Antiviral and Anti-inflammatory Applications:
Due to its potential biological activities, N-Methyl-1H-pyrrole-2-carboxamide is being studied for its antiviral and anti-inflammatory properties. It may have the ability to inhibit viral replication and reduce inflammation, making it a promising candidate for the treatment of various diseases.

Upstream product

• 5427-82-7 1H-pyrrole-2-carbonyl chloride 
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• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 1072-83-9 2-Acetylpyrrole 
• 1217435-87-4 5-bromo-1H-pyrrole-2-carboxylic acid methylamide 
• 132911-43-4 4-bromo-1H-pyrrole-2-carboxylic acid methylamide 

Relevant articles and documents

Substrate Controlled Regioselective Bromination of Acylated Pyrroles Using Tetrabutylammonium Tribromide (TBABr3)

Electrophilic bromination of pyrroles bearing carbonyl substituents at C-2 typically results in a mixture of the 4- and 5-brominated species, generally favoring the 4-position. Herein, we describe a substrate-controlled regioselective bromination in which

Selective synthesis of N-substituted pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives via alkyne cyclization

A novel and efficient synthesis of N-substituted pyrrolo-pyrazinone derivatives has been developed. A trichloroacetyl group connected to the pyrrole ring was converted into the desired carboxamide derivatives. Promoted by NaH, the pyrrole carboxamide derivatives underwent a tandem reaction with propargyl bromide to afford pyrrolo-pyrazinones with high efficiency under very mild conditions. The mechanism for the formation of the products is discussed and supported by DFT calculations.

Acid catalyzed halogen dance on deactivated pyrroles

(Chemical Equation Presented) A study on the acid catalyzed halogen dance (ACHD) on deactivated bromopyrroles is reported. A different behavior is observed when considering singly deactivated pyrrole alkylcarboxamides, or doubly deactivated pyrroleketo-lactams (aldisines). Although less electron deficient pyrrole alkylcarboxamides suffer from ACHD, the double deactivation on keto-lactams disfavors pyrrole ring protonation thus preventing halogen scrambling. The mechanism involved in the rearrangement is hypothesized.

3-PYRROLYL-PYRIDOPYRAZOLES AND 3-PYRROLYL-INDAZOLES AS NOVEL KINASE INHIBITORS

Compounds of Formula (I) are useful as mediators of protein kinases and have activity as cell proliferation inhibitors where X, R1-R7 and R9 are as defined herein.

Alpha- haloenamine reagents

The present invention describes immobilized haloenamine reagents, immobilized tertiary amides, methods for their preparation, and methods of use.

Bioactive Bromopyrrole Metabolites from the Caribbean Sponge Agelas conifera

Biologically active extracts of the Carribean sponge Agelas conifera have yielded, in exhaustive studies, the diacetate salts of seven new bromopyrroles (1, 3-8), as well as that of the known debromooroidin dimer sceptrin (2).These compounds were found to be antiviral and antibacterial and were active in barnacle settlement and biochemical prophage induction assays.The structures assigned were based on spectroscopic comparison to sceptrin and two-dimensional NMR data.Synthetic bromopyrroles were used to verify bromine substitution patterns.The oxysceptrins (4, 5) are characterized by their aminoimidazolinone group, the ageliferins (6-8) by a unique cyclohexene-based skeleton.