135050-05-4

Basic information

• Product Name: N-(2-CHLORO-4-IODOPHENYL)ACETAMIDE
• Synonyms: N-(2-CHLORO-4-IODOPHENYL)ACETAMIDE
• CAS NO: 135050-05-4
• Molecular Formula: C₈H₇ClINO
• Molecular Weight: 295.50475
• Mol File: 135050-05-4.mol

Chemical Properties

• Boiling Point: 385.2 °C at 760 mmHg
• Flash Point: 186.8 °C
• Appearance: /
• Density: 1.887 g/cm³
• CAS DataBase Reference: N-(2-CHLORO-4-IODOPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLORO-4-IODOPHENYL)ACETAMIDE(135050-05-4)
• EPA Substance Registry System: N-(2-CHLORO-4-IODOPHENYL)ACETAMIDE(135050-05-4)

Safety Data

• Hazardous Substances Data: 135050-05-4(Hazardous Substances Data)

Usage

General Description

N-(2-chloro-4-iodophenyl)acetamide is a chemical compound with the chemical formula C8H8ClINO. It is a derivative of acetamide and contains a chloro and iodophenyl group attached to the nitrogen atom. N-(2-CHLORO-4-IODOPHENYL)ACETAMIDE is used in organic synthesis and pharmaceutical research as a building block for the creation of other chemical compounds. It is also used in the development of pharmaceutical drugs and agrochemicals due to its ability to act as a pharmacophore. As a chemical reagent, N-(2-chloro-4-iodophenyl)acetamide plays a role in the production of various functionalized compounds and is an important intermediate in the synthesis of organic molecules.

Upstream product

• 116008-49-2 4-(dichloroiodo)acetanilide 
• 42016-93-3 2-chloro-4-iodoaniline 
• 108-24-7 acetic anhydride 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 622-50-4 4-Acetamido-1-iodobenzene 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 42016-93-3 2-chloro-4-iodoaniline 
• 400610-30-2 1-(2-chloro-4-iodo-phenyl)-5-methyl-1H-tetrazole 

Relevant articles and documents

Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.

Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.

Monoprotected l-Amino Acid (l-MPAA), Accelerated Bromination, Chlorination, and Iodination of C(sp2)?H Bonds by Iridium(III) Catalysis

Halogenated arenes are important structural motifs commonly found in biologically active molecules and used for a variety of transformations in organic synthesis. Herein, we report the mono-protected l-amino acid (l-MPAA) accelerated iridium(III)-catalyzed halogenation of (hetero)anilides at room temperature. This reaction constitutes the first example of an iridium(III)/l-MPAA-catalyzed general halogenation of (hetero)arenes through C(sp2)?H activation. Furthermore, we demonstrate the potential utility of our method through its use in the synthesis of a quinolone derivative.

Silver(I)-catalyzed iodination of arenes: Tuning the lewis acidity of N-iodosuccinimide activation

A mild and rapid method for the iodination of arenes that utilizes silver(I) triflimide as a catalyst for activation of N-iodosuccinimide has been developed. The transformation was found to be general for a wide range of anisole, aniline, acetanilide, and phenol derivatives and allowed the late-stage iodination of biologically active compounds such as PIMBA, a SPECT imaging agent of breast cancer, and (a?)-IBZM, a dopamine D2 receptor antagonist. The method was also modified for the radioiodination of arenes using a one-pot procedure involving the in situ generation of [125I]-N-iodosuccinimide followed by the silver(I)-catalyzed iodination.

Tetrazolyl-phenyl acetamide glucokinase activators

Tetrazolyl-phenyl acetamides are active as glucokinase activators, and are able to increase insulin secretion, which makes them useful for treating type II diabetes.

Tetrazolyl-phenyl acetamide glucokinase activators

Tetrazolyl-phenyl acetamides are active as glucokinase activators, and are able to increase insulin secretion, which makes them useful for treating type II diabetes.