136816-76-7 Usage
Indole ring
A five-membered aromatic ring with a nitrogen atom at one position, contributing to the compound's aromaticity and potential pharmacological activity.
Piperazine ring
A six-membered nitrogen-containing ring, which is part of the compound's core structure and may contribute to its ability to interact with biological targets.
Ketone functional group
A carbonyl group (C=O) bonded to an aromatic ring, which can contribute to the compound's reactivity and potential pharmacological activity.
Propan-2-ylamino substituent
A branched amino group attached to the pyridine ring, adding complexity to the compound's structure and potentially affecting its interactions with biological targets.
Potential pharmacological activity
The presence of multiple aromatic rings and a ketone functional group suggests that 1H-indol-2-yl{4-[3-(propan-2-ylamino)pyridin-2-yl]piperazin-1-yl}methanone may have interactions with various biological targets, making it a potential candidate for medicinal chemistry research or drug development.
Interest for medicinal chemistry research
Due to its intricate structure and the presence of multiple nitrogen-containing rings, 1H-indol-2-yl{4-[3-(propan-2-ylamino)pyridin-2-yl]piperazin-1-yl}methanone may be of interest for further study in the field of medicinal chemistry, potentially leading to the development of new drugs or therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 136816-76-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,8,1 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 136816-76:
(8*1)+(7*3)+(6*6)+(5*8)+(4*1)+(3*6)+(2*7)+(1*6)=147
147 % 10 = 7
So 136816-76-7 is a valid CAS Registry Number.
136816-76-7Relevant articles and documents
Anti-aids piperazines
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, (2008/06/13)
The present invention includes diaromatic substituted heterocyclic compounds (III) STR1 which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).
Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors
Romero,Morge,Biles,Berrios-Pena,May,Palmer,Johnson,Smith,Busso,Tan,Voorman,Reusser,Althaus,Downey,So,Resnick,Tarpley,Aristoff
, p. 999 - 1014 (2007/10/02)
A variety of analogues of 1-[4-methoxy-3,5-dimethylbenzyl]-4-[3- (ethylamino)-2-pyridyl]piperazine hydrochloride (U-80493E) were synthesized and evaluated for their inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Replacement of the substituted aryl moiety with various substituted indoles provided bis(heteroaryl)piperazines (BHAPs) that were 10-100-fold more potent than U-80493E. The pyridyl portion of the lead molecule was found to be very sensitive to modifications. Extensive preclinical evaluations of several of these compounds led to the selection of 1-[(5-methoxyindol-2-yl)carbonyl]-4-[3-(ethylamino)-2- pyridyl]piperazine methanesulfonate (U-87201E, atevirdine mesylate) for clinical evaluation.
