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5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER is a chemical compound that belongs to the class of indole derivatives. It is a methyl ester of 5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid, characterized by its unique structure and potential medicinal properties.

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  • 136818-52-5 Structure
  • Basic information

    1. Product Name: 5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER
    2. Synonyms: 5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER;Methyl 5H-[1,3]dioxolo[4,5-f]indole-6-carboxylate
    3. CAS NO:136818-52-5
    4. Molecular Formula: C11H9NO4
    5. Molecular Weight: 219.19
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 136818-52-5.mol
  • Chemical Properties

    1. Melting Point: 194-195 °C(Solv: ethanol (64-17-5); water (7732-18-5))
    2. Boiling Point: 400.7±40.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.452±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 14.90±0.20(Predicted)
    10. CAS DataBase Reference: 5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER(136818-52-5)
    12. EPA Substance Registry System: 5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER(136818-52-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 136818-52-5(Hazardous Substances Data)

136818-52-5 Usage

Uses

Used in Organic Synthesis:
5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER is used as a key intermediate in organic synthesis for the development of various chemical compounds and materials.
Used in Pharmaceutical Research:
5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER is used as a research compound in pharmaceutical research for its potential medicinal properties and its application in the treatment of various diseases.
Used in Drug Development:
5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER is used as a potential drug candidate in drug development, given its potential therapeutic effects and the need for further research to explore its full potential.
It is important to handle 5H-[1,3]DIOXOLO[4,5-F]INDOLE-6-CARBOXYLIC ACID METHYL ESTER with care and follow proper safety protocols when working with it due to its potential hazards.

Check Digit Verification of cas no

The CAS Registry Mumber 136818-52-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,8,1 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 136818-52:
(8*1)+(7*3)+(6*6)+(5*8)+(4*1)+(3*8)+(2*5)+(1*2)=145
145 % 10 = 5
So 136818-52-5 is a valid CAS Registry Number.

136818-52-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid methyl ester

1.2 Other means of identification

Product number -
Other names Methyl 5H-[1,3]dioxolo[4,5-f]indole-6-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:136818-52-5 SDS

136818-52-5Relevant articles and documents

Ligand-free copper-catalyzed one-pot synthesis of indole-2-carboxylic esters

Zhu, Zhiqiang,Yuan, Jiangjun,Zhou, Yirong,Qin, Yang,Xu, Jingshi,Peng, Yiyuan

supporting information, p. 511 - 514 (2014/02/14)

A simple, efficient, and facile synthetic route for the preparation of indole-2-carboxylic esters was described. The cascade reactions of 2-bromobenzaldehyde and glycine ester hydrochloride were promoted by Cu 2O and a base to provide the corresponding products in good yields. Commercially available, inexpensive substrates and reagents were employed under mild reaction conditions in this one-pot operation, which is complementary to existing methods for access to 2-substituted indoles. A simple, efficient, and facile synthetic route to indole-2-carboxylic esters through copper-catalyzed one-pot cascade reactions of commercially available, inexpensive 2-bromobenzaldehyde and glycine ester hydrochloride without the use of any external ligand under mild conditions is reported. Copyright

Ligand-Free Copper-Catalyzed One-Pot Synthesis of Indole-2-carboxylic Esters

Zhu, Zhiqiang,Yuan, Jiangjun,Zhou, Yirong,Qin, Yang,Xu, Jingshi,Peng, Yiyuan

supporting information, p. 511 - 514 (2015/10/05)

A simple, efficient, and facile synthetic route for the preparation of indole-2-carboxylic esters was described. The cascade reactions of 2-bromobenzaldehyde and glycine ester hydrochloride were promoted by Cu2O and a base to provide the corresponding products in good yields. Commercially available, inexpensive substrates and reagents were employed under mild reaction conditions in this one-pot operation, which is complementary to existing methods for access to 2-substituted indoles.

Gold(I)-catalyzed rearrangement of alkynylaziridine indoles for the synthesis of spiro-tetrahydro-β-carbolines

Yang, Yan-Fang,Li, Lian-Hua,He, Yu-Tao,Luo, Jian-Yi,Liang, Yong-Min

, p. 702 - 707 (2014/02/14)

Functionalized spiro-tetrahydro-β-carbolines were formed by an efficient gold(I)-catalyzed rearrangement reaction of alkynylaziridine indoles. The reaction involved a Friedel-Crafts type intramolecular reaction of alkynylaziridine indoles, following by hydroamination of aminoallene intermediate.

Iron(II) triflate as a catalyst for the synthesis of indoles by intramolecular C-H amination

Bonnamour, Julien,Bolm, Carsten

, p. 2012 - 2014 (2011/06/28)

A practical iron-catalyzed intramolecular C-H amination reaction and its application in the synthesis of indole derivatives are presented. As a catalyst, commercially available iron(II) triflate is used.

[Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation for alkaloid synthesis using aryl azides as nitrogen source

Liu, Yungen,Wei, Jinhu,Che, Chi-Ming

supporting information; experimental part, p. 6926 - 6928 (2010/11/16)

The syntheses of alkaloids including indoles, indolines, tetrahydroquinolines, dihydroquinazolinones and quinazolinones have been accomplished in moderate to excellent yields via [Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation using aryl azides as nitrogen source.

Tandem palladium-catalyzed N,C-coupling/carbonylation sequence for the synthesis of 2-carboxyindoles

Vieira, Tiago O.,Meaney, Laura A.,Shi, Yong-Ling,Alper, Howard

supporting information; experimental part, p. 4899 - 4901 (2009/05/31)

(Chemical Equation Presented) Tandem palladium-catalyzed N,C-coupling/carbonylation, under 10 aim of carbon monoxide and at 110 °C, is a novel and efficient method for the preparation of 2-carboxyindoles. The catalyst system tolerates a variety of functional groups, and the noted indoles were obtained in good isolated yields.

Hyperbranched molecular structures with potential antiviral activity: Derivatives of 5,6-dihydroxyindole-2-carboxylic acid

Sechi, Mario,Casu, Fabio,Campesi, Ilaria,Fiori, Stefano,Mariani, Alberto

, p. 968 - 977 (2007/10/03)

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requi

CBI analogues of the duocarmycins and CC-1065

-

Page 30, (2010/02/10)

An extensive series of CBI analogues of the duocarmycins and CC-1065 exploring substituent effects within the first indole DNA binding subunit is detailed. In general, substitution at the indole C5 position led to cytotoxic potency enhancements that can be ≧1000-fold providing simplified analogues containing a single DNA binding subunit that are more potent (IC50=2-3 pM) than CBI-TMI, duocarmycin SA, or CC-1065. The increases in cytotoxicity correlate well with accompanying increases in the rate and efficiency of DNA alkylation. This effect is more pronounced with the CBI versus DSA or CPI based analogues. Moreover, this effect is largely insensitive to the electronic character of the C5 substituent but is sensitive to the size, rigid length, and shape (sp, sp2, sp3 hybridization) of this substituent consistent with expectation that the impact is due simply to its presence.

Design and synthesis of novel indole β-diketo acid derivatives as HIV-1 integrase inhibitors

Sechi, Mario,Derudas, Massimiliano,Dallocchio, Roberto,Dessì, Alessandro,Bacchi, Alessia,Sannia, Luciano,Carta, Fabrizio,Palomba, Michele,Ragab, Omar,Chan, Carney,Shoemaker, Robert,Sei, Shizuko,Dayam, Raveendra,Neamati, Nouri

, p. 5298 - 5310 (2007/10/03)

Diketo acids such as S-1360 (1A) and L-731,988 (2) are potent and selective inhibitors of HIV-1 integrase (IN). A plethora of diketo acid-containing compounds have been claimed in patent literature without disclosing much biological activities and synthetic details (reviewed in Neamati, N. Exp. Opin. Ther. Pat. 2002, 12, 709-724). To establish a coherent structure - activity relationship among the substituted indole nucleus bearing a β-diketo acid moiety, a series of substituted indole-β-diketo acids (4a-f and 5a-e) were synthesized. All compounds tested showed anti-IN activity at low micromolar concentrations with varied selectivity against the strand transfer process. Three compounds, the indole-3-β-diketo acids 5a and 5c, and the parent ester 9c, have shown an antiviral activity in cell-based assays. We further confirmed a keto-enolic structure in the 2,3-position of the diketo acid moiety of a representative compound (4c) using NMR and X-ray crystallographic analysis. Using this structure as a lead for all of our computational studies, we found that the title compounds extensively interact with the essential amino acids on the active site of IN.

Anti-aids piperazines

-

, (2008/06/13)

The present invention includes diaromatic substituted heterocyclic compounds (III) STR1 which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).

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