138624-99-4

Basic information

• Product Name: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol
• Synonyms: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol
• CAS NO: 138624-99-4
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.1238496
• Mol File: 138624-99-4.mol

Chemical Properties

• Appearance: /Solid
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol(138624-99-4)
• EPA Substance Registry System: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol(138624-99-4)

Safety Data

• Hazardous Substances Data: 138624-99-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol is used as a key building block for the synthesis of various pharmaceuticals. Its incorporation into drug molecules can improve their efficacy and stability, making it a crucial component in the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol serves as an essential component in the production of agrochemicals. Its ability to enhance the biological activity and stability of these compounds contributes to the development of more effective and durable products for agricultural applications.
Used in Organic Synthesis:
2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol is utilized as a solvent and reagent in organic synthesis processes. Its unique properties facilitate various chemical reactions, making it a valuable asset in the synthesis of a wide range of organic compounds.
Safety Precautions:
Due to its flammability and potential health hazards, 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol should be handled and stored with proper safety measures. Adequate precautions must be taken to minimize risks associated with its use in research and industrial applications.

Upstream product

• 626-55-1 3-Bromopyridine 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 1120-90-7 3-iodopyridine 
• 807329-97-1 TurboGrignard 
• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 
• 500-22-1 3-pyridinecarboxaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 33284-21-8 3-(trifluoroacetyl)pyridine 
• 1099598-09-0 3-(2,2,2-trifluoroethyl)pyridine 

Relevant articles and documents

Fungicidal Pyridine Derivatives, IV. α-Trifluoromethyl-3-pyridinemethanols

The synthesis of a series of the title compounds is described applying the addition of 3-pyridyllithium to appropriate trifluoromethylalkanones (path 1) and addition of lithiumorganyls to 2,2,2-trifluoro-1-(3-pyridyl)-ethanone (path 2), respectively.Keywords.Fungicides; α-Trifluoromethyl-pyridinemethanols.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, lI-P, or III. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH).

One-Pot Successive Turbo Grignard Reactions for the Facile Synthesis of α-Aryl-α-Trifluoromethyl Alcohols

A novel straightforward one-pot methodology for two successive turbo Grignard reagent (iPrMgCl·LiCl) reactions, was developed for a facile synthesis of α-aryl-α-trifluoromethyl alcohols, motifs of value in pharmaceutical chemistry. The method displayed broad functional group tolerance, including reducible groups. Dual roles of iPrMgCl·LiCl were exploited in the tandem reaction with commercially available iodoarenes or iodoheteroarenes and 2,2,2-trifluoroethyl trifluoroacetate. The process encompasses three successive reactions in a one-pot process: the iPrMgCl·LiCl-mediated iodine/magnesium-exchange reaction of iodoarenes or iodoheteroarenes; nucleophilic addition of various generated aryl or heteroarylmagnesium reagents to 2,2,2-trifluoroethyl trifluoroacetate; and the reduction of in-situ generated aryl trifluoromethyl ketones with iPrMgCl·LiCl, to produce the corresponding α-aryl or α-heteroaryl-α-trifluoromethyl alcohols bearing various substituents, including reducible functional groups in good to excellent yields.

FLUOROALKYLATING AGENT

Problem to be Solved It is intended to provide an industrially preferable fluoroalkylating agent and use thereof. Solution The present invention provides a fluoroalkylating agent represented by the general formula (1) wherein R1 is a C1 to C8 fluoroalkyl group; R2 and R3 are each independently a C1 to C12 alkyl group or the like; Y1 to Y4 are each independently a hydrogen atom, a halogen atom, or the like; and X? is a monovalent anion. A compound of the general formula (3): R4—S—R1 having an introduced C1 to C8 fluoroalkyl group is easily obtained by reacting a compound of the general formula (2): R4—S—Z wherein R4 is a hydrocarbon group or the like; and Z is a leaving group, with the compound of the general formula (1).

TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Provided are quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, L, X 1, X 2, and X 3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.

Enzyme-catalyzed kinetic resolution of 2,2,2-trifluoro-1-(heteroaryl)ethanols: Experimental and docking studies

A convenient approach towards enantiopure (R) and (S) isomers of 2,2,2-trifluoro-1-(heteroaryl)ethanols was developed. The enzyme-catalyzed kinetic resolution of the corresponding racemic mixtures was achieved by using a two-step protocol that involved an

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE

The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R19, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).

KYNURENINE PRODUCTION INHIBITOR

Provided is a kynurenine production inhibitor comprising a nitrogen-containing heterocyclic compound represented by formula (I): (wherein R50 and R51 may be the same or different and each represent a hydrogen atom or the like, G1 and G2 may be the same or different and each represent a nitrogen atom or the like, X represents formula (III): (wherein m1 and m2 may be the same or different and each represent an integer of 0 or 1, Y represents an oxygen atom or the like, and R6 and R7 may be the same or different and each represent a hydrogen atom or the like), R1 represents optionally substituted lower alkyl or the like, R2 represents a hydrogen atom or the like, and R3 represents optionally substituted lower alkyl or the like), and the like.

Development of fluorination methods using continuous-flow microreactors

The safe and reliable use of various fluorination methods including nucleophilic fluorination (DAST), trifluoromethylation (Ruppert's reagent) and electrophilic fluorination (Selectfluor) in a continuous-flow microreactor is reported. Special a

Trifluoromethylation of carbonyl compounds with trifluoromethyltrimethylsilane (Ruppert reagent) promoted by triphenyldifluorostannates

Nucleophilic trifluoromethylation of aromatic aldehydes and ketones with trifluoromethyltrimethylsilane is initiated with KF/n-Bu3MeN +HSO4-/Ph3SnF cocatalytic system in CH2Cl2 or with K[Ph3SnF2] in DMF.