33284-21-8

Basic information

• Product Name: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI)
• Synonyms: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI);3-trifluoroacetypyridine;3-(Trifluoroacetyl)pyridine;2,2,2-trifluoro-1-(pyridin-3-yl)ethanone;2,2,2-trifluoro-1-(pyridin-3-yl)ethan-1-one;3-(Trifluoroacetyl)pyridine monohydrate;2,2,2-Trifluoro-1-(pyridin-3-yl);2,2,2-TRIFLUORO-1-(PYRIDIN-3-YL)ETHANONE HCL H2O
• CAS NO: 33284-21-8
• Molecular Formula: C7H4F3NO
• Molecular Weight: 175.1079696
• Product Categories: ACETYLHALIDE
• Mol File: 33284-21-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 197.93 °C at 760 mmHg
• Flash Point: 73.506 °C
• Appearance: /
• Density: 1.341 g/cm³
• Vapor Pressure: 0.369mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1?+-.0.10(Predicted)
• CAS DataBase Reference: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI)(33284-21-8)
• EPA Substance Registry System: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI)(33284-21-8)

Safety Data

• Hazardous Substances Data: 33284-21-8(Hazardous Substances Data)

Usage

Uses

3-(Trifluoroacetyl)pyridine is used as medical intermediates.

InChI:InChI=1/C7H4F3NO/c8-7(9,10)6(12)5-2-1-3-11-4-5/h1-4H

Upstream product

• 93-60-7 methyl 3-pyridinecarboxylate 
• 456-56-4 phenyl trifluoromethylsulfide 
• 59-67-6 nicotinic acid 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 75-46-7 trifluoromethan 
• 350-03-8 methyl-3-pyridylketone 
• 383-63-1 ethyl trifluoroacetate, 
• 626-55-1 3-Bromopyridine 
• 360-92-9 N,N-diethyl-2,2,2-trifluoroacetamide 
• 138624-99-4 2,2,2-trifluoro-1-(pyridin-3-yl)ethan-1-ol 

Relevant articles and documents

Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones

The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.

High-Pressure-Mediated Asymmetric Organocatalytic Hydroxyalkylation of Indoles with Trifluoromethyl Ketones

An enantioselective hydroxyalkylation of indoles and 7-azaindole with trifluoromethyl ketones was found to be effectively promoted under high-pressure conditions with a low loading of Cinchona alkaloids (e.g., 1–3 mol% of cinchonidine). Chiral tertiary alcohols containing a trifluoromethyl group were obtained at 9 kbar with good yield and enantioselectivity up to 89%, whereas usually merely traces of products were detected at atmospheric pressure. (Figure presented.).

Process for preparing alpha-halogenated retones

The invention concerns a method for preparing α-halogenated ketones from secondary α-halogenated alcohols. More particularly, the invention concerns the preparation of α-trihalogenated ketones from secondary α-trihalogenated alcohols. The method for prepa