Microwave Assisted Synthesis of Fused Thiazoles in Multicomponent System and Their in vitro Antitumor, Antioxidant, and Antimicrobial Activities
A novel series of thiazolopyrimidines, thiazolopyrimidinones, imidazolothiazoles, and 1-thiazole-5-pyrazolone was synthesized under microwave irradiation. Most of the synthesized compounds were screened in vitro antitumor, antioxidant, and antimicrobial activities.
El-Borai, Mohamed A.,Rizk, Hala F.,Ibrahim, Seham A.,El-Sayed, Hatem F.
SYNTHESIS AND PROPERTIES OF 1,3,4-THIADIAZINE DERIVATIVES. 1. INVESTIGATION OF THE CONDENSATION OF SUBSTITUTED PHENACYL BROMIDES AND BROMOACETYLPYRIDINES WITH THIOSEMICARBAZIDE
2-Amino-5-aryl(pyridyl)-6H-1,3,4-thiadiazines and isomeric 2-hydrazino-4-aryl(pyridyl)thiazoles, the ration of which depends on the reaction conditions, were obtained by the reaction of substituted phenacyl bromides and bromoacetylpyridines with thiosemicarbazide.
Novikova, A. P.,Perova, N. M.,Egorova, L. G.,Bragina, E. I.
p. 666 - 668
(2007/10/02)
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