4-(3-PYRIDINYL)-2(3H)-THIAZOLONE HYDRAZONE

Base Information

• Chemical Name: 4-(3-PYRIDINYL)-2(3H)-THIAZOLONE HYDRAZONE
• CAS No.: 139420-57-8
• Molecular Formula: C8H8N4S
• Molecular Weight: 192.24100
• Mol file: 139420-57-8.mol

Synonyms:2-hydrazino-4-(pyridine-3-yl)-1,3-thiazole;(4-Pyridin-3-yl-thiazol-2-yl)-hydrazine;1-(4-(pyridin-3-yl) thiazol-2-yl) hydrazine;2-Hydrazino-4-(3'-pyridyl)thiazole;

Chemical Property of 4-(3-PYRIDINYL)-2(3H)-THIAZOLONE HYDRAZONE

Chemical Property:

• PSA: 92.07000
• LogP: 2.26400

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-PYRIDINYL)-2(3H)-THIAZOLONE HYDRAZONE

There total 3 articles about 4-(3-PYRIDINYL)-2(3H)-THIAZOLONE HYDRAZONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-Bromoacetylpyridine (6221-12-1) + thiosemicarbazide (79-19-6) → 2-Amino-5-(3'-pyridyl)-6H-1,3,4-thiadiazine (139420-62-5) + 2-Hydrazino-4-(3'-pyridyl)thiazole (139420-57-8)

Guidance literature:

With hydrogen bromide; for 1h; Yields of byproduct given; Heating;

DOI:10.1007/BF00472523

Reference yield: 75.0%

4-(pyridin-3-yl)thiazol-2-amine (30235-27-9) → 2-Hydrazino-4-(3'-pyridyl)thiazole (139420-57-8)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

DOI:10.1002/jhet.2671

Reference yield: 64.0%

methyl-3-pyridylketone (350-03-8) + thiosemicarbazide (79-19-6) → 2-Hydrazino-4-(3'-pyridyl)thiazole (139420-57-8)

Guidance literature:

In ethanol; for 8h; Reflux;

DOI:10.1002/jhet.2671

upstream raw materials:

3-Bromoacetylpyridine

thiosemicarbazide

4-(pyridin-3-yl)thiazol-2-amine

methyl-3-pyridylketone

Refernces

• 1、 Novikova, A. P.,Perova, N. M.,Egorova, L. G.,Bragina, E. I.. "SYNTHESIS AND PROPERTIES OF 1,3,4-THIADIAZINE DERIVATIVES. 1. INVESTIGATION OF THE CONDENSATION OF SUBSTITUTED PHENACYL BROMIDES AND BROMOACETYLPYRIDINES WITH THIOSEMICARBAZIDE". . p. 666 - 668. Retrieved 2007/10/02.