14027-75-9

Basic information

• Product Name: 3-FLUORO-5-NITROBENZOIC ACID
• Synonyms: 3-FLUORO-5-NITROBENZOIC ACID;3-Fluoro-5-nitrobenzoic acid ,98%;Benzoic acid, 3-fluoro-5-nitro-
• CAS NO: 14027-75-9
• Molecular Formula: C₇H₄FNO₄
• Molecular Weight: 185.11
• Product Categories: Fluorine series
• Mol File: 14027-75-9.mol

Chemical Properties

• Melting Point: 125°C
• Boiling Point: 341.2 °C at 760 mmHg
• Flash Point: 160.1 °C
• Appearance: /Solid
• Density: 1.568 g/cm³
• Vapor Pressure: 3.16E-05mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.14±0.10(Predicted)
• CAS DataBase Reference: 3-FLUORO-5-NITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-5-NITROBENZOIC ACID(14027-75-9)
• EPA Substance Registry System: 3-FLUORO-5-NITROBENZOIC ACID(14027-75-9)

Safety Data

• Hazardous Substances Data: 14027-75-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-5-nitrobenzoic acid is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved properties, such as enhanced efficacy, selectivity, and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Fluoro-5-nitrobenzoic acid serves as a key intermediate in the production of various agrochemicals. Its incorporation into these compounds can lead to the development of more effective and environmentally friendly pesticides and herbicides.
Used as a Reagent in Organic Chemical Reactions:
3-Fluoro-5-nitrobenzoic acid is utilized as a reagent in a wide range of organic chemical reactions. Its presence can facilitate or enhance the reaction process, leading to the formation of desired products with higher yields and purity.
Used as a Building Block for the Preparation of Other Chemical Compounds:
Due to its unique structure and properties, 3-Fluoro-5-nitrobenzoic acid is employed as a building block for the preparation of various other chemical compounds. It can be used to synthesize a diverse array of molecules with potential applications in various fields, such as materials science, polymer chemistry, and medicinal chemistry.

InChI:InChI=1/C7H4FNO4/c8-5-1-4(7(10)11)2-6(3-5)9(12)13/h1-3H,(H,10,11)

Upstream product

• 618-84-8 3-amino-5-nitro-benzoic acid 
• 95-50-1 1,2-dichloro-benzene 
• 10472-88-5 4-fluoro-2-bromo-6-nitroaniline 
• 7087-65-2 1-bromo-3-fluoro-5-nitrobenzene 
• 364-78-3 2-nitro-4-fluoroaniline 
• 110882-60-5 3-fluoro-5-nitrobenzonitrile 

Downstream Products

• 1408282-26-7 6-fluoro-3,10-diazatricyclo[6.4.1.0^4,13]trideca-1,4⁽¹³⁾,5,7-tetraen-9-one 
• 883987-72-2 methyl 3-fluoro-5-nitrobenzoate 
• 914636-93-4 3-fluoro-5-iodobenzaldehyde 

Relevant articles and documents

Antibiotic compounds

The present invention relates to carbapenems and provides a compound of the formula (I): STR1 or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 and R5 are the same or different and are selected from hydrogen, halo, cyano, C1-4 alkyl, nitro, hydroxy, carboxy, C1-4 alkoxy, C1-4 alkoxycarbonyl, aminosulphonyl, C1-4 alkylaminosulphonyl, di-C1-4 alkylaminosulphonyl, carbamoyl, C1-4 alkylcarbamoyl, di-C1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C1-4 alkylamino, di-C1-4 alkylamino, C1-4 alkanoylamino, C1-4 alkanoyl(N-C1-4 alkyl)amino, C1-4 alkanesulphonamido and C1-4 alkylS(O)n -- wherein n is zero, one or two: with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the --NR2 --. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

Directed biosynthesis of 5'-fluoropactamycin in Streptomyces pactum

A new pactamycin analogue, 5'-fluoropactamycin, was prepared by directed biosynthesis. Supplementation of the fermentation medium of Streptomyces pactum, var. pactum with 3-amino-5-fluorobenzoic acid, an analogue of 3-aminobenzoic acid, an advanced precursor in pactamycin biosynthesis, resulted in co-production of pactamycin and the new pactamycin analogue. A similar feeding experiment with 3-amino-5-methylbenzoic acid did not result in formation of the corresponding methylated pactamycin analogue, but only in inhibition of pactamycin production. Comparison of antimicrobial and cytotoxic activities of pactamycin and 5'-fluoropactamycin showed no significant differences.