7087-65-2

Basic information

• Product Name: 5-AMINO-1-BROMO-3-FLUOROBENZENE
• Synonyms: 5-AMINO-1-BROMO-3-FLUOROBENZENE;1-Bromo-3-fluoro-5-nitrobenzene;3-Bromo-5-fluoroaniline;3-Bromo-5-fluoronitrobenzene 97%
• CAS NO: 7087-65-2
• Molecular Formula: C₆H₃BrFNO₂
• Molecular Weight: 190.01
• EINECS: 1533716-785-6
• Product Categories: Fluorine series
• Mol File: 7087-65-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 245.466 °C at 760 mmHg
• Flash Point: 102.255 °C
• Appearance: Yellow/Liquid
• Density: 1.695g/cm³
• Vapor Pressure: 0.041mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-AMINO-1-BROMO-3-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-BROMO-3-FLUOROBENZENE(7087-65-2)
• EPA Substance Registry System: 5-AMINO-1-BROMO-3-FLUOROBENZENE(7087-65-2)

Safety Data

• RIDADR: UN2810
• HazardClass: 6.1
• Hazardous Substances Data: 7087-65-2(Hazardous Substances Data)

Usage

General Description

5-AMINO-1-BROMO-3-FLUOROBENZENE is a chemical compound consisting of a benzene ring with an amino group, a bromine atom, and a fluorine atom attached to it. It is used in various chemical reactions and organic synthesis processes, serving as a building block for more complex molecules. 5-AMINO-1-BROMO-3-FLUOROBENZENE is known for its aromatic properties and its reactivity in substitution and addition reactions. It is also utilized in the pharmaceutical and agrochemical industries for the production of various drugs and pesticides. Additionally, 5-AMINO-1-BROMO-3-FLUOROBENZENE is a potential precursor in the synthesis of fluorescent dyes and imaging agents for medical and biological applications.

InChI:InChI=1/C6H3BrFNO2/c7-4-1-5(8)3-6(2-4)9(10)11/h1-3H

Upstream product

• 10472-88-5 4-fluoro-2-bromo-6-nitroaniline 
• 394-01-4 4-fluoro-2-nitrobenzoic acid 
• 364-78-3 2-nitro-4-fluoroaniline 

Downstream Products

• 110882-60-5 3-fluoro-5-nitrobenzonitrile 
• 134168-97-1 3-bromo-5-fluoroaniline 
• 710348-94-0 2-(3-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane 
• 1312923-89-9 3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorobenzene 

Relevant articles and documents

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted- phenyl series

We report the synthesis of four series of 3,5-disubstituted-phenyl ligands targeting the metabotropic glutamate receptor subtype 5: (2-methylthiazol-4-yl) ethynyl (1a-j,), (6-methylpyridin-2-yl)ethynyl (2a-j), (5-methylpyridin-2-yl) ethynyl (3a-j,), and (pyridin-2-yl)ethynyl (4a-j,). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro assay. All compounds were found to be full antagonists and exhibited low nanomolar to subnanomolar activity.

NMDA antagonists

The present invention is directed to a new class of 4-sulfanimide-quinoline derivatives and to their use as NMDA antagonists.