142102-74-7

Basic information

• Product Name: [(6R,8R,9R)-9-(acetyloxy)-4-amino-8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate
• CAS NO: 142102-74-7
• Molecular Formula: C₂₁H₂₁N₃O₁₀S
• Molecular Weight: 507.4705
• Mol File: 142102-74-7.mol

Chemical Properties

• Density: 1.6g/cm³
• Refractive Index: 1.661
• CAS DataBase Reference: [(6R,8R,9R)-9-(acetyloxy)-4-amino-8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: [(6R,8R,9R)-9-(acetyloxy)-4-amino-8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate(142102-74-7)
• EPA Substance Registry System: [(6R,8R,9R)-9-(acetyloxy)-4-amino-8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate(142102-74-7)

Safety Data

• Hazardous Substances Data: 142102-74-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
[(6R,8R,9R)-9-(acetyloxy)-4-amino-8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate is used as a pharmaceutical compound for its potential reactivity with biological targets due to the presence of the acetoxy and amino groups. Its unique structure may allow for the development of new drugs targeting specific diseases or conditions.
Used in Organic Synthesis:
In the field of organic synthesis, [(6R,8R,9R)-9-(acetyloxy)-4-amino-8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate can be used as a building block or intermediate for the synthesis of more complex molecules. Its diverse functional groups provide opportunities for further chemical modifications and the creation of novel compounds with specific properties.
Used in Materials Science:
The unique arrangement of atoms and functional groups in [(6R,8R,9R)-9-(acetyloxy)-4-amino-8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate may also find applications in materials science. Its properties could be harnessed to develop new materials with specific characteristics, such as improved mechanical strength, thermal stability, or chemical resistance, depending on the desired application.
Used in Chemical Research:
As a complex molecule with multiple functional groups, [(6R,8R,9R)-9-(acetyloxy)-4-amino-8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-6-yl]methyl benzoate can be used in chemical research to study the effects of its structure on reactivity, stability, and other properties. This knowledge can contribute to the development of new synthetic methods, reaction mechanisms, and understanding of molecular interactions.

Upstream product

• 151215-43-9 1,2-di-O-acetyl-5-O-benzoyl-3-C-cyano-3-O-mesyl-D-ribofuranose 
• 142131-02-0 5-O-benzoyl-3-C-cyano-1,2-O-isopropylidene-3-O-mesyl-α-D-ribofuranose 
• 250588-64-8 Benzoic acid (3aR,5R,6R,6aR)-6-cyano-6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester 
• 142102-71-4 1-(2'-O-acetyl-5'-O-benzoyl-3'-C-cyano-3'-O-mesyl-β-D-ribofuranosyl)thymine 
• 6698-46-0 5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose 

Downstream Products

• 141781-18-2 <1-(β-D-ribofuranosyl)thymine>-3'-spiro-5''-<4''-amino-1'',2''-oxathiole 2'',2''-dioxide> 
• 141781-17-1 2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)pyrimidine 
• 142102-77-0 TSAO-m5C 
• 142102-79-2 TSAO-m3T 
• 142102-80-5 <1-<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>-3-N-ethylthymine>-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) 
• 142102-81-6 <1-<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>-3-N-allylthymine>-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) 
• 142102-82-7 <1-<2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>-3-N-(3-methyl-2-butenyl)thymine>-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) 
• 1039539-95-1 [1-(2'-O-acetyl-5'-O-benzoyl-β-D-ribofuranosyl)-3-N-methylthymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) 

Relevant articles and documents

TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1- [2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides

Several analogues of a new lead for anti-HIV-1 agents [1-[2',5'-bis-O- (tert-butyldimethylsilyl)-β-D-ribofuranosyl]-thymine]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) modified at positions N-3, O- 4 and C-5 of the thymine moiety,