- Preparation method of 4 -tert-butyl phthalonitrile (by machine translation)
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The invention discloses a preparation method of 4 -tert-butylphthalonitrile, and belongs to the technical field of organic synthesis. To the technical scheme, o-xylene and chlorobutane are reacted under the action of catalyst iodine to obtain 4 -tert-butylphthalyl chloride; 4 -tert-butyl phthalic acid is reacted with ammonia solution to obtain 4 -tert-butylphthalamide; 4 -tert-butylphthalamide and dehydrating agent are subjected to dehydration reaction to obtain 4 - 4 - 4 -tert-butylphthalonitrile; and the tert-butylphthalonitrile is obtained through dehydration 4 - 4 . The method has the advantages of mild reaction conditions, high yield, low cost and suitability for industrial production, and is a synthetic method with industrial production value. (by machine translation)
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- Preparation method of 4-tertiary butyl o-phthalaldehyde
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The invention discloses a preparation method of 4-tertiary butyl o-phthalaldehyde, and belongs to the field of organic synthesis. The technical scheme includes that the preparation method includes thesteps: taking the 4-tertiary butyl o-phthalaldehyde as
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Paragraph 0010; 0011; 0012; 0013
(2018/07/30)
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- Metallo-β-lactamase inhibitory activity of phthalic acid derivatives
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4-Butyl-3-methylphthalic acid was recognized as a metallo-β-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.
- Hiraiwa, Yukiko,Morinaka, Akihiro,Fukushima, Takayoshi,Kudo, Toshiaki
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scheme or table
p. 5162 - 5165
(2010/03/24)
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- Synthesis of Tetrakis(4-tert-butylbenzo)porphin and its Metal Complexes
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The condensation of 4-tert-butylphthalimide with sodium and zinc acetates leads to the zinc complex of tetrakis(4-tert-butylbenzo)porphin, which forms the free ligand under the influence of boiling trifluoroacetic acid.A series of metalloporphyrins were obtained from tetrakis(4-tert-butylbenzo)porphin and metal acetates.
- Mamardashvili, N. Zh.,Semeikin, A. S.,Golubchikov, O. A.
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p. 818 - 821
(2007/10/02)
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- Soluble trans-Di-1-alkynyl- and Poly-trans-ethynyl(tetraalkylphthalocyaninato)metal IVB Derivatives
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The hitherto unknown peripheric substituted trans-dihalogeno(tetra-tert-butylphthalocyaninato)metal IVB derivatives 5a,b and 6a,b as well as trans-dichlorogermanium (6c) were converted into the monomeric, soluble trans-di-1-alkynyl(tetra-tert-butylphthalocyaninato)metal IVB compounds 10a - h and trans-di-1-alkynylgermanium compounds 10i - l, respectively, by the reaction with various 1-alkynyl Grignard derivatives 9a - e.The high solubility of all products in organic solvents and the strong ring-current effect of the macrocycle on the axial ligands are remarkable.The formally analogous reaction with the bidentate ethynediyldi-Grignard compound 9f leads to the soluble, acetylene-bridged polymers 12a - c.These are considered as model compounds for a new kind of one-dimensional conductors proposed by us.
- Hanack, Michael,Metz, Josef,Pawlowski, Georg
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p. 2836 - 2853
(2007/10/02)
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