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Maleimide-PEG12-NH, also known as a heterobifunctional crosslinker, is a compound that features an ethylene oxide spacer and is designed for linking amineto sulfhydryl-containing compounds or biomolecules. The maleimide functional group in this molecule reacts with sulfhydryls, while the succinimidyl ester group reacts with amines, providing a versatile tool for various applications in different industries.

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  • 1426151-00-9 Structure
  • Basic information

    1. Product Name: Maleimide-PEG12-NH
    2. Synonyms: 2,5-Dioxopyrrolidin-1-yl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-4-azatritetracontan-43-oate;2,5-Dioxopyrrolidin-1-yl-1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-4-azatritetracontan-43-oate;Maleimide PEG12 succinimidyl ester;Maleimide-PEG12-NH;Maleimide-PEG12-succinimidyl ester
    3. CAS NO:1426151-00-9
    4. Molecular Formula: C38H63N3O19
    5. Molecular Weight: 865.91552
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1426151-00-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: ?20°C
    8. Solubility: N/A
    9. CAS DataBase Reference: Maleimide-PEG12-NH(CAS DataBase Reference)
    10. NIST Chemistry Reference: Maleimide-PEG12-NH(1426151-00-9)
    11. EPA Substance Registry System: Maleimide-PEG12-NH(1426151-00-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1426151-00-9(Hazardous Substances Data)

1426151-00-9 Usage

Uses

Used in Pharmaceutical and Biomedical Applications:
Maleimide-PEG12-NH is used as a crosslinking agent for the conjugation of drugs, targeting moieties, or imaging agents to biomolecules such as proteins, peptides, and antibodies. This allows for the development of targeted drug delivery systems, improved pharmacokinetics, and enhanced therapeutic efficacy.
Used in Bioconjugation and Protein Engineering:
In the field of bioconjugation and protein engineering, Maleimide-PEG12-NH is used as a coupling agent to modify proteins and other biomolecules with specific functional groups. This enables the creation of novel bioconjugates with tailored properties, such as improved stability, solubility, or bioactivity.
Used in Research and Development:
Maleimide-PEG12-NH is utilized as a research tool for the study of protein-protein interactions, enzyme kinetics, and the development of new bioanalytical methods. Its ability to selectively react with specific functional groups allows for the precise manipulation of biomolecules in various experimental setups.
Used in Diagnostics:
In the diagnostics industry, Maleimide-PEG12-NH is employed as a component in the development of immunoassays, biosensors, and other diagnostic tools. Its unique reactivity with sulfhydryl-containing compounds enables the creation of highly specific and sensitive detection systems for various analytes.
Overall, Maleimide-PEG12-NH is a versatile and valuable compound with a wide range of applications in the pharmaceutical, biomedical, research, and diagnostics industries, thanks to its ability to selectively crosslink amineand sulfhydryl-containing compounds or biomolecules.

Check Digit Verification of cas no

The CAS Registry Mumber 1426151-00-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,6,1,5 and 1 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1426151-00:
(9*1)+(8*4)+(7*2)+(6*6)+(5*1)+(4*5)+(3*1)+(2*0)+(1*0)=119
119 % 10 = 9
So 1426151-00-9 is a valid CAS Registry Number.

1426151-00-9Downstream Products

1426151-00-9Relevant articles and documents

Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof

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Page/Page column 141-144; 147; 148, (2019/11/11)

Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.

Preparation method of protein cross-linking agent maleimide-dipolyethylene glycol-acrylic acid succinimide ester

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Paragraph 0041; 0043; 0044, (2019/04/26)

The invention relates to the technical field of organic chemical synthesis, and in particular relates to a preparation method of a protein cross-linking agent maleimide-dipolyethylene glycol-acrylic acid succinimide ester. The method comprises the following steps: step 1, synthesizing 3-maleimide propionyl chloride; step 2, synthesizing maleimide-dipolyethylene glycol-acrylic acid; step 3, synthesizing maleimide-dipolyethylene glycol-acryloyl chloride; and step 4, synthesizing the maleimide-dipolyethylene glycol-acrylic acid succinimide ester. An acyl chloride reagent adopted by the method foran esterification reaction is cheaper than a condensation reagent, the costs can be reduced, the purification is convenient, and removal of by-products of the condensation reagent is avoided; and themethod is suitable for industrialized production.

POLYMER LINKERS AND THEIR USES

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Paragraph 0291-0292, (2019/04/08)

Provided herein are poly-1-hydroxymethylethylene hydroxymethyl formal (PHF)-based drug delivery systems. Also disclosed are methods of making antibodydrug conjugates and methods of treatment using these conjugates.

ANTI-FOLATE RECEPTOR APLHA (FRA) ANTIBODY-DRUG CONJUGATES AND METHODS OF USING THEREOF

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, (2016/06/28)

The present disclosure provides anti-folate receptor alpha (FRA) antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.

ANTI-CD22 ANTIBODY-DRUG CONJUGATES AND METHODS OF USING THEREOF

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Paragraph 0273; 0281, (2016/05/09)

The present disclosure provides anti-CD22 antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.

HYDROPHILIC SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF

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Paragraph 240; 248, (2014/07/08)

The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.

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