144540-71-6

Basic information

• Product Name: (2S, 3aR,7aS)-Benzyl octahydro -1H-indole-2-carboxylate
• Synonyms: (2S, 3aR,7aS)-Benzyl octahydro -1H-indole-2-carboxylate;(2S,3aR,7aS)-Octahydro-1H-indole-2-carboxylic acid phenylmethyl ester;Benzyl (2S,3aR,7aS)-hexahydroindoline-2-carboxylate;(2S, 3aR,7aS)-Benzyl octahydro -2-carboxylate-1H-indole
• CAS NO: 144540-71-6
• Molecular Formula: C₁₆H₂₁NO₂
• Molecular Weight: 259.34344
• Mol File: 144540-71-6.mol

Chemical Properties

• Appearance: /
• Density: 1.103
• CAS DataBase Reference: (2S, 3aR,7aS)-Benzyl octahydro -1H-indole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S, 3aR,7aS)-Benzyl octahydro -1H-indole-2-carboxylate(144540-71-6)
• EPA Substance Registry System: (2S, 3aR,7aS)-Benzyl octahydro -1H-indole-2-carboxylate(144540-71-6)

Safety Data

• Hazardous Substances Data: 144540-71-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2S, 3aR,7aS)-Benzyl octahydro-1H-indole-2-carboxylate is used as a potential pharmaceutical compound for its possible physiological effects. The indole derivative structure suggests that it may have applications in the development of new drugs, particularly given the known biological activities of indole-based compounds.
Used in Chemical Research:
(2S, 3aR,7aS)-Benzyl octahydro-1H-indole-2-carboxylate serves as a subject of study in chemical research, where its reactivity, stereochemistry, and potential interactions with other molecules are explored. This research could lead to a better understanding of its properties and potential applications in various fields, including materials science and synthetic chemistry.

Upstream product

• 68820-12-2 cyclohexyl-N-tosyl aziridine 
• 127-65-1 chloroamine-T 
• 726698-12-0 benzyl-2S,3aR,7aS-octahydroindole carboxylate camphor sulfonate 
• 881637-68-9 (3aR,7aS)-benzyl-perhydroindole-2-carboxylate PTSA salt 
• 1004292-98-1 (2SR,3aRS,7aSR)-octahydro-1H-indole-2-carboxylic acid hydrochloride 
• 100-51-6 benzyl alcohol 

Downstream Products

• 145438-94-4 (2S,3aR,7aS)-octahydroindolecarboxylic acid 
• 98677-37-3 trandolapril benzyl ester 
• 145641-35-6 phenylmethyl-(2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride 

Relevant articles and documents

A population multi-Pulley method for the preparation of intermediates

The invention relates to a method for preparing a trandolapril intermediate in the field of biomedicines, i.e. a method for synthesizing (2S, 3aR, 7aS)-octahydroindole-2-carboxyl benzyl ester. Firstly, cyclohexene and chloramine T are taken as initial raw

PREPARATION OF TRANDOLAPRIL

A process for preparing trandolapril, (2S,3aR,7aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]hexahydro-2-indolinecarboxylic acid, 1-ethyl ester, and intermediates that are useful in the process.

Process for the preparation of intermediates of trandolapril and use thereof for the preparation of trandolapril

A process for the preparation of an intermediate of trandolapril, (2S,3aR,7aS)-perhydroindole-2-carboxylic acid of Formula II is provided. Also provided are processes for preparing trandolapril.

A METHOD FOR THE PREPARATION OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AS KEY INTERMEDIATE IN THE PREPARATION OF TRANDOLAPRIL BY REACTING A CYCLOHEXYL AZIRIDINE WITH A DIALKYL MALONATE

A method for the synthesis of a compound of formula (I) as a mixture of enantiomers, formula (I) (wherein R1 is H or an acid protective group and H+A- indicates an optional acid with which the compound of formula (I) may form an ammonium salt) said method comprising; A) reacting a cyclohexyl aziridine with a dialkyl malonate, whereby to provide a trans-fused 3-alkylcarbonyl-octahydro-indol-2-one; B) decarbonylation at the 3-position, conversion of the ketone of the resulting trans-octahydro-indol-2-one to an optionally protected carboxylic acid group; and C) optionally removing any N-substitution if necessary.