145818-29-7

Basic information

• Product Name: Pyrrolidine, 1-(2,2-diMethyl-1-oxopropyl)-2-[(diphenylphosphino)Methyl]-, (2S)-
• Synonyms: Pyrrolidine, 1-(2,2-diMethyl-1-oxopropyl)-2-[(diphenylphosphino)Methyl]-, (2S)-
• CAS NO: 145818-29-7
• Molecular Formula: C₂₂H₂₈NOP
• Molecular Weight: 353.437581
• Mol File: 145818-29-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrrolidine, 1-(2,2-diMethyl-1-oxopropyl)-2-[(diphenylphosphino)Methyl]-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-(2,2-diMethyl-1-oxopropyl)-2-[(diphenylphosphino)Methyl]-, (2S)-(145818-29-7)
• EPA Substance Registry System: Pyrrolidine, 1-(2,2-diMethyl-1-oxopropyl)-2-[(diphenylphosphino)Methyl]-, (2S)-(145818-29-7)

Safety Data

• Hazardous Substances Data: 145818-29-7(Hazardous Substances Data)

Upstream product

• 15475-27-1 potassium diphenylphosphine 
• 128542-75-6 (S)-2-(bromomethyl)-1-<(tert-butyloxy)carbonyl>pyrrolidine 
• 1079-66-9 chloro-diphenylphosphine 
• 147-85-3 L-proline 
• 135055-75-3 (S)-(-)-N-tert-butoxycarbonyl-2-<(diphenylphosphino)methyl>pyrrolidine 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 60261-46-3 (2S)-2-[(diphenylphosphino)methyl]pyrrolidine 
• 3282-30-2 pivaloyl chloride 
• 86661-32-7 (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Proline-based P,O ligand/iridium complexes as highly selective catalysts: Asymmetric hydrogenation of trisubstituted alkenes

P,O joins the mix: P,O ligands (L1) form efficient iridium catalysts for the asymmetric hydrogenation of olefins. The proline-derived ligands lead to high enantioselectivities with several classes of alkenes, most notably with α,β-unsaturated carboxylic e

Unsymmetrical terdentate phosphorus-nitrogen-nitrogen (PNN) ligands: Effect of the M/L ratio and the pendant group on stereoselectivity

Twelve novel, unsymmetrical terdentate pyrrolidine-based phosphorus-nitrogen ligands were prepared. These ligands promoted very high catalytic activity in the palladium-catalysed allylic substitution reactions of 1,3-diphenylpropenyl acetate with malonate

An efficient procedure for the preparation of (E)-α-alkylidenecycloalkanones mediated by a CeCl3·7H2O-NaI system. Novel methodology for the synthesis of (S)-(-)-pulegone

2-Alkylidenecycloalkanones are powerful synthons used as the key intermediates in many important syntheses. Because of their potential, a general method of preparation from readily available starting materials, under very mild conditions, was considered to be worthwhile. Cerium(III) chloride heptahydrate in combination with sodium iodide in refluxing acetonitrile promotes a regio- and stereoselective β-elimination reaction to (E)-2-alkylidenecycloalkanones in 2-(1-hydroxyalkyl)cycloalkanones. The synthetic value of the present procedure is demonstrated by the synthesis of monoterpene (S)-(-)-pulegone (8) in its optically active form.

Catalytic enantioselective conjugate addition of Grignard reagents to cyclic α,β-unsaturated carbonyl compounds

A catalytic asymmetric conjugate addition reaction of organocopper reagents, generated from copper salt, a chiral phosphine, and Grignard reagent, with cyclohexenone is highly dependent on the counter anion of copper species, solvents, Grignard reagents,