(2S)-1-Pivaloyl-2-(diphenylphosphinomethyl)pyrrolidine

Base Information

Chemical Name:(2S)-1-Pivaloyl-2-(diphenylphosphinomethyl)pyrrolidine
CAS No.:145818-29-7
Molecular Formula:C22H28NOP
Molecular Weight:353.444
Hs Code.:
DSSTox Substance ID:DTXSID201136927
Nikkaji Number:J1.070.378F
Mol file:145818-29-7.mol

Synonyms:DTXSID201136927;(2S)-1-Pivaloyl-2-(diphenylphosphinomethyl)pyrrolidine;1-[(2S)-2-[(Diphenylphosphino)methyl]-1-pyrrolidinyl]-2,2-dimethyl-1-propanone;145818-29-7

Suppliers and Price of (2S)-1-Pivaloyl-2-(diphenylphosphinomethyl)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2S)-1-Pivaloyl-2-(diphenylphosphinomethyl)pyrrolidine

Chemical Property:

PSA：33.90000
LogP:4.09430
XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:5
Exact Mass:353.190851514
Heavy Atom Count:25
Complexity:414

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C(=O)N1CCCC1CP(C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES:CC(C)(C)C(=O)N1CCC[C@H]1CP(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of (2S)-1-Pivaloyl-2-(diphenylphosphinomethyl)pyrrolidine

There total 9 articles about (2S)-1-Pivaloyl-2-(diphenylphosphinomethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 60261-46-3
(2S)-2-[(diphenylphosphino)methyl]pyrrolidine

: 3282-30-2
pivaloyl chloride

: 145818-29-7
(S)-(-)-N-(2,2-dimethylpropionyl)-2-<(diphenylphosphino)methyl>pyrrolidine

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jo026418s

Reference yield:

: 135055-75-3
(S)-(-)-N-tert-butoxycarbonyl-2-<(diphenylphosphino)methyl>pyrrolidine

: 145818-29-7
(S)-(-)-N-(2,2-dimethylpropionyl)-2-<(diphenylphosphino)methyl>pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 2 h / 0 °C

1.2: 90 percent / aq. ammonia / CHCl₃ / 0.17 h / 20 °C

2.1: 96 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo026418s

Reference yield:

: 86661-32-7
(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate

: 145818-29-7
(S)-(-)-N-(2,2-dimethylpropionyl)-2-<(diphenylphosphino)methyl>pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium / dioxane / 15 h / Heating

1.2: 93 percent / dioxane; tetrahydrofuran / 19 h / 20 °C

2.1: trifluoroacetic acid / 2 h / 0 °C

2.2: 90 percent / aq. ammonia / CHCl₃ / 0.17 h / 20 °C

3.1: 96 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With sodium; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo026418s