cas 14617-06-2, 4-(2,4-dimethoxyphenyl)-4-oxo-butanoic acid

Articles about 14617-06-2Total 7 be found

TMSCl-Catalyzed Electrophilic Thiocyano Oxyfunctionalization of Alkenes Using N-Thiocyano-dibenzenesulfonimide
Numerous electrophilic thiocyano oxyfunctionalization reactions of alkenes have been achieved using N-thiocyano-dibenzenesulfonimide, which is a new electrophilic thiocyanation reagent and could be easily prepared in two steps from dibenzenesulfonimide. T
Ye, Ai-Hui,Zhang, Ye,Xie, Yu-Yang,Luo, Hui-Yun,Dong, Jia-Wei,Liu, Xiao-Dong,Song, Xu-Feng,Ding, Tongmei,Chen, Zhi-Min
p. 5106 - 5110
(2019)
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Studies on Antibiotics Active against Resistant Bacteria. Total Synthesis of MRSA-Active Tetarimycin A and Its Analogues
Making use of the Hauser-Kraus annulation as a key step, the first total synthesis of tetarimycin A has been accomplished in a highly convergent and operationally simple manner. Preliminary SAR not only validated that tetarimycin A exhibited potent activi
Huang, Jing-Kai,Yang Lauderdale, Tsai-Ling,Shia, Kak-Shan
supporting information
p. 4248 - 4251
(2015/09/15)

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors
The involvement of μ-calpain in neurological disorders, such as stroke and Alzheimer's disease has attracted considerable interest in the use of calpain inhibitors as therapeutic agents. 4-Aryl-4-oxobutanoic acid amide derivatives 4 were designed as acyclic variants of μ-calpain inhibitory chromone and quinolinone derivatives. Of the compounds synthesized, 4c-2, which possesses a 2-methoxymethoxy group at the phenyl ring and a primary amide at the warhead region most potently inhibited μ-calpain (IC50 = 0.34 μM). Our findings suggest that the 4-aryl-4-oxobutanoic acid amide derivatives should be considered as a new family of μ-calpain inhibitors.
Zhang, Yong,Jung, Seo Yoon,Jin, Changbae,Kim, Nam Doo,Gong, Ping,Lee, Yong Sup
scheme or table
p. 502 - 507
(2011/02/28)

A simple synthesis of α-methyl-γ-keto acids
The reaction of the anion derived from α-marpholinonitriles with methyl acrylate in excess of NaH in DMF gives γ-keto acids in high yield. This process is highly convenient for the synthesis of various α-substituted-γ-keto acids, which can be easily converted to naturally occurring α-substituted -γ-lactones.
Pawar,Waghmare,Lokhande
p. 2549 - 2551
(2007/10/03)

Process for the production of cyclic sulfonium salts
A process for the production of a 5-7 membered ring cyclic sulfonium salt compound, including a 5-7 membered ring cyclic sulfonium salt compound having a non-nucleophilic anion, is described. Members of the latter group are potentially useful as initiators for cationic polymerizations. The process comprises reacting a 1.4-, 1.5-, or 1.6-diol compound or a 5-7 membered ring cyclic ether compound with a mercapto compound and a strong protonic acid yielding the cyclic sulfonium salt compound. Some compounds described are also novel compounds per se.
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(2008/06/13)

Syntheses of Tetrahydronaphthalenes. Part II
Syntheses utilizing the cyclodehydration method to prepare novel tetrahydronaphthalenes substituted with functional groups at each position of the aromatic ring and various alkyl groups at the 1-position of the non-aromatic ring are described.
Parlow, John J.
p. 3297 - 3314
(2007/10/02)