146629-34-7 Usage
Uses
Used in Antiviral Applications:
5-(TriMethylstannyl)-2'-deoxyuridine is used as a substrate for herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) derived from HSV-1 TK gene-transfected murine mammary carcinoma FM3A cells. This application is based on the compound's ability to interact with the viral enzyme, potentially leading to the development of antiviral therapies targeting HSV-1.
Used in Anticancer Applications:
5-(TriMethylstannyl)-2'-deoxyuridine is also used as a substrate for human platelet thymidine (dThd) phosphorylase. This application is relevant to the development of anticancer therapies, as the compound may be utilized to target specific enzymes involved in cancer cell metabolism and proliferation.
Check Digit Verification of cas no
The CAS Registry Mumber 146629-34-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,6,2 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146629-34:
(8*1)+(7*4)+(6*6)+(5*6)+(4*2)+(3*9)+(2*3)+(1*4)=147
147 % 10 = 7
So 146629-34-7 is a valid CAS Registry Number.
146629-34-7Relevant articles and documents
Synthesis of 5-radiohalo-2'-deoxyuridine
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, (2008/06/13)
Method of synthesizing 5-radio-halogenated-2'-deoxyuridine from 5-trimethylstannyl-2'-deoxyuridine is described. The method consists of the steps of mixing 5-trimethylstannyl-2'-deoxyuridine with an aqueous solution consisting of a radiohalide and NaOH to form a first mixture, adding H2 O2 /CH3 COOH to the first mixture to form a second mixture, sonicating the second mixture, evaporating the solvent from the second mixture to form a residue, reconstituting the residue, filtering the residue; and then purifying the filtered residue such that at least one of a radiohalogenated nucleoside and nucleotide is obtained. A kit consisting of the components required for the above synthesis is also described.
