148507-73-7

Basic information

• Product Name: 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)
• Synonyms: 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (2S)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) (salt) (9CI);2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)
• CAS NO: 148507-73-7
• Molecular Formula: C₄H₆O₆*C₁₅H₂₅NO₃
• Molecular Weight: 417.46
• Mol File: 148507-73-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)(148507-73-7)
• EPA Substance Registry System: 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)(148507-73-7)

Safety Data

• Hazardous Substances Data: 148507-73-7(Hazardous Substances Data)

Upstream product

• 51384-51-1 (RS)-metoprolol 
• 87-69-4 tartaric acid 
• 56718-71-9 4-(2-methoxyethyl)phenol 

Downstream Products

• 138768-62-4 N-nitrosometoprolol 
• 1251957-60-4 C₁₅H₂₄⁽¹²⁵⁾INO₃ 

Relevant articles and documents

PROCESS FOR MANUFACTURE OF METOPROLOL AND SALTS THEREOF

Metoprolol manufacturing process with optimized reaction temperatures and reactant molar ratios, to avoid the manufacture of excessive epoxide intermediates, thus avoiding the need for purification of epoxide intermediates, thus achieving higher yields and higher-purity product than that seen in the prior art teachings.

Metoprolol manufacturing process

Metoprolol manufacturing process with optimized reaction temperatures and reactant molar ratios, to avoid the manufacture of excessive epoxide intermediates, thus avoiding the need for purification of epoxide intermediates, thus achieving higher yields and higher-purity product than that seen in the prior art teachings.

Controlled release formulation

A controlled release pharmaceutical formulation is provided which releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight of a pH dependent polymer which is a salt of alginic acid, such as sodium alginate, up to about 35% by weight of a pH-independent hydrocarbon gelling agent having a viscosity of up to about 100,000 centipoises in 2% solution at 20° C., binder and excipients.