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Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaAmine, 3,4-diMethoxy-N-Methylis a complex organic compound with a unique bicyclic structure and various functional groups. It is characterized by its bicyclic framework, methoxy substitutions, and a nitrogen-containing side chain. Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methylis known for its presence as an impurity in Ivabradine, a medication used for certain heart conditions.

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  • Bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine, 3,4-dimethoxy-N-methyl-

    Cas No: 148870-56-8

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  • 148870-56-8 Structure
  • Basic information

    1. Product Name: Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-
    2. Synonyms: Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-;1-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-N-methylmethanamine
    3. CAS NO:148870-56-8
    4. Molecular Formula: C12H17NO2
    5. Molecular Weight: 207.26888
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 148870-56-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 305.284°C at 760 mmHg
    3. Flash Point: 124.143°C
    4. Appearance: /
    5. Density: 1.062g/cm3
    6. Vapor Pressure: 0.001mmHg at 25°C
    7. Refractive Index: 1.528
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 9.94±0.10(Predicted)
    11. CAS DataBase Reference: Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-(CAS DataBase Reference)
    12. NIST Chemistry Reference: Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-(148870-56-8)
    13. EPA Substance Registry System: Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-(148870-56-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 148870-56-8(Hazardous Substances Data)

148870-56-8 Usage

Uses

Used in Pharmaceutical Industry:
Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaAmine, 3,4-diMethoxy-N-Methylis used as an impurity in the production of Ivabradine (I940500) for its antianginal properties. It plays a role in the development and formulation of heart medications, specifically those aimed at treating angina and related cardiovascular conditions.
As an impurity in Ivabradine, this compound may also contribute to the overall efficacy and safety profile of the drug. Understanding its presence and effects can help in optimizing the drug's performance and minimizing potential side effects. Additionally, further research into its properties and interactions may reveal new therapeutic applications or opportunities for its use in other areas of the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 148870-56-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,8,7 and 0 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 148870-56:
(8*1)+(7*4)+(6*8)+(5*8)+(4*7)+(3*0)+(2*5)+(1*6)=168
168 % 10 = 8
So 148870-56-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO2/c1-13-7-9-4-8-5-11(14-2)12(15-3)6-10(8)9/h5-6,9,13H,4,7H2,1-3H3

148870-56-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name ({3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl)(methyl)amine

1.2 Other means of identification

Product number -
Other names (R,S)-1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methyl-methanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148870-56-8 SDS

148870-56-8Relevant articles and documents

AN IMPROVED PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

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Paragraph 15; 16, (2019/11/12)

: Disclosed herein is an improved process for the preparation of Ivabradine and pharmaceutically acceptable salts thereof. The invention more particularly disclosesthe synthesis of key intermediates viz.,(S)-N-[(4,5-dimethoxybenzocydobut-l-yl)-methyl]-N- (methyl)amine hydrochloride of Formula-II and 3-(3-Iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzapin-2-one of Formula-III, and its use in industrial synthesis of Ivabradine and pharmaceutically acceptable salts thereof.

(1 S) - 4, 5 - dimethoxy - 1 - [(methylamino) methyl] benzocyclobutane preparation of hydrochloride salts of method

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Paragraph 0109; 0114; 0115, (2018/04/02)

The invention provides a preparation method of (1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride, which specially comprises the following step: carrying out reduction and salting-out on 4,5-dimethoxybenzocyclobutyl-1-methyl formamide in an inert solvent to finally obtain the (1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride (I). The reaction is simple to operate, has the advantages of mild reaction conditions, clean and accessible raw/auxiliary materials, low overall cost, high chemical and enantiomer purity and the like, and therefore, is suitable for industrial production.

PROCESS FOR THE SYNTHESIS OF 3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

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, (2014/06/24)

Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

PROCESS FOR THE SYNTHESIS OF (2E)-3-(3,4-DIMETHOXYPHENYL)PROP-2-ENENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

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, (2014/05/20)

Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

PROCESS FOR THE SYNTHESIS OF 3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

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Paragraph 0058-0059, (2014/05/07)

Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

PROCESS FOR PREPARATION OF IVABRADINE

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Page/Page column 13-14, (2010/07/09)

The present invention describes a new process for optical resolution of [N-[[3,4- dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine] which is an intermediate in the preparation of ivabradine.

(Benzocycloalkyl) alkylamines

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, (2008/06/13)

The compounds are 3-[ (benzocycloalkyl)alkyl amino alkyl] -1,3,4,5-te trahydro 2H- 3-benzazepin-2 ones useful in cardiovascular field.A compound disclosed is (R,S)-7,8-dimethoxy-3-{3-{N-[(4,5-dimethoxybenzocyclobut-1-yl) methyl]-N-methyl amino}propyl}-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one.

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