150878-36-7Relevant articles and documents
Chiral resolution process
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, (2008/06/13)
A chiral resolution process is described for the purification of a substituted chiral quinazoline, by salt formation with a resolving agent, followed by crystallization.
Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4- dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
Tucker,Lyle,Wiscount,Britcher,Young,Sanders,Lumma,Goldman,O'Brien,Ball,Homnick,Schleif,Emini,Huff,Anderson
, p. 2437 - 2444 (2007/10/02)
As part of an ongoing effort to prepare novel non-nucleoside inhibitors of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT), a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin- 2(1H)-ones 4aa-1 has been prepared
Synthesis of a New Generation Reverse Transcriptase Inhibitor via the BCl3/GaCl3-induced Condensation of Anilines with Nitriles (Sugasawa Reaction)
Houpis, Ioannis N.,Molina, Audrey,Douglas, Alan W.,Xavier, Lyndon,Lynch, Joseph,et al.
, p. 6811 - 6814 (2007/10/02)
The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.
New quinazolines as inhibitors of HIV reverse transcriptase
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, (2008/06/13)
Compounds having a quinazolin-2-one nucleus with a substituted alkynyl or substituted alkenyl at the 4-position are described. These compounds are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or