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150878-36-7

6-Chloro-4-cyclopropyl-1H-quinazolin-2-one is a chemical compound with the molecular formula C11H8ClN3O, belonging to the class of quinazolinone derivatives. Characterized by its cyclopropyl and chloro functional groups, this compound has been studied for its potential pharmaceutical applications and has been found to exhibit interesting biological activities. Its unique structure and properties make it a valuable target for synthetic strategies and chemical transformations, holding promise as a versatile and valuable chemical compound with potential utility in the pharmaceutical industry.

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  • 150878-36-7 Structure

  • Basic information

    1. Product Name: 6-Chloro-4-cyclopropyl-1H-quinazolin-2-one
    2. Synonyms: 6-Chloro-4-cyclopropyl-1H-quinazolin-2-one;6-chloro-4-cyclopropylquinazolin-2(1H)-one;6-Chloro-4-cyclopropyl-1,2-dihydro-2-oxoquinazoline;6-Chloro-4-cyclopropylquinazolin-2(1H)-one 95+%;6-Chloro-4-cyclopropyl-1H-quinazolin-2-one C11H9ClN2O 220.658;6-Chloro-4-cyclopropyl-2(1H)-quinazolinone
    3. CAS NO:150878-36-7
    4. Molecular Formula: C11H9ClN2O
    5. Molecular Weight: 220.658
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 150878-36-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.57
    6. Refractive Index: 1.751
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-Chloro-4-cyclopropyl-1H-quinazolin-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-Chloro-4-cyclopropyl-1H-quinazolin-2-one(150878-36-7)
    11. EPA Substance Registry System: 6-Chloro-4-cyclopropyl-1H-quinazolin-2-one(150878-36-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 150878-36-7(Hazardous Substances Data)

150878-36-7 Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-4-cyclopropyl-1H-quinazolin-2-one is used as a pharmaceutical candidate for the development of new drugs for various medical conditions due to its interesting biological activities and potential applications in medicinal chemistry research.
Used in Medicinal Chemistry Research:
6-Chloro-4-cyclopropyl-1H-quinazolin-2-one is used as a subject of interest in medicinal chemistry research to explore its potential applications and to develop synthetic strategies and chemical transformations for its utilization in drug development.
Used in Drug Development:
6-Chloro-4-cyclopropyl-1H-quinazolin-2-one is used as a valuable target in drug development for its unique structure and properties, which contribute to its potential utility in creating new and effective pharmaceuticals for treating various medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 150878-36-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,8,7 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 150878-36:
(8*1)+(7*5)+(6*0)+(5*8)+(4*7)+(3*8)+(2*3)+(1*6)=147
147 % 10 = 7
So 150878-36-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H9ClN2O/c12-7-3-4-9-8(5-7)10(6-1-2-6)14-11(15)13-9/h3-6H,1-2H2,(H,13,14,15)

150878-36-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Chloro-4-cyclopropylquinazolin-2(1H)-one

1.2 Other means of identification

Product number -
Other names 6-Chloro-4-cyclopropyl-1H-quinazolin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:150878-36-7 SDS

150878-36-7Relevant articles and documents

Chiral resolution process

-

, (2008/06/13)

A chiral resolution process is described for the purification of a substituted chiral quinazoline, by salt formation with a resolving agent, followed by crystallization.

Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4- dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Tucker,Lyle,Wiscount,Britcher,Young,Sanders,Lumma,Goldman,O'Brien,Ball,Homnick,Schleif,Emini,Huff,Anderson

, p. 2437 - 2444 (2007/10/02)

As part of an ongoing effort to prepare novel non-nucleoside inhibitors of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT), a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin- 2(1H)-ones 4aa-1 has been prepared

Synthesis of a New Generation Reverse Transcriptase Inhibitor via the BCl3/GaCl3-induced Condensation of Anilines with Nitriles (Sugasawa Reaction)

Houpis, Ioannis N.,Molina, Audrey,Douglas, Alan W.,Xavier, Lyndon,Lynch, Joseph,et al.

, p. 6811 - 6814 (2007/10/02)

The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.

New quinazolines as inhibitors of HIV reverse transcriptase

-

, (2008/06/13)

Compounds having a quinazolin-2-one nucleus with a substituted alkynyl or substituted alkenyl at the 4-position are described. These compounds are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or

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