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152-47-6

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Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein
Through high-throughput screening of 200000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small molecule inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chemical genetic approach, we utilized an NSA based chemical probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.
Liao, Daohong,Sun, Liming,Liu, Weilong,He, Sudan,Wang, Xiaodong,Lei, Xiaoguang
p. 333 - 337
(2014/03/21)

Sulfonamide molecular crystals: Structure, sublimation thermodynamic characteristics, molecular packing, hydrogen bonds networks
The crystal structures of ten sulfonamides have been determined by X-ray diffraction. On the basis of our previous data, the obtained results and literature data crystal properties including molecular conformational states, packing architecture, and hydrogen bond networks were comparatively analyzed using graph set notations. Conformational flexibility of the bridge connecting two phenyl rings was studied. It was found out that the most frequently occurring graphs for compounds with a single hydrogen bond are infinite chains with four atoms included. The molecular packing architecture of the selected crystals may be conditionally divided into three different groups. The idea underlying such classification is the difference in structure and composition of molecular layers that can be singled out for most packings. The influence of various molecular fragments on crystal lattice energy was analyzed. A correlation between melting points and fragmental molecular interactions in the crystal lattices was obtained. The thermodynamic aspects of the sulfonamide sublimation were studied by determining the temperature dependence of vapor pressure using the transpiration method. A correlation between the Gibbs energy of the sublimation process and the melting points was found. Besides, a regression equation was derived to describe the correlation between the sublimation entropy terms and crystal density data calculated from X-ray diffraction results.
Perlovich, German L.,Ryzhakov, Alex M.,Tkachev, Valery V.,Hansen, Lars Kr.,Raevsky, Oleg A.
p. 4002 - 4016
(2013/09/24)

Chemical Properties

Appearance/Colour :White or slightly yellow crystal powder
Melting Point: 174~178 °C
Boiling Point: 488.6 °C at 760 mmHg
Flash Point:249.3 °C
Density: 1.465 g/cm³
Solubility:DMSO (Slightly), Methanol (Slightly, heated)
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
Vapor Pressure: 1.07E-09mmHg at 25°C
Refractive Index: 1.646
PKA: pKa 6.20(H2O t = 25.0±0.5 I = 0.2) (Uncertain)
Merck: 14,8910
PSA: 115.58000
LogP: 2.60320

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Chemical Properties

Appearance/Colour :White or slightly yellow crystal powder

Melting Point: 174~178 °C

Boiling Point: 488.6 °C at 760 mmHg

Flash Point:249.3 °C

Density: 1.465 g/cm³

Solubility:DMSO (Slightly), Methanol (Slightly, heated)

Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature

Vapor Pressure: 1.07E-09mmHg at 25°C

Refractive Index: 1.646

PKA: pKa 6.20(H2O t = 25.0±0.5 I = 0.2) (Uncertain)

Merck: 14,8910

PSA: 115.58000

LogP: 2.60320

Global suppliers and manufacturers of 152-47-6total 114 suppliers on LookChem

Article Database

152-47-6

Articles about 152-47-6Total 2 be found

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Chemical Properties

Appearance/Colour :White or slightly yellow crystal powder

Melting Point: 174~178 °C

Boiling Point: 488.6 °C at 760 mmHg

Flash Point:249.3 °C

Density: 1.465 g/cm3

Solubility:DMSO (Slightly), Methanol (Slightly, heated)

Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature

Vapor Pressure: 1.07E-09mmHg at 25°C

Refractive Index: 1.646

PKA: pKa 6.20(H2O t = 25.0±0.5 I = 0.2) (Uncertain)

Merck: 14,8910

PSA: 115.58000

LogP: 2.60320

Global suppliers and manufacturers of 152-47-6total 114 suppliers on LookChem

Density: 1.465 g/cm³