15409-48-0

Basic information

• Product Name: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
• Synonyms: VITAS-BB TBB000142;CHEMBRDG-BB 4400208;ART-CHEM-BB B000126;5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID;AKOS B000126;5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid(SALTDATA: FREE)
• CAS NO: 15409-48-0
• Molecular Formula: C₁₇H₁₄N₂O₂
• Molecular Weight: 278.31
• Mol File: 15409-48-0.mol

Chemical Properties

• Melting Point: 196°C
• Boiling Point: 447.5°C at 760 mmHg
• Flash Point: 224.4°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 8.59E-09mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(15409-48-0)
• EPA Substance Registry System: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(15409-48-0)

Safety Data

• Hazardous Substances Data: 15409-48-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its potential pharmacological and biological activities. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Chemical Synthesis:
In the chemical industry, 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID is used as a building block for the synthesis of other organic compounds and materials. Its versatile chemical structure enables the creation of a wide range of products with diverse applications.
Used in Drug Design and Medicinal Chemistry:
5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID is utilized as a structural component in drug design and medicinal chemistry. Its incorporation into drug molecules can enhance their pharmacological properties, such as potency, selectivity, and bioavailability.
Used in Chemical Reagent Formulation:
As a carboxylic acid, 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID can be used as a reagent in various chemical reactions, such as esterification, amidation, and other condensation reactions. This makes it a valuable component in the formulation of chemical reagents for research and industrial applications.
Used in Material Science:
The unique structure of 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID also makes it suitable for applications in material science. It can be used in the development of new materials with specific properties, such as conductivity, stability, or responsiveness to external stimuli.

InChI:InChI=1/C17H14N2O2/c1-12-15(17(20)21)16(13-8-4-2-5-9-13)18-19(12)14-10-6-3-7-11-14/h2-11H,1H3,(H,20,21)

Upstream product

• 7189-04-0 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 100-63-0 phenylhydrazine 
• 100-52-7 benzaldehyde 
• 620-80-4 ethyl 2-benzylidene acetoacetate 
• 854901-03-4 5-methyl-1,3-diphenyl-1H-pyrazole-4-carbonitrile 
• 588-64-7 benzaldehyde phenylhydrazone 
• 854699-23-3 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid amide 

Downstream Products

• 7188-89-8 5-methyl-1,3-diphenyl-1H-pyrazole 
• 125103-49-3 (5-Methyl-1,3-diphenyl-1H-pyrazol-4-yl)-morpholin-4-yl-methanone 
• 125103-43-7 N-benzyl-N,5-dimethyl-1,3-diphenyl-1H-pyrazole-4-carboxamide 
• 125103-46-0 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid dipropylamide 
• 125103-45-9 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid diisopropylamide 
• 125103-47-1 N-benzyl-5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxamide 
• 125103-48-2 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid (3-methyl-butyl)-amide 
• 125103-50-6 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid butylamide 
• 125103-42-6 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid (2-hydroxy-ethyl)-amide 
• 125103-44-8 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid tert-butylamide 
• 124-38-9 carbon dioxide 
• 857058-17-4 1,3-diphenyl-5-methylpyrazole-4-carboxylic chloride 

Relevant articles and documents

A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation

Abstract: A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, 1H and 13C NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity.

Novel pyrazole integrated 1,3,4-oxadiazoles: Synthesis, characterization and antimicrobial evaluation

A novel series of 2-(5-methyl-1,3-diphenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4- oxadiazoles 7(a-m) were synthesized either by cyclization of N′-benzoyl-5-methyl-1,3-diphenyl-1H-pyrazole-4-carbohydrazide 4a using POCl3 at 120 C or by oxidative cycli

The first chemoselective tandem acylation of the Blaise reaction intermediate: A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are

NEUROKININ-3 RECEPTOR MODULATORS: DIARYL PYRAZOLE DERIVATIVES

The invention relates to compounds of general Formula (I) wherein the variables are as defined herein. Pharmaceutical compositions comprising compounds of general Formula (I), and methods for treating patients suffering from a disorder responsive to neuro