15789-04-5Relevant articles and documents
Directed ortho and Remote Metalation–Suzuki–Miyaura Cross Coupling Route to Azafluorenol Core Liquid Crystals
Lai, Ping-Shan,Jansen-Van Vuuren, Ross D.,Lemieux, Robert P.,Snieckus, Victor
, p. 17543 - 17549 (2021/12/13)
Two new smectic C* mesogens containing a hexyloxy side chain and an azafluorenone (3a) or azafluorenol (3b) core were synthesized using a combined directed ortho metalation-directed remote metalation–Suzuki–Miyaura cross-coupling strategy. 3b was formed i
Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics
Aujay, Monette,Das, Dipendu,Gavrilyuk, Julia,Hammond, Mikhail,Lu, Yong,Lyssikatos, Joseph,Nicolaou, K. C.,Pitsinos, Emmanuel N.,Rout, Subhrajit,Sandoval, Joseph,Schammel, Alexander
, (2020/02/13)
The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimycins A-
Iridium(I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes: Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters
Fernández, David F.,Gulías, Moisés,Mascare?as, José L.,López, Fernando
, p. 9541 - 9545 (2017/08/01)
A catalytic, versatile and atom-economical C?H functionalization process that provides a wide variety of cyclic systems featuring methyl-substituted quaternary stereocenters is described. The method relies on the use of a cationic IrI–bisphosph
Photolytic degradation of N,N-diethyl-m-toluamide in ice and water: Implications in its environmental fate
Calza,Medana,Sarro,Baiocchi,Minero
, p. 99 - 104 (2013/10/01)
The photochemical transformation of N,N-diethyl-m-toluamide (DEET), one of the most widespread and efficient mosquito repellents, has been investigated. Initially, photoinduced DEET degradation was investigated in liquid samples, at 20 C and 0 C, and in ice (-15 C), aimed to simulate all possible photoinduced processes occurring in water and in cold environments. Under UV-illumination, DEET degradation was more efficient in ice than in water. The evaluation of transformation products (TPs) formed during the photolysis in solution and in ice evidences mostly the same degradation products, but with different concentration ratio and some peculiar differences. An hypothesis about what kind of processes may play a role is reported. In solution, the oxidative process mostly involved were (poly)hydroxylation or oxidation of the hydroxyl groups, while in ice N-dealkylation and monohydroxylation prevail. Finally, DEET and its TPs were searched out in snow and river water in wintertime.
Synthesis and SAR of selective small molecule neuropeptide y Y2 receptor antagonists
Mittapalli, Gopi Kumar,Vellucci, Danielle,Yang, Jun,Toussaint, Marion,Brothers, Shaun P.,Wahlestedt, Claes,Roberts, Edward
scheme or table, p. 3916 - 3920 (2012/07/03)
Highly potent and selective small molecule neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit molecule N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 16 (CYM 9484) and 54 (CYM 9552) with IC50 values of 19 nM and 12 nM respectively.
Regiocontrolled rearrangement of isobenzofurans
Egan, Ben A.,Paradowski, Michael,Thomas, Lynne H.,Marquez, Rodolfo
, p. 2086 - 2089 (2011/06/25)
Regioselective alkylation and oxidative rearrangement of isobenzofurans has been achieved to generate substituted 4,8- ihydroxyisochromanones in good yields and with complete regiocontrol.
PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS
-
Page/Page column 46, (2011/05/08)
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein R1, R2, R3, and L, A, and Ra are defined herein.
The cobalt way to angucyclinones: Asymmetric total synthesis of the antibiotics (+)-rubiginone B2, (-)-tetrangomycin, and ( - ) -8- O-Methyltetrangomycin
Kesenheimer, Christian,Kalogerakis, Aris,Meissner, Anja,Groth, Ulrich
experimental part, p. 8805 - 8821 (2010/10/21)
A cobalt(I)-mediated convergent and asymmetric total synthesis of angucyclinones with an aromatic B ring has been developed. In the course of our research, we synthesized three naturally occurring anguclinone derivatives, namely, (+)-rubiginone B2/s
Enantioselective synthesis of the dimeric pyranonaphthoquinone core of the cardinalins using a late-stage homocoupling strategy
Sperry, Jonathan,Gibson, Jennifer S.,Sejberg, Jimmy J. P.,Brimble, Margaret A.
supporting information; experimental part, p. 4261 - 4270 (2009/02/07)
The enantioselective synthesis of a dimeric pyranonaphthoquinone closely related to the cardinalins is described. Whilst attempts to effect a double Hauser-Kraus annulation of enone 5 were unsuccessful using both bis-phthalide 4 and bis-sulfone 21, a sing
1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF
-
Page/Page column 44-45, (2008/06/13)
Compounds of general formula (I) wherein D, E, R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
