15846-25-0

Basic information

• Product Name: 3-aminocrotonamide
• Synonyms: 3-Aminocrotonamide,85%,tech.;2-Butenamide, 3-amino-;Einecs 239-956-0;3-AMino-but-2-enaMide;(Z)-3-aminobut-2-enamide
• CAS NO: 15846-25-0
• Molecular Formula: C₄H₈N₂O
• Molecular Weight: 100.12
• EINECS: 239-956-0
• Mol File: 15846-25-0.mol

Chemical Properties

• Melting Point: 100-101 °C
• Boiling Point: 278.5°C at 760 mmHg
• Flash Point: 122.3°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0.00424mmHg at 25°C
• Refractive Index: 1.508
• PKA: 15.42±0.50(Predicted)
• CAS DataBase Reference: 3-aminocrotonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-aminocrotonamide(15846-25-0)
• EPA Substance Registry System: 3-aminocrotonamide(15846-25-0)

Safety Data

• Hazardous Substances Data: 15846-25-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Aminocrotonamide is used as a building block for the synthesis of various drugs, contributing to the development of new pharmaceuticals.
Used in Metal Complexes:
3-Aminocrotonamide is used as a ligand in metal complexes, playing a role in the formation and stabilization of these complexes.
Used in Organic Reactions:
3-Aminocrotonamide is used as a catalyst in organic reactions, facilitating and enhancing the efficiency of certain chemical processes.
Used in Research and Development:
3-Aminocrotonamide is used in research for its potential therapeutic properties, with ongoing investigations into its applications in medicine.

InChI:InChI=1/C4H8N2O/c1-3(5)2-4(6)7/h2H,5H2,1H3,(H2,6,7)/b3-2-

Upstream product

• 5977-14-0 acetoacetamido 
• 141-97-9 ethyl acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 1360588-21-1 6-amino-4-methyl-5-[4-(methylphenyl)diazenyl]-2,2-diphenyl-3H-1,3,2λ⁴-oxazaborine 
• 86454-07-1 3,4-dihydro-6-methyl-4-oxo-2-pyrimidinepropanoic acid 
• 6622-92-0 2,6-dimethyl-1H-pyrimidin-4-one 
• 56951-00-9 ethyl 1,6-dihydro-2-hydroxy-4-methyl-6-oxo-3-pyridinecarboxylate 
• 143755-55-9 5-Carbamoyl-2,6-dimethyl-4-phenyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 86454-11-7 2-(3,4-dihydro-6-methyl-4-oxopyrimidin-2-yl)benzoic acid 
• 83726-89-0 6-methyl-2-(2'-methylthiazol-4'-yl)pyrimidin-4(3H)-one 
• 59341-68-3 6-methyl-2-(pyridin-4'-yl)pyrimidin-4(3H)-one 
• 55417-80-6 6-methyl-2-(pyridin-2'-yl)pyrimidin-4(3H)-one 

Relevant articles and documents

Synthesis and Characterization of New Boron Compounds Using Reaction of Diazonium Tetraphenylborate with Enaminoamides

A family of oxazaborines, diazaborinones, triazaborines, and triazaborinones was prepared by reaction of polarized ethylenes, such as β-enaminoamides, with 4-methylbenzenediazo-nium tetraphenylborates. The reaction conditions (stirring in CH2Cl2 at room temperature (Method A) or stirring with CH3COONa in CH2Cl2 at room temperature (Method B) or refluxing in the CH2Cl2/toluene mixture (Method C)) controlled the formation and relative content of these compounds in the reaction mixtures from one to three products. Substituted oxazaborines gradually rearranged into diazaborinones at 250 °C. The prepared compounds were characterized by1H NMR,13C NMR, IR, and UV–Vis spectroscopy, HRMS, or microanalysis. The structure of individual compounds was confirmed by11B NMR,15N NMR, 1D NOESY, and X-ray analysis. The mechanism of reaction of enaminoamides with 4-methylbenzenediazonium tetraphenylborate was proposed.

Preparation method of 3-aminobutyramide type compound

The invention discloses a preparation method of a 3-aminobutyramide type compound. The preparation method includes the following steps: 1) performing a reaction to a compound (I) as a raw material in ammonia water at 20-70 DEG C to produce a compound (II) after the reaction is completed; 2) adding the compound (II) to a solvent, and performing a reductive hydrogenation reaction at 30-50 DEG C under 0.1-1.5 MPa to produce a compound (III), Raney nickel being a catalyst. The preparation method is simple in processes and has gentle conditions and is composed of common ammonolysis reaction and hydrogenation reduction reaction (ammonolysis reactions in the prior art require high-pressure equipment and are high in energy consumption), wherein an ammonolysis mother liquid can be directly recycled, so that the preparation method has simple operations. The product is high in yield and purity, wherein total yield is more than 77% and purity is more than 98%. The method is suitable for industrial production of the 3-aminobutyramide type compound and is environment-friendly.