15959-53-2

Basic information

• Product Name: N-Phenylsulfamide
• Synonyms: N-Phenylsulfamide
• CAS NO: 15959-53-2
• Molecular Formula: C₆H₈N₂O₂S
• Molecular Weight: 172.2
• Mol File: 15959-53-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Phenylsulfamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Phenylsulfamide(15959-53-2)
• EPA Substance Registry System: N-Phenylsulfamide(15959-53-2)

Safety Data

• Hazardous Substances Data: 15959-53-2(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 17763-67-6 Phenyl triflate 
• 108-90-7 chlorobenzene 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 153028-13-8 N-(tert-butoxycarbonyl)-N'-(phenyl)sulfamide 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 371-40-4 4-fluoroaniline 
• 100-46-9 benzylamine 
• 5631-35-6 1-[4,4-bis(4-fluorophenyl)butyl]piperazine 
• 107-85-7 1-amino-3-methylbutane 
• 104-94-9 4-methoxy-aniline 
• 110-89-4 piperidine 
• 49689-92-1 N-tert-Butyl-N'-phenyl-sulfamid 

Downstream Products

• 20619-96-9 μ-imido-disulfuric acid dianilide 
• 130669-78-2 3,7-Diphenyl-2,6,1,3,5,7-dithiatetraazabicyclo<3.3.1>nonane 
• 133116-78-6 ethyl 2,2-dioxo-3,4-dihydro-2,1,3-benzothiadiazin-4-ylacetate 
• 133116-74-2 ethyl 4-carbethoxy-2-phenyl-1,1-dioxo-5,6-dihydro-2H-1,2,6-thiadiazin-5-ylacetate 
• 401907-25-3 1-(4-t-butylbenzyl)-3-(4-sulfamoylbenzyl)thiourea 
• 62002-27-1 N-(N-phenylsulfamoyl)benzamide 
• 497949-70-9 benzyl N-phenyl-sulfamoylcarbamate 
• 100377-64-8 N-(N-phenylsulfamoyl)acetamide 

Relevant articles and documents

Simple, rapid, and clean condensation of sulfonamide and maleic anhydride derivatives: Synthesis of novel 1H- Pyrrole-2,5-diones under heterogeneous conditions

H6P2W18O62is used as an efficient catalyst for the synthesis of novel N-substituted sulfonyl maleimides (1H-Pyrrole-2,5-diones) via the condensation of sulfonamide and maleic anhydride derivatives. The Dawson heteropolyacid was used with a catalytic amount of 2?mmol% in acetonitrile at reflux. The reuse of H6P2W18O62as heterogeneous catalyst several times without decrease in their activity, short reaction times, easy isolation of desired products with good to excellent yields shows the advantages of this novel methodology.

Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2am) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.

Synthesis of new substituted N-sulfonyl pyrrolidine-2,5-dione using dawson-type heteropolyacid as catalyst

The synthesis of new series of pyrrolidine-2,5-diones having sulfonamide moieties is described. These compounds are synthesized in good yield in three steps (carbamoylation-sulfamoylation, deprotection and condensation) using a catalytic amount of H6P2W18O62 in acetonitrile under refluxing conditions.

Convenient Synthesis of Novel N -Acylsulfonamides Containing Phosphonate Moiety

The present study describes a convenient method for the synthesis of new N-acylsulfonamides containing phosphonate moiety. The N-acylsulfonamides were prepared starting from chlorosulfonyl isocyanate (CSI) in four steps (carbamoylation, sulfamoylation, deprotection, and acylation). Trimethylphosphite has been used to introduce the phosphonate moiety into N-acylsulfonamides via Arbuzov reaction. GRAPHICAL ABSTRACT

An efficient method for the synthesis of novel n-acylsulfonamides using tin (IV) chloride as catalysts

A series of novel N-acylsulfonamides derivatives were synthesized via direct condensation of parent sulfonamide with ethyl lactate as an acylating agent in the presence of tin (IV) chloride (SnCl4) as a Lewis acid catalyst. The sulfonamides were prepared, starting from chlorosulfonyl isocyanate (CSI), in three steps (carbamoylation, sulfamoylation, and deprotection) with excellent yields. Copyright

Synthesis and antibacterial activity of sulfonamides. SAR and DFT studies

A series of substituted sulfonamide derivatives were synthesized from chlorosulfonyl isocyanate (CSI) in tree steps (carbamoylation, sulfamoylation and deprotection). Antibacterial activity in vitro of some newly formed compounds investigated against clinical strains Gram-positive and Gram-negative: Escherichia coli and Staphylococcus aureus applying the method of dilution and minimal inhibition concentration (MIC) methods. These compounds have significant bacteriostatic activity with totalities of bacterial strains used. DFT calculations with B3LYP/6-31G(d) level have been used to analyze the electronic and geometric characteristics deduced for the stable structure of three compounds presenting conjugation between a nitrogen atom N through its lone pair and an aromatic ring next to it. The principal quantum chemical descriptors have been correlated with the antibacterial activity.

N-(Alkylsulfamoyl)aldimines: Easily deprotected precursors for diarylmethylamine synthesis

The sequential reaction of chlorosulfonyl isocyanate with t-BuOH, t-BuNH2 and TFA allows formation of H2NSO 2NHBut. Condensation of the latter with Ar1CHO in the presence of Ti(OEt)4 provides the activated imines Ar 1CHNSO2NHBut (59-89%). Commercially available boronic acids add to these imines with good stereoselectivity (76-98% ee) using readily available diene ligands. Simple deprotection with 5% w/w water in pyridine affords free Ar1CHNH2Ar2.

NOVEL SULFONAMIDE DERIVATIVE

A compound of the formula (1): wherein m, n and p is independently an integer of 0 to 4 with the proviso that 3 a?| m + n a?| 8; X is the formula: NR4, etc.; R1, R3 and R4 are a substituted or unsubstituted aryl group, etc.; R2 is a hydrogen atom, etc.; a, b, c, d, e and f are a hydrogen atom or a substituted or unsubstituted alkyl group, etc.; Y is the formula: -SO2-, etc.; and Z is an oxygen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt of the same has an activity of potentiating an expression of a low density lipoprotein receptor and thus is useful as an agent for treating hyperlipidemia or arteriosclerosis.

Sulfamide synthesis via Pd-catalysed cross-coupling

A novel efficient procedure for the improved synthesis of aryl-substituted sulfamides via a Pd-catalysed arylation of sulfamide is reported.

Macrocyclic compounds as inhibitors of viral replication

The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.