171628-63-0

Basic information

• Product Name: N-phenyl-N'-(2-phenylimidazo[1,2-a]pyridin-3-yl)urea
• Synonyms: N-phenyl-N'-(2-phenylimidazo[1,2-a]pyridin-3-yl)urea
• CAS NO: 171628-63-0
• Molecular Formula: C20H16N4O
• Molecular Weight: 328.36724
• Mol File: 171628-63-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-phenyl-N'-(2-phenylimidazo[1,2-a]pyridin-3-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-N'-(2-phenylimidazo[1,2-a]pyridin-3-yl)urea(171628-63-0)
• EPA Substance Registry System: N-phenyl-N'-(2-phenylimidazo[1,2-a]pyridin-3-yl)urea(171628-63-0)

Safety Data

• Hazardous Substances Data: 171628-63-0(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 103-71-9 phenyl isocyanate 
• 171628-67-4 C₃₁H₂₄N₃P 
• 3999-29-9 2-phenylimidazo[1,2-a]pyridin-3-amine 
• 4926-52-7 2-chloro-3-nitroimidazo[1,2-a]pyridine 
• 126202-06-0 2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid 
• 3999-05-1 2-chloroimidazo[1,2-a]pyridine 
• 504-29-0 2-aminopyridine 
• 112581-95-0 2-Bromoimidazo[1,2-a]pyridine 
• 98-80-6 phenylboronic acid 
• 67625-22-3 2-bromo-3-nitro-imidazo[1,2-a]pyridine 
• 67292-98-2 3-nitro-2-phenylimidazo<1,2-a>pyridine 

Relevant articles and documents

Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a] pyridine: Expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Alternative strategies for functionalizing 2-chloro-3-nitroimidazo[1,2-a] pyridine have been developed. Suzuki-Miyaura cross-coupling reaction provided easily the corresponding 2-arylated compounds, and herefrom the nitro group was reduced into amine which afforded amides, anilines, and ureas in the 3-position. The amination of the key compound using a metal-catalyzed reaction was reported. This study highlighted the importance of the nitro group to facilitate the chlorine displacement. Other nucleophilic aromatic substitutions open a route to various products derived from imidazo[1,2-a]pyridine.

EFFECTIVE STRATEGY FOR THE SYNTHESIS OF PYRIDOIMIDAZOISOQUINOLINE SYSTEM

Annulation of 3-aceta(benza)mido-2-phenylimidazopyridines (2a,b) by phosphorus oxychloride results in the formation of pyridoimidazoisoquinolines (3a,b) as potent antileukemic structures.An alternative route for obtaining the isoquinoline framework was centered on the aza-Wittig reaction of iminophosphorane (4) with different isocyanates.