67292-98-2Relevant academic research and scientific papers
Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors
Rostrup, Frederik,Falk-Petersen, Christina B.,Harpsoe, Kasper,Buchleithner, Stine,Conforti, Irene,Jung, Sascha,Gloriam, David E.,Schirmeister, Tanja,Wellendorph, Petrine,Frolund, Bente
, p. 4730 - 4743 (2021/05/06)
Despite the therapeutic relevance of δ-containing γ-aminobutyric acid type A receptors (GABAARs) and the need for δ-selective compounds, the structural determinants for the mode and molecular site of action of δ-selective positive allosteric modulator imi
Novel approach in the synthesis of imidazo [1, 2-a] pyridine from phenyl acrylic acids
Mutkule, Nilesh,Bugad, Nageshprasad,Mokale, Santosh,Choudhari, Vilas,Ubale, Milind
, p. 3186 - 3192 (2020/06/23)
This paper describes highly efficient concise method for the synthesis of imidazo[1,2-a] pyridine. It is a first report employing, amino pyridines, copper nitrate, and phenyl acrylic acids in the synthesis of imidazo[1,2-a] pyridine. The silent features of the devised protocol include the high yield, milder reaction conditions, and shorter reaction time.
NIS-promoted multicomponent reaction of 2-aminopyridines with aldehydes and nitromethane for the synthesis of 3-nitroimidazo[1.2-a]pyridines
Sun, Jinwei,Yang, Xinrui,Liu, Yun,Wang, Yi,Pan, Yi
, p. 1449 - 1455 (2020/02/05)
An efficient synthesis of 3-nitroimidazo[1,2-a]pyridines has been developed via N-iodosuccinimide (NIS)-mediated multicomponents reaction of 2-aminopyridines, aldehydes, and nitromethane under metal-free conditions. This protocol has many advantages such as broad substituent scope, mild and eco-friendly conditions, high step economy, and good yields.
Superparamagnetic nanoparticle-catalyzed coupling of 2-amino pyridines/pyrimidines with trans-chalcones
Nguyen, Oanh T. K.,Ha, Pha T.,Dang, Ha V.,Vo, Yen H.,Nguyen, Tung T.,Le, Nhan T. H.,Phan, Nam T. S.
, p. 5501 - 5511 (2019/03/02)
An aerobic coupling of 2-aminopyrimidines or 2-aminopyridines with trans-chalcones to afford aroylimidazo[1,2-a]pyrimidines and aroylimidazo[1,2-a]pyridines is reported. Reactions proceed in the presence of CuFe2O4 superparamagnetic
Synthesis and biological evaluation of novel benzimidazole derivatives and analogs targeting the NLRP3 inflammasome
Pan, Liangkun,Hang, Nan,Zhang, Chao,Chen, Yu,Li, Shuchun,Sun, Yang,Li, Zhongjun,Meng, Xiangbao
, (2017/03/09)
A series of benzo[d]imidazole analogues of thiabenzole were synthesized and their anti-inflammatory activities toward NLRP3 (nucleotide-binding domain leucine-rich repeat containing protein family, pyrin domain-containing 3, also known as cryopyrin or NALP3) inflammasome were evaluated in vitro. Two lead compounds, TBZ-09 and TBZ-21, were identified by anti-production of IL-1β. In the second round of biological evaluation, based on the lead, 34 more compounds were synthesized and their in vitro anti-inflammatory activities were investigated. Several compounds were identified as anti-inflammatory agents that can reduce IL-1β expression in a dose-dependent manner. A preliminary structure-activity relationship is also summarized here.
HETERO-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME
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, (2016/10/08)
The present specification relates to a novel heterocyclic compound and an organic light-emitting device using the same. According to one embodiment of the present specification, provided is a compound in chemical formula 1. The compound of the present specification can be used as an organic matter layer material of an organic light-emitting device.COPYRIGHT KIPO 2016
Metal-free oxidative coupling of aminopyridines with nitroolefins to imidazo [1,2-α]pyridine in the presence of i2-tbhp-pyridine
An, Litao,Sun, Xiaojun,Lv, Meng,Zhou, Jianfeng,Zhu, Fengxia,Zhong, Hui
, p. 141 - 147 (2016/04/26)
A facile metal-free approach to the synthesis of imidazo [1,2-α]pyridine was developed through a tandem reaction of Michael addition and oxidative coupling. Iodine-t-butyl hydroperoxide-pyridine was found to be a green and efficient catalytic system for t
Magnetic carbon nanotube supported Cu (CoFe2O4/CNT-Cu) catalyst: A sustainable catalyst for the synthesis of 3-nitro-2-arylimidazo[1,2-a]pyridines
Zhang, Mo,Lu, Jun,Zhang, Jia-Nan,Zhang, Zhan-Hui
, p. 26 - 32 (2016/02/23)
A magnetic carbon nanotube supported Cu catalyst (CoFe2O4/CNT-Cu) was prepared, characterized and evaluated as a recoverable catalyst for synthesis of 3-nitro-2-arylimidazo[1,2-a]pyridines via one-pot three-component reactions of 2-a
Synthesis of imidazo [1, 2 - α] pyridine derivatives of a simple method for
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Paragraph 0032-0035, (2019/02/02)
The invention relates to a simple method for synthesizing imidazo (1,2-a) pyridine derivatives. The method comprises the steps of: dissolving reactants including 2-aminopyridine or derivatives thereof and beta-nitrostyrolene or derivatives thereof into a
Metal-free synthesis of imidazopyridine from nitroalkene and 2-aminopyridine in the presence of a catalytic amount of iodine and aqueous hydrogen peroxide
Tachikawa, Yuma,Nagasawa, Yoshitomo,Furuhashi, Sohei,Cui, Lei,Yamaguchi, Eiji,Tada, Norihiro,Miura, Tsuyoshi,Itoh, Akichika
, p. 9591 - 9593 (2015/03/03)
We have developed a metal-free synthetic method for 3-nitroimidazo[1,2-a]pyridines from nitroalkenes and 2-aminopyridines using catalytic amounts of iodine and aqueous hydrogen peroxide as a terminal oxidant.
