112581-95-0

Basic information

• Product Name: 2-BROMOIMIDAZO[1,2-A]PYRIDINE
• Synonyms: 2-Bromoimidazo[1,2-a]pyridine;2-broMoindolizine;IMidazo[1,2-a]pyridine, 2-broMo-;2-broMo-1,5-dihydroiMidazo[1,2-a]pyridine;2-BroMoiMidazo
• CAS NO: 112581-95-0
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.03
• Product Categories: Heterocycle-Pyridine series
• Mol File: 112581-95-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.697 g/cm³
• Refractive Index: 1.688
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.86±0.50(Predicted)
• CAS DataBase Reference: 2-BROMOIMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOIMIDAZO[1,2-A]PYRIDINE(112581-95-0)
• EPA Substance Registry System: 2-BROMOIMIDAZO[1,2-A]PYRIDINE(112581-95-0)

Safety Data

• Hazardous Substances Data: 112581-95-0(Hazardous Substances Data)

Usage

General Description

2-Bromoimidazo[1,2-a]pyridine is a chemical compound that belongs to the class of organic compounds known as imidazo[1,2-a]pyridines. These are aromatic heterocyclic compounds containing a pyridine ring fused to an imidazole ring. 2-Bromoimidazo[1,2-a]pyridine is characterized by the presence of a bromide group attached to it. It is mainly used in the field of organic chemistry where it serves as a useful synthetic intermediate. Its properties, such as reactivity and stability, can be manipulated depending on the needs of the particular synthesis. However, like many brominated substances, safety precautions must be taken when handling it, due to risks associated with bromine toxicity.

InChI:InChI=1/C7H5BrN2/c8-6-5-10-4-2-1-3-7(10)9-6/h1-5H

Upstream product

• 504-29-0 2-aminopyridine 
• 471-25-0 Propiolic acid 
• 105-36-2 ethyl bromoacetate 
• 126202-06-0 2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid 

Downstream Products

• 4044-95-5 2-Phenyl-3-bromoimidazo<1,2-a>pyridine 
• 64413-90-7 3-iodo-2-phenylimidazo[1,2-α]pyridine 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 139705-74-1 2-(4-aminophenyl)imidazo<1,2-a>pyridine 
• 67292-98-2 3-nitro-2-phenylimidazo<1,2-a>pyridine 
• 1452807-23-6 2-phenyl-N-(pyridin-3-yl)imidazo[1,2-a]pyridin-3-amine 
• 1452807-22-5 N-(4-chlorophenyl)-2-phenylimidazo[1,2-a]pyridin-3-amine 
• 1072106-67-2 C₁₉H₁₄N₄O₂ 
• 1110272-22-4 N,2-diphenylimidazo[1,2-a]pyridin-3-amine 
• 1189902-53-1 C₂₁H₁₈N₄O 
• 171628-63-0 1-Phenyl-3-(2-phenyl-imidazo[1,2-a]pyridin-3-yl)-urea 
• 1296335-75-5 C₂₀H₂₂N₄O 
• 1452807-21-4 C₁₈H₂₀N₄O 
• 1452807-20-3 C₁₇H₁₈N₄O 

Relevant articles and documents

A Cu(II)-promoted tandem decarboxylative halogenation and oxidative diamination reaction of 2-aminopyridines with alkynoic acids for the synthesis of 2-haloimidazo[1,2-: A] pyridines

A copper-promoted cascade decarboxylative halogenation and oxidative diamination reaction sequence of 2-aminopyridines with alkynoic acids has been developed for the synthesis of 2-haloimidazo[1,2-a]pyridines. In this reaction, two C-N bonds and one C-halogen bond are formed in one pot, generating the desired products in good yields. This is the first report on the synthesis of 2-haloimidazo[1,2-a]pyridine derivatives from alkynoic acids.

An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridin-2-yl triflate through a Suzuki cross-coupling reaction-direct arylation sequence

An efficient method to prepare 2,3-diarylimidazo[1,2-a]pyridines is described. The procedure involves a Suzuki cross-coupling reaction followed by a direct arylation at position 3. Imidazo[1,2-a]pyridin-2-yl triflate was identified as a suitable coupling partner, permitting access to a variety of highly functionalized 2,3-diarylimidazo[1,2-a]pyridines.