- New 2,2′-substituted 4,4′-dimethoxy-6,6′-dimethyl[1, 1′-biphenyls], inducing a strong helical twisting power in liquid crystals
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Based on the stabilisation of the molecular motion by the chiral residue, novel optically active biphenylic chiral dopants for nematic liquid crystals were developed. This molecular congestion was obtained by introducing mesogenic residues on the 2,2′-positions of the chiral biphenyl; this led to a novel molecular architecture that was found to be efficient. The synthesised optically active biphenyls were characterised with very short cholesteric pitches when used as chiral dopants in nematic liquid crystals. The synthesis of the enatiomerically pure biphenyl dopants and their preliminary physicochemical characterisations are described.
- Holzwarth, Richard,Bartsch, Richard,Cherkaoui, Zoubair,Solladie, Guy
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p. 3931 - 3935
(2007/10/03)
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- Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
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Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
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- NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS
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Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
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- A New Family of Enantiomerically Pure Smectic C* Liquid Crystals with a Bridged Chiral Biphenyl Core
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The synthesis of enantiomerically pure bridged biphenyl compounds, (-)-(R)-3,9-bis(4-(dodecyloxy)benzoyloxy)-5,7-dihydro-1,11-dimethyldibenzo[c,e] thiepine, 13, and (-)-(R)-3,9-bis(4-(dodecyloxy)benzoyloxy)-5,7-dihydro-1,11-dimethyldibenzo[c,e]- thiepin d
- Solladie, Guy,Hugele, Philippe,Bartsch, Richard
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p. 3895 - 3898
(2007/10/03)
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- SYNTHESIS OF OPTICALLY ACTIVE O,O,O-TRIMETHYLKORUPENSAMINES A AND B
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Hydrolysis of benzofuran derivative (10) with concomitant aromatisation produced the biaryl system (11).Subsequent Sharpless asymmetric epoxidation of the cinnamyl alcohol (13) gave atropisomers (14) and (15) conveniently separated by chromatography.Indep
- Rao, A. V. Rama,Gurjar, Mukund K.,Ramana, D. Venkata,Chheda, Abhay K.
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