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4-QUINOLINECARBOXYLIC ACID,7-METHOXY-2-PHENYL- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 174636-63-6 Structure
  • Basic information

    1. Product Name: 4-QUINOLINECARBOXYLIC ACID,7-METHOXY-2-PHENYL-
    2. Synonyms: 4-QUINOLINECARBOXYLIC ACID,7-METHOXY-2-PHENYL-
    3. CAS NO:174636-63-6
    4. Molecular Formula: C17H13NO3
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 174636-63-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-QUINOLINECARBOXYLIC ACID,7-METHOXY-2-PHENYL-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-QUINOLINECARBOXYLIC ACID,7-METHOXY-2-PHENYL-(174636-63-6)
    11. EPA Substance Registry System: 4-QUINOLINECARBOXYLIC ACID,7-METHOXY-2-PHENYL-(174636-63-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 174636-63-6(Hazardous Substances Data)

174636-63-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 174636-63-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,6,3 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 174636-63:
(8*1)+(7*7)+(6*4)+(5*6)+(4*3)+(3*6)+(2*6)+(1*3)=156
156 % 10 = 6
So 174636-63-6 is a valid CAS Registry Number.

174636-63-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-methoxy-2-phenylquinoline-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 7-Methoxy-2-phenyl-chinolin-4-carbonsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:174636-63-6 SDS

174636-63-6Relevant articles and documents

Quinoline STAT3 specific inhibitor, and preparation method and applications thereof

-

Paragraph 0050; 0054-0056, (2019/10/01)

The invention discloses a quinoline STAT3 specific inhibitor, and a preparation method and applications thereof. The structure of the quinoline STAT3 specific inhibitor is represented by formula I. The quinoline STAT3 specific inhibitor possesses obvious

MACROCYCLIC SERINE PROTEASE INHIBITORS

-

Page/Page column 158, (2009/03/07)

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising such compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework

Giardina, Giuseppe A. M.,Sarau, Henry M.,Farina, Carlo,Medhurst, Andrew D.,Grugni, Mario,Raveglia, Luca F.,Schmidt, Dulcie B.,Rigolio, Roberto,Luttmann, Mark,Vecchietti, Vittorio,Hay, Douglas W. P.

, p. 1794 - 1807 (2007/10/03)

A novel class of potent and selective non-peptide neurokinin-3 (NK-3) receptor antagonists, featuring the 4-quinolinecarboxamide framework, has been designed based upon chemically diverse NK-1 receptor antagonists. The novel compounds 33-76, prompted by chemical modifications of the prototype 4, have been characterized by binding analysis using a membrane preparation of chinese hamster ovary (CHO) cells expressing the human neurokinin-3 receptors (hNK-3-CHO), and clear structure-activity relationships (SARs) have been established. From SARs, (R)-N-[α-(methoxycarbonyl)benzyl]-2- phenylquinoline-4-carboxamide (65, SB 218795, hNK-3-CHO binding K(i) = 13 nM) emerged as one of the most potent compounds of this novel class. Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding K(i) = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding K(i) = >100 μM). In vitro functional studies in rabbit isolated iris sphincter muscle preparation demonstrated that 65 is a competitive antagonist of the contractile response induced by the potent and selective NK-3 receptor agonist senktide with a K(b) = 43 nM. Overall, the data indicate that 65 is a potent and selective hNK-3 receptor antagonist and a useful lead for further chemical optimization.

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