- Growth dynamics and molecular structural analysis of Dimethylketo thiosemicarbazone single crystals for frequency conversion applications - Optical and thermal characterization
-
New organic Schiff base of Dimethylketo thiosemicarbazone (DMKT) was synthesized by condensation process and grown by solvent slow evaporation method in methanol solution. The grown crystal was subjected to a single crystal and powder X-ray diffraction study and to identify that the material crystallized into a triclinic crystal system with a P-1 noncentrosymmetric space group. The X-Ray data reveals that the crystalline network cohesion of this compound. The FT-IR and FT Raman spectral analysis show the vibration behavior of chemical bonds in the grown material. Its optical behavior was examined by UV–VIS spectrum and the DMKT crystal was found to have transparency in the region between 350 nm and 1100 nm. The luminescent emission of the grown material was identified from the fluorescence spectrum. Improvement in the second harmonic generation efficiency of the grown material was studied by the Kurtz and Perry powder method and it shows 26.7 mV of green light emission. The thermal stability and melting point of DMKT were confirmed by various thermal analyses.
- Sakunthaladevi,Jothi
-
-
Read Online
- Synthesis and antimicrobial activities of novel 6-(1,3-thiazol-4-yl)-1,3- benzoxazol-2(3H)-one derivatives
-
Synthesis, characterization and investigation of antimicrobial activities of seven new 6-(1,3-thiazol-4-yl)-1,3-benzoxazol-2(3H)-ones are presented. Their structures were determined using 1H NMR, 13C NMR and elemental analyses. The compounds possess some biological activity against Gram-positive bacteria, especially against Micrococcus luteus belonging to opportunistic pathogens, with an MIC of 31.25 μg/mL.
- Laczkowski, Krzysztof Z.,Misiura, Konrad,Biernasiuk, Anna,Malm, Anna,Grela, Izabela
-
-
Read Online
- Novel 1,3-thiazolidin-4-one derivatives as promising anti- Candida agents endowed with anti-oxidant and chelating properties
-
Pursuing our recent outcomes regarding the antifungal activity of N-substituted 1,3-thiazolidin-4-ones, we synthesized thirty-six new derivatives introducing aliphatic, cycloaliphatic and heteroaromatic moieties at N1-hydrazine connected with C2 position of the thiazolidinone nucleus and functionalizing the lactam nitrogen with differently substituted (NO2, NH2, Cl and F) benzyl groups. These compounds were tested to evaluate their minimum inhibitory concentration (MIC) against several clinical Candida spp. with respect to topical and systemic reference drugs (clotrimazole, fluconazole, ketoconazole, miconazole, tioconazole, amphotericin B). Moreover, anti-oxidant properties were also evaluated by using different protocols including free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum assays. Moreover, for the most active derivatives we assessed the toxicity (CC50) against Hep2 human cells in order to characterize them as multi-target agents for fungal infections.
- Secci, Daniela,Carradori, Simone,Bizzarri, Bruna,Chimenti, Paola,De Monte, Celeste,Mollica, Adriano,Rivanera, Daniela,Zicari, Alessandra,Mari, Emanuela,Zengin, Gokhan,Aktumsek, Abdurrahman
-
-
Read Online
- Unusual chemical transformations of acetone thiosemicarbazone mediated by ruthenium: C-H bond activation, thiolation, and C-N bond cleavage
-
Upon reaction with Ru(PPh3)3Cl2 in ethanol in the presence of triethylamine, acetone thiosemicarbazone undergoes several interesting chemical transformations, such as thiolation via methyl C-H bond activation, C-N bond cleavage, and conversion of the CS fragment to CO. Two complexes (1 and 2) were obtained from this reaction, both of which contained a modified thiosemicarbazone coordinated in SNS- or SNO-mode, two triphenylphosphines and a N-bound thiocyanate. The crystal structures of both the complexes have been determined. Theoretical and mass spectral studies have been carried out to probe the transformations. These complexes show intense absorptions in the visible and ultraviolet regions. Cyclic voltammetry on both the complexes show a reversible oxidation near 0.6 V vs. SCE, followed by an irreversible oxidation near 1.2 V vs. SCE. DFT calculations have been carried out to explain the electronic spectra, as well as the electrochemical observations.
- Paul, Piyali,Seth, Dipravath Kumar,Richmond, Michael G.,Bhattacharya, Samaresh
-
-
Read Online
- Synthesis, spectra and crystal structure of two copper(I) complexes of acetonethiosemicarbazone
-
The reaction of copper(I) chloride with acetonethiosemicarbazone (tscac) in a copper to tscac molar ratio of 1:2 forms the cationic complex [Cu(tscac)2]Cl (1). When the ratio of the copper to tscac was reduced to 1:1, a dimeric complex [Cu2Cl2(tscac)2]2 (2) was obtained. In complex 2, two CuCl2 species act as bridging groups between two Cu(tscac)2 moieties forming an eight-membered ring, whereas in complex 1, there is no CuCl2 moiety in the structure. In both complexes the copper(I) center is coordinated in a distorted tetrahedral geometry to two tscac groups through the sulfur and the imine nitrogen atom. In dimeric complex 2, the sulfur atom in each tscac ligand coordinates weakly to copper(I) in the CuCl2 moiety giving the distorted tetrahedral geometry. For the free ligand, the vc=s vibration at 789 cm-1 appears at lower energy than in complexes 1 and 2 (754 and 744 cm-1 respectively) indicating coordination at the sulfur atom. The complexes synthesized by either electrochemical or chemical methods are identical. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
- Lhuachan, Sanchai,Siripaisarnpipat, Sutatip,Chaichit, Narongsak
-
-
Read Online
- CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF
-
The present application relates to novel semicarbazones and thiosemicarbazones, to processes for preparing them, to pharmaceutical preparations comprising them, to the use of the novel semicarbazones and thiosemicarbazones for treatment and/or prophylaxis of diseases and to the use thereof for production of a medicament for treatment and/or prophylaxis of diseases, especially of neurodegeneration and age-associated diseases or conditions associated with NAD loss. The present application also provides a method for high throughput screening of NMNAT2 activators.
- -
-
Page/Page column 22-23; 28; 32
(2020/06/22)
-
- Expedient routes to 1,2,4-triazolinium salts
-
Concomitant S-alkylation and ketazonation of thiosemicarbazide in acetone eventually led to unanticipated ring closure and formation of (3-alkylthio)-1,2,4-triazolinium salts. This initial finding was complemented by employing another three representative aldehydes and ketones. Supplementarily, some respective intermediates have been isolated by stepwise synthetic procedures. In addition to the usual spectroscopic characterization, the structures of six 1,2,4-triazolinium heterocycles, as well as two unexpected by-products thereof have been characterized by single-crystal X-ray diffraction.
- Fliri, Lukas,Partl, Gabriel,Gelbrich, Thomas,Nerdinger, Sven,Wurst, Klaus,Schottenberger, Herwig
-
p. 593 - 610
(2020/01/31)
-
- THIAZOLE DERIVATIVE AND APPLICATIONS
-
A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.
- -
-
Paragraph 0091-0092
(2019/04/16)
-
- Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents
-
New 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives are proposed as dual-target-directed monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) inhibitors, as well as antioxidant agents, for the treatment of neurodegenerative disorders such as Parkinson's disease. Rational molecular design, target recognition and predicted pharmacokinetic properties have been evaluated by means of molecular modelling. Based on these properties, compounds were synthesized and evaluated in vitro as MAO-B and AChE inhibitors, and compared to the activities at their corresponding isozymes, monoamine oxidase A (MAO-A) and butyrylcholinesterase (BuChE), respectively. Anti-oxidant properties, potentially useful in the treatment of neurodegenerative disorders, have been also investigated in vitro. Among the evaluated compounds, three inhibitors may be considered as promising dual inhibitors of MAO-B and AChE, in vitro. MAO-B inhibition was also shown to be competitive and reversible for compound 19.
- Carradori, Simone,Ortuso, Francesco,Petzer, Anél,Bagetta, Donatella,De Monte, Celeste,Secci, Daniela,De Vita, Daniela,Guglielmi, Paolo,Zengin, Gokhan,Aktumsek, Abdurrahman,Alcaro, Stefano,Petzer, Jacobus P.
-
p. 1543 - 1552
(2017/11/27)
-
- Acetone thiosemicarbazide and preparation method thereof
-
The invention discloses a preparation method of acetone thiosemicarbazide. The preparation method comprises (1) putting raw materials for preparation into a reactor, (2) heating the raw materials to cause the chemical reaction, (3) when the reaction temperature is increased to 40 to 50 DEG C, carrying out vacuum pumping on the reactor and discharging the produced ammonia gas, (4) cooling the reactor to 30 DEG C and adding acetone into the reactor, (5) carrying out an exothermic reaction process on acetone and thiocyanate, and (6) when the reaction temperature is 50 to 80 DEG C, adding the reaction product into a reflux device to prevent the liquid evaporation so that acetone thiosemicarbazone is obtained. The preparation method has advantages of final product yield higher than 90% and product purity of 99%. The ingredients in the novel raw materials do not corrode the equipment. The by-product ammonia gas can be collected and processed to form ammonium hydroxide for recycling. The preparation method has a high yield and does not produce pressure on equipment and environment.
- -
-
Paragraph 0021; 0022; 0023; 0024; 0025; 0026-0077
(2017/06/02)
-
- Morphological and: In vitro evaluation of programmed cell death in MCF-7 cells by new organoruthenium(II) complexes
-
Cyclopentadienyl ruthenium(ii) thiosemicarbazone complexes with the general formula [Ru(η5-C5H5)(Ac-tsc)PPh3]·Cl (1), [Ru(η5-C5H5)(Ac-mtsc)PPh3]·Cl (2), [Ru(η5-C5H5)(Ac-etsc)PPh3]·Cl (3) and [Ru(η5-C5H5)(Ac-ptsc)PPh3] (4) were synthesized and characterized by various spectroscopic techniques (1H NMR, 13C NMR, IR and UV-vis). The molecular structures of the representative complexes 2 and 4 were studied by single-crystal X-ray diffraction. The interactions of all the ligands and complexes with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) were studied using UV-vis and fluorescence emission spectroscopy. The results of binding studies revealed that the effective binding potentials of the complexes were higher than those of their parent ligands. All the new complexes 1-4 were investigated for their in vitro cytotoxic activity against MCF-7 human breast cancer cell line. All the complexes significantly inhibited cell proliferation in MCF-7 cells in a dose-dependent manner. Cytological observations via an inverted phase contrast microscope and a Hoechst 33342/PI dual-staining assay showed typical apoptotic morphology of cancer cells upon treatment with complexes 2 and 3. It can thus be suggested that the complexes 2 and 3 are modulated by apoptosis. The findings of the present study indicated that complexes 2 and 3 may become potent drugs for the treatment of cancer-related diseases only after further investigation.
- Devagi,Reyhaneh,Dallemer,Jayakumar,Kalaivani,Prabhakaran
-
p. 8620 - 8636
(2017/08/15)
-
- Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity
-
With reference to recent studies reporting on the various biological properties of the thiazolidinone scaffold, we synthesized more than a hundred compounds characterized by a 1,3-thiazolidin-4-one nucleus derivatised at the C2 with a hydrazine bridge linked to (cyclo)aliphatic or hetero(aryl) moieties, and their N-benzylated derivatives. These molecules were assayed as potential anti-Candida agents and they were shown to possess comparable, and in some cases higher biological activity than well-established topical and systemic antimycotic drugs (i.e. clotrimazole, fluconazole, ketoconazole, miconazole, tioconazole, amphotericin B). Compounds endowed with the lowest MICs underwent further testing in order to assess their cytotoxic effect (CC50) on Hep2 cells, which demonstrated their relative safety. Finally, QSAR and 3-D QSAR models were used to predict putative chemical modifications of the 1,3-thiazolidin-4-one scaffold in order to design new and potential more active compounds against Candida spp.
- Carradori, Simone,Bizzarri, Bruna,D'Ascenzio, Melissa,De Monte, Celeste,Grande, Rossella,Rivanera, Daniela,Zicari, Alessanda,Mari, Emanuela,Sabatino, Manuela,Patsilinakos, Alexandros,Ragno, Rino,Secci, Daniela
-
p. 274 - 292
(2017/10/05)
-
- Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives
-
On the basis of the recent findings about the biological properties of thiazolidinones and taking into account the encouraging results about the antifungal activity of some (thiazol-2-yl)hydrazines, new N-substituted heterocyclic derivatives were designed combining the thiazolidinone nucleus with the hydrazonic portion. In details, 1,3-thiazolidin-4-ones bearing (cyclo)aliphatic or (hetero)aromatic moieties linked to the N1-hydrazine at C2 were synthesized and classified into three series according to the aromatic or bicyclic rings connected to the lactam nitrogen of the thiazolidinone. These molecules were assayed for their anti-Candida effects in reference to the biological activity of the conventional topic (clotrimazole, miconazole, tioconazole) and systemic drugs (fluconazole, ketoconazole, amphotericin B). Finally, we investigated the selectivity against fungal cells by testing the compounds endowed with the best MICs on Hep2 cells in order to assess their cell toxicity (CC50) and we noticed that two derivatives were less cytotoxic than the reference drug clotrimazole. Moreover, a preliminary molecular modelling approach has been performed against lanosterol 14-α demethylase (CYP51A1) to rationalize the activity of the tested compounds and to specify the target protein or enzyme.
- De Monte, Celeste,Carradori, Simone,Bizzarri, Bruna,Bolasco, Adriana,Caprara, Federica,Mollica, Adriano,Rivanera, Daniela,Mari, Emanuela,Zicari, Alessandra,Akdemir, Atilla,Secci, Daniela
-
-
- Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agents
-
It has been proven that inhibiting human dihydroorotate dehydrogenase (hDHODH) restricts the growth of rapidly proliferating cells, thus hDHODH can be developed as a promising target for the treatment of immunological disease and cancer. Here, a succession of substituted hydrazino-thiazole derivatives were designed, synthesized, and biologically evaluated through structure-based optimization, of which compound 22 was the most potent inhibitor of hDHODH with an IC50 value of 1.8 nM. Furthermore, 22 exhibited much better antiproliferative activity than brequinar, both in HCT-116 and BxPC-3 cancer cell lines. Flow cytometry analysis revealed that 22 induced S phase cell cycle arrest and promoted induction of apoptosis. All results established a proof that blocking the pyrimidine de novo synthesis pathway by inhibiting the rate-limiting enzyme hDHODH is an attractive therapy for cancer.
- Song, Wenlin,Li, Shiliang,Tong, Yi,Wang, Jiawei,Quan, Lina,Chen, Zhuo,Zhao, Zhenjiang,Xu, Yufang,Zhu, Lili,Qian, Xuhong,Li, Honglin
-
supporting information
p. 1441 - 1448
(2016/07/21)
-
- Efficient "on water" green route heterocyclization of thiosemicarbazones with DMAD
-
A simple, efficient, and eco-friendly procedure for the synthesis of thiazolidin-4-one derivatives in water from cyclocondensation reaction of thiosemicarbazone derivatives and dimethylacetylene dicarboxylate (DMAD) in good yield is reported. The regiochemistry of the cyclized products is established by elemental analysis, IR, NMR, and mass spectral data. A single crystal X-ray diffraction study of a representative compound, 3f, is reported.
- Singla, Rohit,Gautam, Deepika,Gautam, Poonam,Chaudhary
-
p. 740 - 745
(2016/05/09)
-
- Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma
-
Antimitotic agents are widely used in cancer chemotherapy but the numerous side effects and the onset of resistance limit their clinical efficacy. Therefore, with the purpose of discovering more selective and efficient anticancer agents to be administered alone or in combination with traditional drugs, we synthesized a large library of 1,3,4-thiadiazoline analogues, maintaining the pharmacophoric structure of an antiproliferative compound known as K858: this is a new inhibitor of kinesin Eg5, able to induce the mitotic arrest in colorectal cancer cells and in xenograft ovarian cancer cells. We screened 103 compounds to assess their antiproliferative activity on PC3 prostate cancer cell line. Two derivatives, compounds 32 (corresponding to K858) and 33, have shown to be the most effective against prostate tumor cells and also towards two melanoma cell lines (SK-MEL-5 and SK-MEL-28) at low micromolar concentrations, confirming the pharmacological activity of this scaffold and revealing the potential role of 1,3,4-thiadiazolines in the management of cancer.
- De Monte, Celeste,Carradori, Simone,Secci, Daniela,D'Ascenzio, Melissa,Guglielmi, Paolo,Mollica, Adriano,Morrone, Stefania,Scarpa, Susanna,Aglianò, Anna Maria,Giantulli, Sabrina,Silvestri, Ida
-
p. 245 - 262
(2015/11/03)
-
- Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors
-
Acetylation, which targets a broad range of histone and non-histone proteins, is a reversible mechanism and plays a critical role in eukaryotic genes activation/deactivation. Acetyltransferases are very well conserved through evolution. This allows the use of a simple model organism, such as budding yeast, for the study of their related processes and to discover specific inhibitors. Following a simple yeast-based chemogenetic approach, we have identified a novel HAT (histone acetyltransferase) inhibitor active both in vitro and in vivo. This new synthetic compound, 1-(4-(4-chlorophenyl)thiazol-2- yl)-2-(propan-2-ylidene)hydrazine, named BF1, showed substrate selectivity for histone H3 acetylation and inhibitory activity in vitro on recombinant HAT Gcn5 and p300. Finally, we tested BF1 on human cells, HeLa as control and two aggressive cancer cell lines: a neuroblastoma from neuronal tissue and glioblastoma from brain tumour. Both global acetylation of histone H3 and specific acetylation at lysine 18 (H3AcK18) were lowered by BF1 treatment. Collectively, our results show the efficacy of this novel HAT inhibitor and propose the utilization of BF1 as a new, promising tool for future pharmacological studies.
- Secci, Daniela,Carradori, Simone,Bizzarri, Bruna,Bolasco, Adriana,Ballario, Paola,Patramani, Zoi,Fragapane, Paola,Vernarecci, Stefano,Canzonetta, Claudia,Filetici, Patrizia
-
p. 1680 - 1689
(2014/03/21)
-
- Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies
-
Recently we described some (thiazol-2-yl)hydrazones as antiprotozoal, antifungal and anti-MAO agents as well as Gcn5 HAT inhibitors. Among these last compounds, CPTH2 and CPTH6 showed HAT inhibition in cells and broad anticancer properties. With the aim to identify HAT inhibitors more potent than the two prototypes, we synthesized several new (thiazol-2-yl)hydrazones including some related thiazolidines and pyrimidin-4(3H)-ones, and we tested the whole library existing in our lab against human p300 and PCAF HAT enzymes. Some compounds (1x, 1c', 1d', 1i' and 2m) were more efficient than CPTH2 and CPTH6 in inhibiting the p300 HAT enzyme. When tested in human leukemia U937 and colon carcinoma HCT116 cells (100 μM, 30 h), 1x, 1i' and 2m gave higher (U937 cells) or similar (HCT116 cells) apoptosis than CPTH6, and were more potent than CPTH6 in inducing cytodifferentiation (U937 cells).
- Carradori, Simone,Rotili, Dante,De Monte, Celeste,Lenoci, Alessia,D'Ascenzio, Melissa,Rodriguez, Veronica,Filetici, Patrizia,Miceli, Marco,Nebbioso, Angela,Altucci, Lucia,Secci, Daniela,Mai, Antonello
-
p. 569 - 578
(2014/06/09)
-
- Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii
-
We designed and synthesized a large number of novel thiazolidin-4-one derivatives for the evaluation of their anti-Toxoplasma gondii activity. This scaffold was functionalized at the N1-hydrazine portion with aliphatic, cycloaliphatic and (hetero)aromatic moieties. Then, a benzyl pendant was introduced at the lactamic NH of the core nucleus to evaluate the influence of this chemical modification on biological activity. The compounds were subjected to several in vitro assays to assess their anti-parasitic efficacy, cytotoxicity on fibroblasts, inhibition of tachyzoite invasion/attachment and replication after treatment. Results showed that fourteen of these thiazole-based compounds compare favorably to control compound trimethoprim in terms of parasite growth inhibition.
- D'Ascenzio, Melissa,Bizzarri, Bruna,De Monte, Celeste,Carradori, Simone,Bolasco, Adriana,Secci, Daniela,Rivanera, Daniela,Faulhaber, Nathan,Bordón, Claudia,Jones-Brando, Lorraine
-
-
- Microwave and ultrasound-assisted synthesis of thiosemicarbazones and their corresponding (4,5-substituted-thiazol-2-yl)hydrazines
-
Hantzsch cyclization of thiosemicarbazone intermediates is a very popular approach to the synthesis of substituted thiazoles. We developed a convenient microwave and ultrasound-assisted method both for the synthesis of 1-(alkyliden/cycloalkyliden/aryliden)thiosemicarbazone intermediates and their cyclization into (4,5-substituted-thiazol-2-yl)hydrazines. The search for optimal reaction conditions included the use of different catalysts (Lewis acids and resins) and solvents at discrete temperatures, pressures, and irradiation powers. Comparing yields, reaction times, and efforts proved that microwave and ultrasound-assisted techniques outmatch conventional heating and have a remarkable influence on the synthesis.
- Carradori, Simone,Secci, Daniela,D'Ascenzio, Melissa,Chimenti, Paola,Bolasco, Adriana
-
p. 1856 - 1861
(2015/02/02)
-
- Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents
-
Thirty-eight new (4-(4-substituted-phenyl/2,4-disubstituted-phenyl)- thiazol-2-yl)hydrazine derivatives were synthesized in good yield and assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-two clinical isolates of Candida spp. The concurrent presence of aliphatic chains or cycloaliphatic rings at N1-hydrazine and a 4-methyl/4-methoxyphenyl at C4 position of the thiazole nucleus exhibited an interesting anti-Candida inhibitory activity. Moreover, some of the most active compounds showed synergistic antifungal effects and lower cell toxicity when combined with clotrimazole.
- Carradori, Simone,Secci, Daniela,Bolasco, Adriana,Rivanera, Daniela,Mari, Emanuela,Zicari, Alessandra,Lotti, Lavinia Vittoria,Bizzarri, Bruna
-
p. 102 - 111
(2013/10/01)
-
- Synthesis, characterization, and anticancer activity of a series of ketone-N4-substituted thiosemicarbazones and their ruthenium(II) arene complexes
-
A series of ketone-N4-substituted thiosemicarbazone (TSC) compounds (L1-L9) and their corresponding [(η6-p-cymene)Ru II(TSC)Cl]+/0 complexes (1-9) were synthesized and characterized by NMR, IR, elemental analysis, and HR-ESI-mass spectrometry. The molecular structures of L4, L9, 1-6, and 9 were determined by single-crystal X-ray diffraction analysis. The compounds were further evaluated for their in vitro antiproliferative activities against the SGC-7901 human gastric cancer, BEL-7404 human liver cancer, and HEK-293T noncancerous cell lines. Furthermore, the interactions of the compounds with DNA were followed by electrophoretic mobility spectrometry studies.
- Su, Wei,Qian, Quanquan,Li, Peiyuan,Lei, Xiaolin,Xiao, Qi,Huang, Shan,Huang, Chusheng,Cui, Jianguo
-
p. 12440 - 12449
(2013/11/19)
-
- Investigations on the 2-thiazolylhydrazyne scaffold: Synthesis and molecular modeling of selective human monoamine oxidase inhibitors
-
A new series of [4-(3-methoxyphenyl)-thiazol-2-yl]hydrazyne derivatives were synthesized in good yield (71-99%) and characterized by elemental analysis and 1H NMR studies. The compounds were assayed for their in vitro human monoamine oxidase (hMAO) inhibitory activity and selectivity and most of them showed IC50 values in the nanomolar range, thus demonstrating our interest in this privileged scaffold. The most active and selective derivative (20), bearing a pyridine moiety on the CN, displayed IC50 = 3.81 ± 0.12 nM and selectivity ratio = 119 toward hMAO-B. Molecular modeling studies were carried out on recent and high resolution hMAO-A and hMAO-B crystallographic structures to better justify the enzyme-inhibitor interaction toward hMAO isoforms and to explain the structure-activity relationship of this kind of inhibitors.
- Chimenti, Franco,Bolasco, Adriana,Secci, Daniela,Chimenti, Paola,Granese, Arianna,Carradori, Simone,Yanez, Matilde,Orallo, Francisco,Ortuso, Francesco,Alcaro, Stefano
-
experimental part
p. 5715 - 5723
(2010/09/09)
-
- Synthesis and anti-Helicobacter pylori activity of 4-(coumarin-3-yl) thiazol-2-ylhydrazone derivatives
-
A novel class of coumarin-thiazole conjugated systems (1-31) were synthesized by Hantzsch condensation between α-bromo-3-acetyl coumarin and several thiosemicarbazone intermediates. This scaffold was also evaluated for selective antibacterial activity against 20 isolates of H. pylori clinical strains, including four metronidazole resistant ones.
- Chimenti, Franco,Bizzarri, Bruna,Bolasco, Adriana,Secci, Daniela,Chimenti, Paola,Granese, Arianna,Carradori, Simone,D'Ascenzio, Melissa,Scaltrito, M. Maddalena,Sisto, Francesca
-
experimental part
p. 1269 - 1274
(2011/01/05)
-
- A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds
-
A series of alkylidenethiosemicarbazide compounds were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that most of the synthesized compounds exhibited significant inhibitory activities. Especially, compound 1f was found to be the most potent inhibitor with IC50 value of 0.086 μM, suggesting that further development of such compounds may be of interest.
- Liu, Jinbing,Cao, Rihui,Yi, Wei,Ma, Chunming,Wan, Yiqian,Zhou, Binhua,Ma, Lin,Song, Huacan
-
experimental part
p. 1773 - 1778
(2009/05/26)
-
- M-STAGE KINESIN INHIBITOR
-
A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, -C(=W)R6 (wherein W represents an oxygen atom or a sulfur atom, and R6 represents substituted or unsubstituted lower alkyl and the like) and the like, R3 represents -C(=Z)R19 (wherein Z represents an oxygen atom or a sulfur atom, and R19 represents substituted or unsubstituted lower alkyl and the like) and the like, R4 represents substituted or unsubstituted lower alkyl and the like, and R5 represents substituted or unsubstituted aryl and the like] and the like are provided.
- -
-
Page/Page column 68
(2010/11/08)
-
- THIADIAZOLINE DERIVATIVE
-
(wherein R1 and R4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R2 represents -C(-W)R6 or the like; R3 represents a hydrogen atom, -C(=WA)R6A, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.
- -
-
-
