18303-02-1

Basic information

• Product Name: (p-Tolylsulfonyl)carbamic acid isopropyl ester
• Synonyms: (p-Tolylsulfonyl)carbamic acid isopropyl ester;[(4-Methylphenyl)sulfonyl]carbamic acid isopropyl ester
• CAS NO: 18303-02-1
• Molecular Formula: C₁₁H₁₅NO₄S
• Molecular Weight: 0
• Mol File: 18303-02-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (p-Tolylsulfonyl)carbamic acid isopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (p-Tolylsulfonyl)carbamic acid isopropyl ester(18303-02-1)
• EPA Substance Registry System: (p-Tolylsulfonyl)carbamic acid isopropyl ester(18303-02-1)

Safety Data

• Hazardous Substances Data: 18303-02-1(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 127-65-1 chloroamine-T 
• 67-63-0 isopropyl alcohol 
• 70-55-3 toluene-4-sulfonamide 
• 108-23-6 isopropyl chloroformate 
• 14437-03-7 methyl tosylcarbamate 
• 941-55-9 4-toluenesulfonyl azide 
• 13939-06-5 molybdenum hexacarbonyl 

Relevant articles and documents

Sulfonyl Azides as Precursors in Ligand-Free Palladium-Catalyzed Synthesis of Sulfonyl Carbamates and Sulfonyl Ureas and Synthesis of Sulfonamides

(Chemical Equation Presented). An efficient synthesis of sulfonyl carbamates and sulfonyl ureas from sulfonyl azides employing a palladium-catalyzed carbonylation protocol has been developed. Using a two-chamber system, sulfonyl azides, PdCl2, and CO gas, released ex situ from Mo(CO)6, were assembled to generate sulfonyl isocyanates in situ, and alcohols and aryl amines were exploited as nucleophiles to afford a broad range of sulfonyl carbamates and sulfonyl ureas. A protocol for the direct formation of substituted sulfonamides from sulfonyl azides and amines via nucleophilic substitution was also developed.

Microwave Promoted Transcarbamylation Reaction of Sulfonylcarbamates under Continuous-Flow Conditions

Successful conditions for the transcarbamylation/transesterification reaction of sulfonylcarbamates with alcohols by microwave heating under continuous-flow conditions were developed. After optimization of the processes, two series of O-alkylsulfonylcarbamates were obtained in high yields and purities using microwave transparent borosilicate tube reactors. In order to also illustrate the usefulness of the protocol in a medicinal chemistry context, the methodology was used for the synthesis of three angiotensin II type 2 receptor ligands.

Synthesis of arylsulfonylcarbamic acid derivatives using a new, phosgene-free method

Arylsulfonylcarbamic acid esters, thioesters, and amides, 3, have been prepared via catalytic carbonylation of alkali metal salts of N-chloroarylsulfonamides, 1, and treatment of the reaction mixture with R1XH (X=O, S, NR2).

N-arylsulfonyl carbamates

The present invention relates to amine, alkali metal and alkaline earth metal salts of N-benzene sulfonyl carbamic acid esters and to lower alkenyl N-benzene sulfonyl carbamates. These compounds are useful as herbicides.