- Preparation method and application of dimenephrine hydrochloride intermediate 7-methoxy-3-methyl flavone
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The invention provides a preparation method of a dimenephrine hydrochloride intermediate 7-methoxy 3-methyl flavone, which comprises the following steps: carrying out cyclization reaction on a compound IIa: 2, 4-dihydroxy propiophenone and a compound IIb: benzoyl chloride under the action of sodium benzoate to obtain a compound III: 7-methoxy-3-methyl flavone; according to the preparation method of the intermediate 7-methoxy-3-methyl flavone, provided by the invention, methylated 2, 4-dihydroxy propiophenone and benzoyl chloride are synthesized by adopting a one-step method, so that the prepared intermediate 7-methoxy-3-methyl flavone is high in purity, few in process impurities, high in yield and simple to operate; the invention further provides application of the 7-methoxy 3-methyl flavone in preparation of the dimenephrine hydrochloride, the yield of the dimenephrine hydrochloride is higher, and the specific preparation operation process is simple.
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Paragraph 0017-0022
(2021/04/10)
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- Synthesis of 3-methylflavones and their antioxidant and antibacterial activities
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An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria.
- Jayashree, B. S.,Alam, Afroze,Vijay Kumar, D.,Nayak, Yogendra
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p. 1991 - 1996,6
(2020/07/30)
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- Antioxidant and antibacterial activity of new 3-methylflavones
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Synthesis of new 3-methylflavones with various substitution on the ring A and B is being described. They were evaluated for antioxidant and antibacterial activity against Gram positive and Gram negative bacteria. Test compounds such as F-4,9,11,12 and 20
- Jayashree,Alam, Afroze,Kumar, D. Vijay,Nayak, Yogendra
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experimental part
p. 237 - 240
(2011/12/15)
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