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8-Methoxy-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one, commonly known as oxcarbazepine, is a chemical compound that functions as an antiepileptic drug. It is structurally related to carbamazepine and eslicarbazepine and operates by inhibiting the propagation of seizure activity in the brain. Oxcarbazepine is a prodrug, metabolized into its active form within the body, and is available in tablet or oral suspension form. It is generally well-tolerated, with common side effects such as dizziness, drowsiness, and headache.

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  • 187601-84-9 Structure
  • Basic information

    1. Product Name: 8-methoxy-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
    2. Synonyms: 8-methoxy-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
    3. CAS NO:187601-84-9
    4. Molecular Formula: C11H13NO2
    5. Molecular Weight: 191
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 187601-84-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 8-methoxy-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 8-methoxy-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one(187601-84-9)
    11. EPA Substance Registry System: 8-methoxy-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one(187601-84-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 187601-84-9(Hazardous Substances Data)

187601-84-9 Usage

Uses

Used in Pharmaceutical Industry:
8-Methoxy-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one is used as an antiepileptic medication for the treatment of partial seizures. It is prescribed due to its ability to inhibit the spread of seizure activity in the brain, providing relief to patients suffering from epilepsy.
Used in Neurological Treatment:
Oxcarbazepine is utilized as a therapeutic agent in the management of neurological conditions characterized by seizures. Its efficacy in controlling seizure activity makes it a valuable component in the treatment plans for individuals with epilepsy.
Used in Drug Development Research:
As a prodrug, 8-Methoxy-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one is also used in research for the development of new antiepileptic drugs. Its metabolism and mechanism of action provide insights into the design of potentially more effective or safer medications for seizure disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 187601-84-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,6,0 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 187601-84:
(8*1)+(7*8)+(6*7)+(5*6)+(4*0)+(3*1)+(2*8)+(1*4)=159
159 % 10 = 9
So 187601-84-9 is a valid CAS Registry Number.

187601-84-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-methoxy-1,2,3,4-tetrahydro-1-benzazepin-5-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:187601-84-9 SDS

187601-84-9Downstream Products

187601-84-9Relevant articles and documents

HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF

-

, (2019/07/13)

The present application is directed to compounds of Formula (I): compounds of Formula (II): compounds of Formula (III): and compounds of Formula (IV): compositions comprising these compounds and their uses, for example as medicaments and /or diagnostics.

Azabenzocycloheptenones. Part 20. Synthesis and utilisation of 4-amino-1,2,3,4-tetrahydro-1(1H)-benzazepines

Booker-Milburn, Kevin I.,Dunkin, Ian R.,Kelly, Frances C.,Khalaf, Abedawn I.,Learmonth, David A.,Proctor, George R.,Scopes, David I. C.

, p. 3261 - 3273 (2007/10/03)

1,2,3,4-Tetrahydro-6- and -7-methoxy-4-oxo-1-(p-tolylsulfonyl)quinolines 3 (R = tosyl, X = 6- and 7-OMe) and 1-ethoxycarbonylmethyl-1,2,3,4-tetrahydro-7-methoxy-4-oxoquinoline3 (R = CH2CO2Et, X = 7-OMe) have been ring-expanded in two

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