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(2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid benzyl ester is a synthetic compound derived from the reaction of (2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid with benzyl alcohol. It belongs to the family of aminocarbonyl compounds, which are known for their diverse biological activities. The benzyl ester group on the molecule enhances its stability and reduces reactivity, making it easier to handle and store. This chemical holds promising potential for use in pharmaceutical research and development.

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  • 18807-67-5 Structure
  • Basic information

    1. Product Name: (2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid benzyl ester
    2. Synonyms: (2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid benzyl ester;N,N-DI-CBZ-ETHYLENEDIAMINE
    3. CAS NO:18807-67-5
    4. Molecular Formula: C18H20N2O4
    5. Molecular Weight: 328.3624
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 18807-67-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid benzyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid benzyl ester(18807-67-5)
    11. EPA Substance Registry System: (2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid benzyl ester(18807-67-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 18807-67-5(Hazardous Substances Data)

18807-67-5 Usage

Uses

Used in Organic Synthesis:
(2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid benzyl ester is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions and contribute to the formation of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid benzyl ester is utilized for its potential applications in the development of new pharmaceuticals. Its unique structure and properties make it a valuable component in the synthesis of bioactive compounds with therapeutic potential.
Used in Pharmaceutical Research and Development:
(2-BenzyloxycarbonylaMino-ethyl)-carbaMic acid benzyl ester is employed in pharmaceutical research and development as a key intermediate in the synthesis of drug candidates. Its stability and reactivity make it suitable for use in the creation of novel therapeutic agents with diverse biological activities.

Check Digit Verification of cas no

The CAS Registry Mumber 18807-67-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,8,0 and 7 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 18807-67:
(7*1)+(6*8)+(5*8)+(4*0)+(3*7)+(2*6)+(1*7)=135
135 % 10 = 5
So 18807-67-5 is a valid CAS Registry Number.

18807-67-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2-Ethanediylbis(phenylmethyl carbamate)

1.2 Other means of identification

Product number -
Other names (2-BENZYLOXYCARBONYLAMINO-ETHYL)-CARBAMIC ACID BENZYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18807-67-5 SDS

18807-67-5Relevant articles and documents

Dynamic kinetic asymmetrie allylation of hydrazines and hydroxylamines

Mangion, Ian,Strotman, Neil,Drahl, Michael,Imbriglio, Jason,Guidry, Erin

supporting information; experimental part, p. 3258 - 3260 (2009/12/01)

Hydrazines and hydroxylamines have been found to be excellent nucleophiles for the palladium-catalyzed dynamic asymmetric allylic amination of vinyl epoxide, with good yields and enantioselectivities of up to 97% ee. This method is applicable to acyclic a

Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages

Dubowchik, Gene M,Radia, Shilpa,Mastalerz, Harold,Walker, Michael A.,Firestone, Raymond A.,Dalton King, H.,Hofstead, Sandra J.,Willner, David,Lasch, Shirley J.,Trail, Pamela A.

, p. 1529 - 1532 (2007/10/03)

Bivalent doxorubicin (DOX)-dipeptides (16a-c) were prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates. Conjugate 18b demonstrated antigen-s

Carbon Dioxide as a Phosgene Replacement: Synthesis and Mechanistic Studies of Urethanes from Amines, CO2, and Alkyl Chlorides

McGhee, William,Riley, Dennis,Christ, Kevin,Pan, Yi,Parnas, Barry

, p. 2820 - 2830 (2007/10/02)

Several carbamate esters were synthesized from amines, carbon dioxide, and alkyl chlorides.The effect of added base on the yield and selectivity of carbamate ester formation was found to be highly important with the use of sterically hindered guanidine bases giving the best results.Relative rate studies were carried out giving the following order of reactivity between carbamate anions in acetonitrile with benzyl chloride giving carbamate esters: Et2NCO2(-) = Bu2NCO2(-) > t-BuNHCO2(-) = CyNHCO2(-) = s-BuNHCO2(-) > PhNHCO2(-) > CyCH2NHCO2(-) = n-octylNHCO2(-) = n-BuNHCO2(-).Rate studies were carried out with the diethyl, s-butyl, phenyl, and n-butyl carbamates and activation parameters were determined to be Et2NCO2(-), ΔH(excit.) = 11.8 kcal/mol, ΔS(excit.) = -33 eu; s-BuNHCO2(-), ΔH(excit.) = 12.8 kcal/mol, ΔS(excit.) = -33 eu; PhNHCO2(-), ΔH(excit.) = 14.3 kcal/mol, ΔS(excit.) = -28 eu; n-BuNHCO2(-), ΔH(excit.) = 23.4 kcal/mol, ΔS(excit.) = -3 eu.The unusual results obtained from the use of n-BuNHCO2(-) prompted further studies which showed that the rate of the reaction was inversely dependent on carbon dioxide pressure (20 psig CO2, k = 4.84E-4 M-1 s-1; 120 psig CO2, k = 1.83E-4 M-1 s-1).Nitrogen NMR spectroscopy indicated, via a labeling study with 15N amines and 13C enriched carbon dioxide, the formation of doubly inserted product from the addition of two carbon dioxides to ethylamine in acetonitrile.

NOVEL UNSYMMETRICAL N,N-BIS(METHYLENE)BIPHOSPHONIC ACIDS OF α,ω-DIAMINES. PREPARATION AND CHARACTERIZATION OF BIS(METHYLENE)>-BIPHOSPHONIC ACID AND BIS(METHYLENE)>-BIPHOSPHONIC ACID

Redmore, Derek,Dhawan, Balram

, p. 233 - 238 (2007/10/02)

Reaction of ethylenediamine with phosphorous acid and formaldehyde in molar ratio 1:2:2 gives bis(methylene)>biphosphonic acid (2a) as the major product.Similarly, reaction of hexamethylenediamine with phosphorous acid and formaldehyde in molar ratio 1:2:2 yields bis(methylene)>biphosphonic acid (2b) which is isolated either as bis(methylene>biphosphonic acid (3b) or as bis(methylene)>biphosphonic acid (4b).Removal of the carbobenzoxy group with HBr 3b or the benzoyl group with HCl from 4b gives pure bis(methylene)>biphosphonic acid (2b).All compounds were characterized by 13C NMR, 31P NMR and elemental analysis.

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